In vitro biological activity comparison of some hydroxyapatite-based composite materials using simulated body fluid

Czikó, Melinda; Bogya, Erzsébet-Sára; Barabáş, Réka; Bizo, Liliana; Ştefan, R.

doi:10.2478/s11532-013-0293-5

Cited by 12 publications

(9 citation statements)

References 31 publications

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“…The FTIR spectra provided lines similar to each other, which can be attributed to hydroxyapatite. Hydroxyl stretch, with its typical bands located between 3500 and 3200 cm −1 [82,83], can be observed just for the coatings immersed in SBF. These peaks are visible for the surfaces immersed for 3 and 14 days with a lower intensity and are completely invisible for the samples immersed for 1, 7, and 21 days.…”

Section: Ftir After Immersion In Dmem Sbf and Pbsmentioning

confidence: 91%

In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids

et al. 2019

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Considering the requirements of medical implantable devices, it is pointed out that biomaterials should play a more sophisticated, longer-term role in the customization and optimization of the material–tissue interface in order to ensure the best long-term clinical outcomes. The aim of this contribution was to assess the performance of silicon carbide–hydroxyapatite in various simulated biological fluids (Dulbecco’s modified Eagle’s medium (DMEM), simulated body fluid (SBF), and phosphate buffer solution (PBS)) through immersion assays for 21 days at 37 ± 0.5 °C and to evaluate the electrochemical behavior. The coatings were prepared on Ti6Al4V alloy substrates by magnetron sputtering method using two cathodes made of hydroxyapatite and silicon carbide (SiC). After immersion assays the coating’s surface was analyzed in terms of morphology, chemical and phase composition, and chemical bonds. According to the electrochemical behavior in the media investigated at 37 ± 0.5 °C, SiC addition inhibits the dissolution of the hydroxyapatite in DMEM acellular media. Furthermore, after adding SiC, the slow degradation of hydroxyapatite in PBS and SBF media as well as biomineralization in DMEM were observed.

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Section: Ftir After Immersion In Dmem Sbf and Pbsmentioning

confidence: 91%

In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids

et al. 2019

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“…Kim et al and Czikó et al explained the mechanism of bonelike apatite formation on the surface of CP cement sets in SBF solution. 28,29 They explained that the heat-treated CPCs have a negative surface charge due to the existence of high content of hydroxyl and phosphate groups on the surface of the cement. Thus, these functional groups could interact with the positive calcium ions after soaking in SBF solutions and gain a positive surface charge.…”

Section: Variation Of Calcium and Phosphorus Ions Concentrationmentioning

confidence: 99%

In vitro apatite formation of calcium phosphate composite synthesized from fish bone

Asadollahzadeh

Rabiee

Salimi-Kenari

2019

Int J Applied Ceramic Tech

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Calcium phosphate‐based composite (CPC) is the main biomaterial substitute used for bone repair. Properties affecting bioactivity of this composite vary depending on the types of calcium phosphate crystalline phases. Hence, in this study, bioactivity behavior of novel CPC cement by the incorporation of calcium phosphate (CP), which was obtained from fish bones, dicalcium phosphate dehydrate, and chitosan solution, was monitored in simulated body fluid (SBF). In advance, the microstructure of CP produced by heat treatment (annealing) of fish bone was evaluated at two different temperatures 600 and 900°C. The X‐ray diffraction (XRD) results showed that there was no secondary phase formation aside from natural hydroxyapatite (HA) in bones annealed; and the annealing process enhanced the crystallinity of CP phase in the bone matrix particularly when annealed at 900°C. After incubation of CPC cement in SBF, bone bonding ability and producing of biomimetic HA coat on the CPC cement surface were confirmed using XRD, fourier‐transform infrared spectroscopy, and scanning electron microscopy. The analysis results show that needle‐like and cauliflower apatite layer with the crystallite size about 100 nm was grown on the surface of CPC cement after 28 days incubation in SBF. Regardless of above findings, we conclude that varying the annealing temperature has tremendous effect on the production of natural HA from fish bone with required properties and the ultimate morphology of obtained CPC cements after soaking is directly depended on the degree of crystallinity of the prepared natural HA.

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“…The preparation of SBF solution is described in [44], based on the receipt of Kokubo [45]. Before and after SBF immersion the composites were studied with SEM and XRD methods and during the experiments were monitored the variation of the weight and the concentration of calcium and phosphorous ions .…”

Section: In Vitro Characterizationmentioning

confidence: 99%

Preparation and characterization of carboxyl functionalized multiwall carbon nanotubes–hydroxyapatite composites

Barabáş

Katona

Bogya

et al. 2015

Ceramics International

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In vitro biological activity comparison of some hydroxyapatite-based composite materials using simulated body fluid

Cited by 12 publications

References 31 publications

In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids

In Vitro Activity Assays of Sputtered HAp Coatings with SiC Addition in Various Simulated Biological Fluids

In vitro apatite formation of calcium phosphate composite synthesized from fish bone

Preparation and characterization of carboxyl functionalized multiwall carbon nanotubes–hydroxyapatite composites

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