In vitro cariostatic effects of various iron supplements on the initiation of dental caries

Al-Shalan, Thakib A.

doi:10.1016/j.sdentj.2009.05.001

Cited by 13 publications

(11 citation statements)

References 29 publications

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“…In the present study, the iron concentration representing the entire iron element in saliva was detected, including iron(II) and iron(III). Iron(III) complex addition has been reported to have no cariostatic effect ( 43 ). Therefore, different valences of iron should be considered in the future.…”

Section: Discussionmentioning

confidence: 99%

Influences of pH and Iron Concentration on the Salivary Microbiome in Individual Humans with and without Caries

Zhou

Jiang

Wang

et al. 2017

Appl Environ Microbiol

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This study aimed to identify the differences in the oral microbial communities in saliva from patients with and without caries by performing sequencing with the Illumina MiSeq platform, as well as to further assess their relationships with environmental factors (salivary pH and iron concentration). Forty-three volunteers were selected, including 21 subjects with and 22 without caries, from one village in Gansu, China. Based on 966,255 trimmed sequences and clustering at the 97% similarity level, 1,303 species-level operational taxonomic units were generated. The sequencing data for the two groups revealed that (i) particular distribution patterns (synergistic effects or competition) existed in the subjects with and without caries at both the genus and species levels and (ii) both the salivary pH and iron concentration had significant influences on the microbial community structure.IMPORTANCE The significant influences of the oral environment observed in this study increase the current understanding of the salivary microbiome in caries. These results will be useful for expanding research directions and for improving disease diagnosis, prognosis, and therapy.

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Section: Discussionmentioning

confidence: 99%

Influences of pH and Iron Concentration on the Salivary Microbiome in Individual Humans with and without Caries

Zhou

Jiang

Wang

et al. 2017

Appl Environ Microbiol

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“…Many studies have shown the benefits of FS on tooth enamel 5,6,9 . A previous work subjected bovine enamel blocks to cariogenic challenges and to FS (15 mmol/L -1 ) and they reported a significant reduction in mineral loss of enamel and a change in phosphate concentration at the biofilm 9 , whereas another work evaluated the cariostatic effect of iron supplements at different concentrations (100% and 50%) on extracted human permanent teeth and observed a reduction in enamel demineralization after their use 6 . Moreover, other authors suggest that FS at 18 µg/mL compared with different concentrations (0.33, 0.840, and 70.0 µg Fe/mL) had better results in reducing enamel demineralization in bovine enamel 5 .…”

Section: Authors Contributionmentioning

confidence: 99%

“…FS has been analyzed in several studies in dentistry [5][6][7][8][9][10][11][12][13] using artificial dental models (mainly bovine teeth and human permanent teeth). The most frequently reported properties include reduction in the degree of enamel dissolution 5,8,13 , reduction of dental erosion 7,12 , alterations in biofilm composition (in situ) 9,10,14 , and oxidative modifications in glucosyltransferase promotion 11 .…”

Section: Introductionmentioning

confidence: 99%

“…The most frequently reported properties include reduction in the degree of enamel dissolution 5,8,13 , reduction of dental erosion 7,12 , alterations in biofilm composition (in situ) 9,10,14 , and oxidative modifications in glucosyltransferase promotion 11 . Another study focused on the cariostatic effect of FS prescribed in vitamin supplements containing iron 6 .…”

Section: Introductionmentioning

confidence: 99%

“…Due to social disparity, there is a high frequency of IDA in Brazilian children 2,3 , and pediatricians commonly prescribe FS supplementation 6,18 . The present study aimed to evaluate the effect of FS on demineralized and non-demineralized human deciduous teeth.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Effect of Ferrous Sulfate on Enamel Demineralization of Human Deciduous Teeth: An in Vitro Study

Gauw¹,

Costa²,

Silva³

et al. 2017

J Dent Pub H

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Objective: This study aimed to evaluate the effect of ferrous sulfate (FS) on demineralized and non-demineralized human deciduous teeth. Additionally, it was evaluated the penetration extent of FS and its remineralizing effect on the enamel of deciduous teeth using Polarized Light Microscopy (PLM). Method: The sample comprised 44 human deciduous teeth. The 44 crowns were divided randomly into four groups: group A (FS after demineralization), group B (FS without demineralization), group C (only demineralization), and group D (control group). FS at 0.45 mol/L-1 was used daily (15 days) and demineralization was done by pH cycling (7 days). Then, three longitudinal slices of the crowns were photographed using PLM. The degree of penetration of the lesion or stain was measured in micrometers, as well as the distance between the external enamel surface and the core of lesion. Results: Group A showed a dark stain on the outer surface of enamel larger than the group B. It is suggested, a remineralizing effect when comparing groups, A and C. The mean depth and standard deviation for groups A, B, and C were 4.27µm (±1.49), 3.72 µm (±1.68) and 5.00 µm (±1.84), respectively. No dark stains were observed in group D. Conclusion: FS stained the demineralized and non-demineralized human deciduous teeth. However, dark stains in the non-demineralized teeth were smaller or absent, than in the demineralized teeth. Therefore, FS may have a protective effect against demineralization.

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Caries prevalence and manganese and iron levels of drinking water in school children living in a rural/semi-urban region of North-Eastern Greece

Tsanidou

Nena

Rossos

et al. 2015

Environ Health Prev Med

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Objective The aim of this study was to correlate different combinations of manganese (Mn) and iron (Fe) concentration in drinking water with prevalence of dental caries in both primary and permanent dentition, among school children with similar socio-demographic characteristics. Methods Evros region, in North-Eastern Greece, was divided into four areas, according to combinations of levels of Mn and Fe in drinking water (High Mn-high Fe; High Mn-low Fe; Low Mn-high Fe; Low Mn-low Fe). Children of similar socio-economic background, attending either first or sixth grade (primary or permanent dentition, respectively) of elementary schools, were clinically assessed for caries by three dentists. Caries was defined by the use of dmft/DMFT index. A questionnaire answered by the parents was also analysed. Results 573 children were included. Caries prevalence was high in both age groups (64.2 % with mean dmft 3.3 ± 3.6 in primary and 60.7 % with mean DMFT 2.3 ± 2.5 in permanent dentition, respectively). Residence in a high Mn-low Fe area was associated with a significant OR for caries in both age groups [OR (95 % CIs) for primary and permanent dentition was, respectively, 3.75 (1.68-8.37), p = 0.001 and 3.09 (1.48-6.44), p = 0.003], independently of factors like sugar consumption or brushing frequency. Conclusion Prevalence of caries was high in general, and was associated with the combination of high Mn/low Fe levels in drinking water, independently of various sociodemographic factors.

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In vitro cariostatic effects of various iron supplements on the initiation of dental caries

Abstract: It was concluded that iron may have cariostatic effect on the in vitro development of dental caries in human teeth.

Cited by 13 publications

References 29 publications

Influences of pH and Iron Concentration on the Salivary Microbiome in Individual Humans with and without Caries

Influences of pH and Iron Concentration on the Salivary Microbiome in Individual Humans with and without Caries

Evaluation of the Effect of Ferrous Sulfate on Enamel Demineralization of Human Deciduous Teeth: An in Vitro Study

Caries prevalence and manganese and iron levels of drinking water in school children living in a rural/semi-urban region of North-Eastern Greece

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