In-vitro characterization of antibacterial bioactive glass containing ceria

Goh, Yi Fan; Alshemary, Ammar Z.; Akram, Mahreen; Kadir, Mohammed Rafiq Abdul; Hussain, Rafaqat

doi:10.1016/j.ceramint.2013.06.062

Cited by 102 publications

(87 citation statements)

References 39 publications

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“…silver, cerium ions) or alkaline ions leading to local pH rise. [56][57][58] ZnO QDs are effective antibacterial agents, and their antibacterial activity is considered to be from the production of H 2 O 2 from ZnO QDs, the release of Zn ions, or the generation of reactive oxygen species (ROS). 59 The reported minimum inhibition concentration (MIC) of Zn ions against S. aureus was lower than 9 mg mL…”

Section: Discussionmentioning

confidence: 99%

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

et al. 2016

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a Zinc (Zn)-containing materials have osteogenic and antibacterial activities while bioactive glass nanoparticles (BGN) show bone-bonding ability, as well as osteoconductive and osteoinductive properties. Zn-containing BGN are therefore considered to be promising materials for various biomedical applications, particularly in bone regeneration. In this study, we report a convenient method to prepare Zn-containing BGN by coating ZnO quantum dots (QDs) on BGN via electrostatic interactions. The synthesized ZnO-BGN nanocomposite particles are spherical and highly dispersed, and exhibit a unique fluorescence behavior under UV excitation, emitting three wavelengths in the violet, blue and green range.ZnO-BGN showed apatite-forming ability upon immersion in simulated body fluid, but their apatite formation was delayed compared to BGN. Interestingly, ZnO-BGN showed a rapid release of Zn ions at pH 4 but a far slower release at pH 7.4. ZnO-BGN also exhibited antibacterial effects on both Gram-positive and Gram-negative bacteria at the concentrations of 1, 0.1, and 0.01 mg mL , but ZnO-BGN inhibited the relative proliferation of hMSC compared to BGN and the control according to the MTT assay. Notably ZnO-BGN improved the osteogenic differentiation of hMSC as indicated by the determination of the alkaline phosphatase activity. In conclusion, coating quantum dots on BGN is a promising strategy to produce Zn-containing BGN. The synthesized ZnO-BGN are potential materials for bone regeneration, considering their apatite-forming ability, unique ion-release behavior, effective antibacterial activity, non-cytotoxicity, and osteogenic potential.

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Section: Discussionmentioning

confidence: 99%

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

et al. 2016

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“…The antibacterial effect revealed by BG has been attributed to the ion release capability in increasing the pH of the surrounding medium that can affect planktonic bacteria growth . Most of the studies report that the BG antibacterial effect against specific planktonic bacteria do not reflect realistic conditions of biofilm growth and pathogenicity at infected areas . Biofilm is a well‐organized microbial community embedded in an extracellular polymeric matrix composed of polysaccharides, nucleic acids, proteins and water, that adheres to different surfaces such as teeth, rehabilitation synthetic materials, bone, and soft tissues .…”

Section: Introductionmentioning

confidence: 99%

“…In an attempt in improving BG antibacterial and anti‐biofilm activity, several studies have reported positive antibacterial properties achieved by BG embedded with inorganic compounds containing silver, cerium, selenium, magnesium, zinc, or fluoride . Bromine, a chemical element corresponding to the halogen group, has been poorly explored in tissue engineering applications.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of multi‐species oral biofilm by bromide doped bioactive glass

Galárraga-Vinueza

Passoni

et al. 2017

J Biomedical Materials Res

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Bioactive glass is an attractive biomaterial that has shown excellent osteogenic and angiogenic effects for oral bone repairing procedures. However, anti-biofilm potential related to such biomaterial has not been completely validated, mainly against multi-species biofilms involved in early tissue infections. The aim of the present study was to evaluate the anti-biofilm effect of 58 S bioactive glass embedding calcium bromide compounds at different concentrations. Bioactive glass free or containing 5, or 10 wt % CaBr was synthesized by alkali sol-gel method and then characterized by physco-chemical analyses and scanning electron microscopy (SEM). Then, samples were tested by microbiological assays using optical density, real time q-PCR, and SEM. Bioactive glass particles showed accurate chemical composition and an angular shape with a bimodal size distribution ranging from 0.6 to 110 µm. The mean particle size was around 29 µm. Anti-biofilm effect was recorded for 5 wt % CaBr -doped bioactive glass against S. mitis, V. parvula, P. gingivais, S. gordoni, A. viscosus, F, nucleatum, P. gingivais. F. nucleatum, and P. gingivalis. Such species are involved in the biofilm structure related to infections on hard and soft tissues in the oral cavity. The incorporation of calcium bromide into bioactive glass can be a strategy to enhance the anti-biofilm potential of bioactive glasses for bone healing and infection treatment. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1994-2003, 2017.

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“…BGs have been modified over the years with the incorporation of diverse antibacterial and antibiofilm agents to counteract bone infection. Various studies have reported the incorporation of metal oxides, antibiotics and other organic agents into BGs; however, there is no consensus until present day concerning which antibiofilm agent is the most effective for bone infection treatment . Indeed BG of “S53P4” composition is commercially available as an effective agent to counteract osteomyelitis conditions .…”

Section: Discussionmentioning

confidence: 99%

Mesoporous bioactive glass embedding propolis and cranberry antibiofilm compounds

Galárraga-Vinueza

Mesquita‐Guimarães

Magini

et al. 2018

J Biomedical Materials Res

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The aim of this study was to evaluate the chemical reactivity of 58S mesoporous bioactive glass (MBG) particles in as-synthesized condition and after embedding propolis and cranberry antibiofilm compounds at different concentrations. MBG 58S was synthesized by alkali sol-gel method with the addition of the triblock pluronic copolymer P123 as surfactant. Samples were characterized by physicochemical properties measurement, N adsorption/desorption analysis, and field emission gun scanning electron microscopy (FEGSEM) observations. MBG powders were immersed into 5 and 10 µg/mL propolis or cranberry solutions for 24 h. The chemical reactivity of the specimens was evaluated by FEGSEM, EDX, FTIR, Ca/P ratio, XRD, and sample weight gain analysis after being immersed in simulated body fluid (SBF) for 8, 24, and 72 h. MBG particles exhibited the expected chemical composition with a particle size distribution ranging from 1.44 to 955 µm, and a mean particle size of 154 µm. MBG particles exhibited a pore volume of 0.8 cc/g, pore radius of ∼2 nm, and surface area of 350.2 m /g, according to BJH and BET analyses. A hydroxyl-carbonate apatite (HCAp) layer was formed on all samples after SBF immersion for 72 h. Pure MBG showed the highest chemical reactivity after 72 h, with the resulting apatite layer exhibiting a Ca/P ratio of ∼1.6 in accordance to stoichiometric biological apatite. MBG embedding propolis and cranberry can be considered for future microbiological analysis since the presence of propolis or cranberry did not interfere with MBG's ability to develop a HCAp layer, which is an essential feature for bone regeneration applications. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1614-1625, 2018.

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In-vitro characterization of antibacterial bioactive glass containing ceria

Cited by 102 publications

References 39 publications

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

Inhibition of multi‐species oral biofilm by bromide doped bioactive glass

Mesoporous bioactive glass embedding propolis and cranberry antibiofilm compounds

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