In vitro biological activities and preliminary phytochemical screening of different extracts from Achillea sintenisii Hub- Mor

Anlaş, Ceren; Bakırel, Tülay; Üstüner, Oya; Alkan, Fulya Üstün; Diren-Sigirci, Belgi; Çalışkan, Ufuk Koca; Karakus, Methiye Mancak-; Dogan, Üzeyir; Ak, Seyyal; Akpulat, H. Aşkın

doi:10.1016/j.arabjc.2022.104426

Cited by 3 publications

(2 citation statements)

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“…A. nobilis ethanol extracts were showed highest DPPH radical scavenging activity with the IC 50 value of 6 and 10 μg/mL, respectively than the other extracts [53] . In another study, A. sintenisii ethanol extract showed DPPH radical scavenging with the IC 50 value of 184.31 μg/mL [54] . In this study, A. sintenisii showed moderate DPPH radical scavenging activity (IC 50 : 98.53 μg/mL).…”

Section: Resultsmentioning

confidence: 43%

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Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor

Eruygur,

Buyukyildirim,

Tetik Rama

et al. 2023

Chemistry & Biodiversity

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Achillea (Asteraceae) species have been traditionally used for their different therapeutical properties. In this study, phytochemical composition of aerial parts of A. sintenisii which is endemic in Turkey was determined with Liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS). To evaluate the wound healing potential, the cream formulation prepared from A. sintenisii was tested on the linear incision wound model in mice. In vitro enzyme inhibitory activity tests were performed on elastase, hyaluronidase, and collagenase. In the histopathological examination, angiogenesis and granulation tissue formation were significantly increased in A. sintenisii treatment groups compared to the negative control group. As a result of this study, it is thought that the enzyme inhibition and antioxidant activity of the plant may contribute to the wound healing process. According to LC/MS/MS analysis result, quinic acid (24.261 μg/mg extract) and chlorogenic acid (14.97 μg/mg extract) were identified as main constituents of the extract.

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Section: Resultsmentioning

confidence: 43%

“…[53] In another study, A. sintenisii ethanol extract showed DPPH radical scavenging with the IC 50 value of 184.31 μg/mL. [54] In this study, A. sintenisii showed moderate DPPH radical scavenging activity (IC 50 : 98.53 μg/mL).…”

Section: Discussionmentioning

confidence: 48%