Validating the anticancer potential of carbon nanotube-based therapeutics through cell line testing

Kesharwani, Prashant; Mishra, Vijay; Jain, Narendra Kumar

doi:10.1016/j.drudis.2015.05.004

Cited by 55 publications

(13 citation statements)

References 92 publications

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“…Upon diagnosis, 80 % of pancreatic cancer cases are deemed inoperable due to the high risk of tumor infiltration with surrounding blood vessels and digestive ducts [3][4][5] . Due to the complex nature of malignant pancreatic cancers the incidence and death rates have been increasing although the overall cancer incidence and death rates are declining for other cancers 6 .…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells

et al. 2015

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Cancer stem-like cells (CSLCs) play a pivotal role in acquiring multidrug resistant (MDR) phenotypes. It has been established that pancreatic cancers overexpressing CD44 receptors (a target of hyaluronic acid; HA) is one of the major contributors for causing MDR. Therefore, targeted killing of CD44 expressing tumor cells using HA based active targeting strategies may be beneficial for eradicating MDR-pancreatic cancers. Here, we report the synthesis of a new HA conjugate of copoly(styrene maleic acid) (HA-SMA) that could be engineered to form nanomicelles with a potent anticancer agent, 3,4-difluorobenzylidene curcumin (CDF). The anticancer activity of CDF loaded nanomicelles against MiaPaCa-2 and AsPC-1 human pancreatic cancer cells revealed dose-dependent cell killing. Results of cellular internalization further confirmed better uptake of HA engineered nanomicelles in triple-marker positive (CD44+/CD133+/EpCAM+) pancreatic CSLCs compared with triple-marker negative (CD44-/CD133-/EpCAM-) counterparts. More importantly, HA-SMA-CDF exhibited superior anticancer response toward CD44+ pancreatic CSLCs. Results further confirmed that triple-marker positive cells treated with HA-SMA-CDF caused significant reduction in CD44 expression and marked inhibition of NF-κB that in-turn can mitigate their proliferative and invasive behavior. Conclusively, these results suggest that the newly developed CD44 targeted nanomicelles may have great implications in treating pancreatic cancers including the more aggressive pancreatic CSLCs.

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Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells

et al. 2015

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“…Whilst these early studies show promise, CNTs accumulate in the liver, are non-biodegradable, and show poor solubility with a tendency to aggregate. These challenges of toxicity limit the current clinical translation of CNTs, and are being addressed [133].…”

Section: Cancer Hyperthermiamentioning

confidence: 99%

Antibody-Targeted Nanoparticles for Cancer Treatment

2016

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Nanoparticles are diverse and versatile with physical properties that can be employed for use in cancer medicine. Targeting nanoparticles using antibodies and antibody fragments could overcome some of the limitations seen with current targeted therapies. This review will discuss the role of antibody-targeted nanoparticles in the treatment of cancer: as delivery vehicles, targeted theranostic agents and in the evolving field of cancer hyperthermia.

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“…CNTs can be surface-modified through covalent or noncovalent approaches, which broadens the choices of surface modification using small chemicals [284] , mesoporous silica [285] , DNA aptamers [286] or proteins [287] . CNTs can serve as therapeutic agents for anti-cancer treatment directly [288] or can encapsulate or adsorb therapeutic materials such as drugs, genes and proteins [289] .…”

Section: Theranostic Nanomaterialsmentioning

confidence: 99%

Advanced Functional Nanomaterials for Theranostics

Huang

Lovell

2016

Adv Funct Materials

205

135

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Nanoscale materials have been explored extensively as agents for therapeutic and diagnostic (i.e. theranostic) applications. Research efforts have shifted from exploring new materials in vitro to designing materials that function in more relevant animal disease models, thereby increasing potential for clinical translation. Current interests include non-invasive imaging of diseases, biomarkers and targeted delivery of therapeutic drugs. Here, we discuss some general design considerations of advanced theranostic materials and challenges of their use, from both diagnostic and therapeutic perspectives. Common classes of nanoscale biomaterials, including magnetic nanoparticles, quantum dots, upconversion nanoparticles, mesoporous silica nanoparticles, carbon-based nanoparticles and organic dye-based nanoparticles, have demonstrated potential for both diagnosis and therapy. Variations such as size control and surface modifications can modulate biocompatibility and interactions with target tissues. The needs for improved disease detection and enhanced chemotherapeutic treatments, together with realistic considerations for clinically translatable nanomaterials will be key driving factors for theranostic agent research in the near future.

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Validating the anticancer potential of carbon nanotube-based therapeutics through cell line testing

Cited by 55 publications

References 92 publications

Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells

Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells

Antibody-Targeted Nanoparticles for Cancer Treatment

Advanced Functional Nanomaterials for Theranostics

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