In-vitro biotransformation of tea using tannase produced by Enterobacter cloacae 41

Govindarajan, Rasiravathanahalli Kaveriyappan; Khanongnuch, Chartchai; Mathivanan, Krishnamurthy; Shyu, Douglas J. H.; Sharma, Kanti Prakash; Mandal, Surajit De

doi:10.1007/s13197-021-05018-3

Cited by 11 publications

(10 citation statements)

References 34 publications

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“…Numerous chemicals are produced in hemp through secondary metabolism. They include cannabinoids, terpenes, and phenolic compounds [ 19 ]; these will be further described in the next sections. Although the pharmacological properties of cannabinoids have been extensively studied and are the most recognized hemp bioactives, other components have also been associated with potent health-promoting properties [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…They include cannabinoids, terpenes, and phenolic compounds [ 19 ]; these will be further described in the next sections. Although the pharmacological properties of cannabinoids have been extensively studied and are the most recognized hemp bioactives, other components have also been associated with potent health-promoting properties [ 19 ]. At the same time, these products are free of chemicals and toxins that are used in most synthetic cosmetics.…”

Section: Introductionmentioning

confidence: 99%

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Biosynthesis of Phytocannabinoids and Structural Insights: A Review

et al. 2023

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Cannabis belongs to the family Cannabaceae, and phytocannabinoids are produced by the Cannabis sativa L. plant. A long-standing debate regarding the plant is whether it contains one or more species. Phytocannabinoids are bioactive natural products found in flowers, seeds, and fruits. They can be beneficial for treating human diseases (such as multiple sclerosis, neurodegenerative diseases, epilepsy, and pain), the cellular metabolic process, and regulating biological function systems. In addition, several phytocannabinoids are used in various therapeutic and pharmaceutical applications. This study provides an overview of the different sources of phytocannabinoids; further, the biosynthesis of bioactive compounds involving various pathways is elucidated. The structural classification of phytocannabinoids is based on their decorated resorcinol core and the bioactivities of naturally occurring cannabinoids. Furthermore, phytocannabinoids have been studied in terms of their role in animal models and antimicrobial activity against bacteria and fungi; further, they show potential for therapeutic applications and are used in treating various human diseases. Overall, this review can help deepen the current understanding of the role of biotechnological approaches and the importance of phytocannabinoids in different industrial applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biosynthesis of Phytocannabinoids and Structural Insights: A Review

et al. 2023

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“…Tannase basically hydrolyze ester and depside linkages to produce gallic acid and other products 9 . The enzyme is produced by a variety of fungal and bacterial species 10 …”

Section: Introductionmentioning

confidence: 99%

Reconnoitring the antioxidant and antibacterial potential of different fruits after tannin acyl hydrolase mediated biotransformation

Rippin¹,

Sharma²,

Beniwal

2023

Biotech and App Biochem

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Condensed and hydrolyzable tannins are secondary metabolites present in almost every plant part. Tannase enzyme acts on hydrolyzable tannins to produce gallic acid and tannase‐mediated end‐products with immense therapeutic potential. Seven different fruits with significant presence of hydrolyzable tannin content were selected to check for phenol, tannin, and hydrolyzable tannin contents. Prunus domestica had the maximum phenol content, that is, 85.4 ± 0.207, followed by Syzygium cumini, Fragaria ananassa, Rubus fruticosus, and Psidium guajava. Plum showed the maximum number of hydrolyzable tannins. Fruit extracts were subjected to tannase hydrolysis and their antimicrobial and antioxidant activities were determined. There was a significant increase in the antioxidant abilities of the fruits with Punica granatum extract, displaying the highest decline of 132 units of IC50 followed by F. ananassa hydrolyzable extract, showing a decrease from 224.75 to 119.98 μg/mL. The extracts also depicted a significant increase in antibacterial activity after hydrolysis against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus with Rubus idaeus aqueous extract observed to be most effective against E. coli. The increase in antioxidant and antibacterial activity can be attributed to the production of tannase‐mediated products formed after the biotransformation of hydrolyzable tannins present in the aqueous extracts.

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“…Gallic acid has extended its utilization as a valuable antibacterial chemical, antitumor drug, antioxidant agent, food preservative, and analgesic reliever. − In addition, gallic acid is used as an important constituent in photography and printing inks. Furthermore, tannase has been introduced for use in environmental fields, for instance, the treatment of polyphenols in tannery effluents. , The abilities of gallic acid production and tannin removal make tannase useful for various commercial applications in food, beverage, tannery, pharmaceutical, animal feed, and chemical industries. − …”

Section: Introductionmentioning

confidence: 99%

Construction of a Tannase-Immobilized Magnetic Graphene Oxide/Polymer Nanobiocatalyst with Enhanced Enzyme Stability for High-Efficiency Transformation of Tannins

Huan

Liu

et al. 2022

ACS Sustainable Chem. Eng.

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Highly efficient biotransformation of natural compounds into sustainable biochemical products has attracted great attention. The integration of nanoscience and biotechnology provides attractive solutions for this purpose. Herein, we report the fabrication of a nanobiocatalyst employing a magnetic graphene oxide/polymer nanocomposite as a robust carrier for immobilizing the tannase enzyme, which catalyzes the bioconversion of tannin into gallic acid and glucose. Attributed to the covalent immobilization and propitious interface properties of the coated polymers comprising polyethylenimine and sodium hyaluronate, the nanobiocatalyst is stable without compromising the enzymatic activity. The nanobiocatalyst exhibits 91.8% activity of original tannase and a high enzyme bound amount of 356.8 mg g −1 . The stability tests at variable temperatures (30−80 °C) and under pH conditions (4.0−9.0), various inhibitors, and a long-term storage process (25 days) reveal that the heterofunctional support and surface microenvironment facilitate better stability, adaptability, and tolerance ability of the nanobiocatalyst modified with a multicomponent polymer in comparison to the free enzyme and the nanobiocatalyst modified with the monocomponent polyethylenimine. The nanobiocatalyst maintains 94.2% of its initial activity after 10 consecutive uses and is 100% recoverable by applying an external magnet. Moreover, the nanobiocatalyst is used to hydrolyze 96.5 and 95.1% tannins in extracts from Chinese Torreya grandis testa and cake, respectively. These results establish the practicability of magnetic graphene oxide-based supports for immobilizing tannase and the promising application of immobilized tannase for efficient tannin hydrolysis.

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In-vitro biotransformation of tea using tannase produced by Enterobacter cloacae 41

Cited by 11 publications

References 34 publications

Biosynthesis of Phytocannabinoids and Structural Insights: A Review

Biosynthesis of Phytocannabinoids and Structural Insights: A Review

Reconnoitring the antioxidant and antibacterial potential of different fruits after tannin acyl hydrolase mediated biotransformation

Construction of a Tannase-Immobilized Magnetic Graphene Oxide/Polymer Nanobiocatalyst with Enhanced Enzyme Stability for High-Efficiency Transformation of Tannins

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