In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites

Andriani, Yosephine; Morrow, Isabel C.; Taran, Elena; Edwards, Grant; Schiller, Tara L.; Osman, Azlin Fazlina; Martin, Darren J.

doi:10.1016/j.actbio.2013.05.021

Cited by 38 publications

(36 citation statements)

References 37 publications

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“…Short chain siloxane end-unit entities (e.g. 1,1,3,3,3-pentamethyldisiloxane, PMDS) possess antislipping effects relative to ␤CD macrocycle and enhance inclusion complex biostability by decreasing its decomposition rate in the body [2,13].…”

Section: Introductionmentioning

confidence: 99%

TGA/DTA–FTIR–MS coupling as analytical tool for confirming inclusion complexes occurrence in supramolecular host–guest architectures

Varganici¹,

Marangoci²,

Roşu³

et al. 2015

Journal of Analytical and Applied Pyrolysis

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Section: Introductionmentioning

confidence: 99%

TGA/DTA–FTIR–MS coupling as analytical tool for confirming inclusion complexes occurrence in supramolecular host–guest architectures

Varganici¹,

Marangoci²,

Roşu³

et al. 2015

Journal of Analytical and Applied Pyrolysis

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“…Current PDMS‐based TPUs available for clinical applications are: Elast‐Eon™ (based on PDMS/PHMO macrodiol) from AorTech Biomaterials Pty which is used in cardiovascular applications (vascular grafts, blood pumps, artificial heart, cardiac pacemakers, stent, etc. ), catheters, orthopedic implants; Angioflex ® [based on PDMS/poly(tetramethylene oxide) macrodiol] from Applied Biomedical Corp., which is used for heart valves, artificial heart blood pumping diaphragms and Cardiothane ® −51 [based on PDMS/poly(tetramethylene oxide) macrodiol] from Arrow International, used for artificial hearts, intra‐aortic balloons and blood conduits . Furthermore, PurSil™ and PurSil‐AL™ (aromatic and aliphatic siloxane polyether TPUs) from Polymer Technology Group are used in long‐ and short‐term biomedical applications, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…The requirements of these materials for the manufacture of various medical devices for long and short‐term use depend on the intended duration of use, intended method of application and function . Generally, their usage in blood‐contacting applications is limited due to their long‐term biodegradability, thrombus formation, mechanical functions or some limitation of an endothelial lining in human grafts . The introduction of PDMS into the polymer chain has the advantage of imparting some of the attractive properties of PDMS to TPUs, such as high flexibility, excellent thermal, oxidative and hydrolytic stability and low surface energy .…”

Section: Introductionmentioning

confidence: 99%

Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft segment contents, noncytotoxic chemistry, and nonadherent properties toward endothelial cells

Stefanović

Djonlagić

Tovilović

et al. 2014

J. Biomed. Mater. Res.

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Polyurethane copolymers based on α,ω-dihydroxypropyl poly(dimethylsiloxane) (PDMS) with a range of soft segment contents were prepared by two-stage polymerization, and their microstructures, thermal, thermomechanical, and surface properties, as well as in vitro hemo- and cytocompatibility were evaluated. All utilized characterization methods confirmed the existence of moderately microphase separated structures with the appearance of some microphase mixing between segments as the PDMS (i.e., soft segment) content increased. Copolymers showed higher crystallinity, storage moduli, surface roughness, and surface free energy, but less hydrophobicity with decreasing PDMS content. Biocompatibility of copolymers was evaluated using an endothelial EA.hy926 cell line by direct contact, an extraction method and after pretreatment of copolymers with multicomponent protein mixture, as well as by a competitive protein adsorption assay. Copolymers showed no toxic effect to endothelial cells and all copolymers, except that with the lowest PDMS content, exhibited resistance to endothelial cell adhesion, suggesting their unsuitability for long-term biomedical devices which particularly require re-endothelialization. All copolymers exhibited excellent resistance to fibrinogen adsorption and adsorbed more albumin than fibrinogen in the competitive adsorption assay, suggesting their good hemocompatibility. The noncytotoxic chemistry of these synthesized materials, combined with their nonadherent properties which are inhospitable to cell attachment and growth, underlie the need for further investigations to clarify their potential for use in short-term biomedical devices.

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“…Andriani et.al studied the in vitro biostability of polyurethane containing organically modified clay (organoclay) with different types of surface modification. They found that the nanocomposite incorporating the most hydrophobic organoclay resulted in greater biostability by hindering greater extent of matrix surface re-structuring upon oxidative exposure [7]. These findings show that the barrier properties of the polymers may be impacted by the organoclay, thus can be controlled to enhance the biostability.…”

Section: Introductionmentioning

confidence: 84%

Thermal properties of ethyl vinyl acetate (EVA)/montmorillonite (MMT) nanocomposites for biomedical applications

et al. 2016

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Abstract. The viability of nanocomposites comprising Ethyl Vinyl Acetate (EVA) filled montmorillonite (MMT) nanoclay as candidate materials of biomedical devices was investigated. EVA/MMT nanocomposites were prepared by incorporating the ratios 0, 1, 3 and 5% of organoclay MMT to EVA copolymer. In vitro biostability of the neat EVA and EVA nanocomposites was compared and assessed by exposing the materials to oxidizing and hydrolytic agents for 4 weeks at 37°C. The thermal properties of the neat EVA and EVA nanocomposites nanoclay filled were studied by using thermogravimetric analysis (TGA). TGA results indicate that the EVA nanocomposite sample containing 1 wt% MMT exhibits higher T onset and significant reduction in the rate of mass loss as compared to the neat EVA and other nanocomposites.

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In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites

Cited by 38 publications

References 37 publications

TGA/DTA–FTIR–MS coupling as analytical tool for confirming inclusion complexes occurrence in supramolecular host–guest architectures

TGA/DTA–FTIR–MS coupling as analytical tool for confirming inclusion complexes occurrence in supramolecular host–guest architectures

Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft segment contents, noncytotoxic chemistry, and nonadherent properties toward endothelial cells

Thermal properties of ethyl vinyl acetate (EVA)/montmorillonite (MMT) nanocomposites for biomedical applications

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