In vitro bioactivity and antibacterial properties of bismuth oxide modified bioactive glasses

S, Sakthi Prasad; Ratha, Itishree; Adarsh, Tarun; Anand, Akrity; Sinha, Prasanta Kumar; Diwan, Prerna; Annapurna, K.; Biswas, Kaushik

doi:10.1557/jmr.2017.442

Cited by 28 publications

(3 citation statements)

References 35 publications

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“…The cell proliferation studies were carried out on polished bulk samples using MC3T3 (Mouse osteoblast) cells in triplicate adapting 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay protocol given elsewhere. , The S53P4 glass sample was synthesized as reported elsewhere and used as control. All of the samples, including the control, were seeded with 5000 cells.…”

Section: Methodsmentioning

confidence: 99%

Structure and Stability of High CaO- and P₂O₅-Containing Silicate and Borosilicate Bioactive Glasses

Prasad¹,

Gaddam

Jana³

et al. 2019

J. Phys. Chem. B

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The present work elucidates about the structure of bioactive glasses having chemical compositions expressed as (mol %) (50.0 – x)SiO2–xB2O3–9.3Na2O–37CaO–3.7P2O5, where x = 0.0, 12.5, 25, and 37.5, and establishes a correlation between the structure and thermal stability. The structural modifications in the parent boron-free glass (B0) with the gradual substitutions of B2O3 for SiO2 are assessed by Raman and 29Si, 31P, 11B, and 23Na magic angle spinning (MAS)-nuclear magnetic resonance (NMR) spectroscopies. The structural studies reveal the presence of QSi 2 and QSi 3 structural units in both silicate and borosilicate glasses. However, QSi 4(3B) units additionally form upon incorporating B2O3 in B0 glass. B-containing silicate glasses exhibit both three-coordinated boron (BIII) and four-coordinated boron (BIV) units. The 31P MAS-NMR studies reveal that the majority of phosphate species exist as isolated orthophosphate (QP 0) units. The incorporation of B2O3 in B0 glass increases the cross-linking between the SiO4 and BO4 structural units. However, incorporation of B2O3 lowers the glass thermal stability (ΔT), as shown by differential scanning calorimetry. Although both silicate and borosilicate glasses exhibit good in vitro apatite-forming ability and cell compatibility, the bactericidal action against Escherichia coli bacteria is more evident in borosilicate glass in comparison to silicate base glass. The controlled release of (BO3)3– ions from boron-modified bioactive glasses improves both the cell proliferation and the antibacterial properties, making them promising for hard tissue engineering applications.

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Section: Methodsmentioning

confidence: 99%

Structure and Stability of High CaO- and P₂O₅-Containing Silicate and Borosilicate Bioactive Glasses

Prasad¹,

Gaddam

Jana³

et al. 2019

J. Phys. Chem. B

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“…This study reported cell viability higher than 80% for different cell lines, namely, mouse fibroblasts (L929), MC3T3-E1, rat osteosarcoma-derived cells (UMR106), and human osteosarcoma cells (U2OS) [ 345 ]. Prasad et al [ 346 ] investigated in vitro cell proliferation of mouse fibroblast (NIH3T3) and antibacterial properties of Bi containing S53P4 BG against E. coli . After 11 days, the percentage of cell proliferation exposed to Bi containing S53P4 BG (1 and 2 wt.%) became higher compared to the non-doped S53P4 glass.…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

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“…From the antibacterial point of view, it has been shown that BGs can decrease the risk of infections caused by both Gram-positive and Gram-negative strains (Liu et al, 2016a,b; Ottomeyer et al, 2016). This decrease can be achieved through two mechanisms (usually combined) regulated by the dissolution of BGs, including (i) the local increase of pH values in the injured site (due to the delivery of alkaline cations such as Ca 2+ and Na + ) and (ii) the release of antibacterial ions (e.g., silver, copper, zinc, cerium, and gallium) (Ratha et al, 2018; Bauer et al, 2019; Wajda et al, 2019). However, it has been documented that the effect of pH depends on the species of bacteria involved.…”

Section: Evidence Of Bg Suitability For Treating Burnsmentioning

confidence: 99%

Using Bioactive Glasses in the Management of Burns

Kargozar

Mozafari

Hamzehlou

et al. 2019

Front. Bioeng. Biotechnol.

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The management of burn injuries is considered an unmet clinical need and, to date, no fully satisfactory solution exists to this problem. This mini-review aims to explore the potential of bioactive glasses (BGs) for burn care due to the therapeutic effects of their ionic dissolution products. BGs have been studied for more than 40 years and boast a long successful history in the substitution of damaged tissues, especially bone. Considering their exceptional versatility and attractive characteristics, these synthetic materials have also recently been proposed in the treatment of soft tissue-related disorders such as skin wounds. Specifically, improving fibroblast proliferation, inducing angiogenesis, and eliciting antibacterial activity (with the additional advantage of avoiding administration of antibiotics) are all considered as key added values carried by BGs in the treatment of burn injuries. However, some issues deserve careful consideration while proceeding with the research, including the selection of suitable BG compositions, appropriate forms of application (e.g., BG fibers, ointments or composite patches), as well as the procedures for reliable in vivo testing.

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In vitro bioactivity and antibacterial properties of bismuth oxide modified bioactive glasses

Abstract: Abstract

Cited by 28 publications

References 35 publications

Structure and Stability of High CaO- and P₂O₅-Containing Silicate and Borosilicate Bioactive Glasses

Structure and Stability of High CaO- and P₂O₅-Containing Silicate and Borosilicate Bioactive Glasses

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Using Bioactive Glasses in the Management of Burns

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In vitro bioactivity and antibacterial properties of bismuth oxide modified bioactive glasses

Abstract: Abstract

Cited by 28 publications

References 35 publications

Structure and Stability of High CaO- and P2O5-Containing Silicate and Borosilicate Bioactive Glasses

Structure and Stability of High CaO- and P2O5-Containing Silicate and Borosilicate Bioactive Glasses

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Using Bioactive Glasses in the Management of Burns

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Product

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About

Structure and Stability of High CaO- and P₂O₅-Containing Silicate and Borosilicate Bioactive Glasses

Structure and Stability of High CaO- and P₂O₅-Containing Silicate and Borosilicate Bioactive Glasses