In vitro bioactivity of titanium-doped bioglass

Abstract

Previous studies have suggested that incorporating small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigates the in vitro bioactivity of a titanium doped bioglass and compares the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.

Bioactivity studies on TiO2-bearing Na2O–CaO–SiO2–B2O3 glasses

“…Hence maintaining a A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 4 balance between degradation rate and bone remolding time is crucial for biomedical applications. It is also well established that the degradation rate can be controlled by modifying the glass composition, with some metallic oxides in the glass network, such as TiO 2 [16][17][18][19][20][21][22]. TiO 2 has a tendency to adsorb water at the surface, resulting in the formation of TiOH groups.…”

Preparation and physical‐biological characterization on titanium doped fluorophosphate nanobioglass: Bone implants

“…The P, Ca, Na, and O spectra of the atoms of mineralization in new bone is present in the interface. The presence of fluoride ions increases the transformation rate considerably 37,38 …”

“…The presence of fluoride ions increases the transformation rate considerably. 37,38 As a result of osteogenesis, the histological section of the femoral condyle implant with calcein fluorescence explains the new bone formation in dark fluorescent green. The nonfluorescent calcein AM dye is hydrolyzed by cellular esterases to give calcein, which is fluorescent and is retained in the cytoplasm.…”

Characterization, in vitro bioactivity and biological studies of sol‐gel‐derived TiO2 substituted 58S bioactive glass

“…Moreover some researchers have reported that the addition of Ti reduced cell viability, or in some cases, it was not noted that the presence of 5% Ti is optimal. Still, others did not observe biocompatibility 54–56 . Additionally, Rajendran et al reported that 57 the addition of Ti above one mol.% reduced the HA forming ability.…”