In vitro capability of multi-walled carbon nanotubes modified with gonadotrophin releasing hormone on killing cancer cells

Yu, Bin; Yang, Jianshe; Li, Wenxin

doi:10.1016/j.carbon.2007.06.015

Cited by 39 publications

(16 citation statements)

References 25 publications

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“…[ 51 ] Non-differentiated Caco-2: EC 50 [l] = 602 ± 42 μ g/ml Differentiated Caco-2: EC 50 = 430 ± 29 μ g/ml [ 49 ] XTT[c] SWNT-PEG-based copolymer B16F10 1 day 20% cytotoxicity at 50 μ g/ml [ 18 ] Long MWNT Short MWNT A549 2 days 5-10% at 100 μ g/ml Non-dependent on MWNT length [ 28 ] LDH [d] MWNT Human mononuclear cells 4-24h No signifi cant cytotoxicity [ 33 ] Long MWNT Short MWNT A549 2 days 35-40% at 100 μ g/ml Non-dependent on MWNT length [ 28 ] SWNT-COOH Differentiated & Non-differentiated Caco-2 cells 1 day Non-differentiated Caco-2: EC 50 = 782 ± 77 μ g/ml Differentiated Caco-2: EC 50 = 713 ± 54 μ g/ml [ 49 ] …”

Section: Research Newsmentioning

confidence: 99%

Carbon Nanotubes in the Biological Interphase: The Relevance of Noncovalence

Lee

Geckeler

2010

Advanced Materials

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With the increasing interest in the biological applications of carbon nanotubes, their interactions in the biological interphase and their general cytotoxicity have become major issues. In spite of their salient properties, major hurdles still exist for their use in biological applications, due to their main characteristics, including their hydrophobic surfaces and tendency to aggregate, as well as their unknown interactions in the cellular interphase. In this Research News, these characteristics of carbon nanotubes, a model nanomaterial, are investigated. Thus, the cytotoxicity of carbon nanotubes, the influence of functionalization, as well as their interactions with different mammalian cell lines are studied. Moreover, suggestions for the improvement of their biocompatibility and the design of biocompatible carbon nanotube-based systems are provided.

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Section: Research Newsmentioning

confidence: 99%

Carbon Nanotubes in the Biological Interphase: The Relevance of Noncovalence

Lee

Geckeler

2010

Advanced Materials

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“…The gonadotropin (GnRH) functionalized carboxylic MWCNTs tended to kill HeLa cells after they were internalized by the GnRH receptor-positive cells [114]. Table 4 provides the summary of CNT-based DDS for the delivery of biomolecules.…”

Section: (2011) 4077-4097mentioning

confidence: 99%

Delivery of drugs and biomolecules using carbon nanotubes

Vashist

Zheng

Pastorin

et al. 2011

Carbon

248

127

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Carbon nanotubes (CNTs) have emerged as one of the most advanced nanovectors for the highly efficient delivery of drugs and biomolecules. They offer several appealing features such as large surface areas with well defined physico-chemical properties as well as unique optical and electrical properties. They can be conjugated non-covalently or covalently with drugs, biomolecules and nanoparticles. Albeit some pending concerns about their toxicity in vitro and in vivo, functionalized CNTs appear to exhibit very low toxicity and are not immunogenic. Thus, they could be promising carriers with a great potential for the development of a new-generation delivery system for drugs and biomolecules. There have been significant advances in the field of CNT-based drug delivery, especially in the specific targeting of anticancer and anti-inflammatory drugs for tissues and organs in the body, where their therapeutic effect is highly required. Other promising applications are the delivery of DNA, RNA and proteins.Crown

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“…Yu et al developed gonadotropin-releasing hormone (GnRH)-functionalized MWCNTs (MWCNTs-GnRH) to explore interactions in prostate cancer cells (DU 145 cells); they reported the dose-dependent toxicity of these conjugates [84]. In another study, Tripisciano et al designed and evaluated cisplatin (CDDP)-loaded SWCNTs in terms of their cytotoxicity in the prostate cancer cell lines, DU 145 and PC 3 [85].…”

Section: Prostate Cancermentioning

confidence: 98%