Using Bioactive Glasses in the Management of Burns

Kargozar, Saeid; Mozafari, Masoud; Hamzehlou, Sepideh; Baino, Francesco

doi:10.3389/fbioe.2019.00062

Cited by 55 publications

(49 citation statements)

References 115 publications

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“…Up to now, different types of natural and synthetic substances have been developed and applied for managing skin wounds; all could be categorized into three groups, including bioactive, interactive, and passive [ 97 , 98 ]. CNPs as bioactive materials have been introduced as remarkable therapeutics for skin tissue repair and regeneration [ 99 , 100 ].…”

Section: Nanoceria For Soft-tissue Engineeringmentioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

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Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.

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Section: Nanoceria For Soft-tissue Engineeringmentioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

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“…In particular, the aforementioned bioactive glasses have been used as a matrix for the controlled release of metal ions [ 84 , 85 ]. Figure 5 a illustrates the effects of different dissolution products of doped bioactive glasses on the wound healing cascade.…”

Section: Metal Oxide Nanoparticle Hybrid Materialsmentioning

confidence: 99%

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confidence: 99%

Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

2020

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Wound care and soft tissue repair have been a major human concern for millennia. Despite considerable advancements in standards of living and medical abilities, difficult-to-heal wounds remain a major burden for patients, clinicians and the healthcare system alike. Due to an aging population, the rise in chronic diseases such as vascular disease and diabetes, and the increased incidence of antibiotic resistance, the problem is set to worsen. The global wound care market is constantly evolving and expanding, and has yielded a plethora of potential solutions to treat poorly healing wounds. In ancient times, before such a market existed, metals and their ions were frequently used in wound care. In combination with plant extracts, they were used to accelerate the healing of burns, cuts and combat wounds. With the rise of organic chemistry and small molecule drugs and ointments, researchers lost their interest in inorganic materials. Only recently, the advent of nano-engineering has given us a toolbox to develop inorganic materials on a length-scale that is relevant to wound healing processes. The robustness of synthesis, as well as the stability and versatility of inorganic nanotherapeutics gives them potential advantages over small molecule drugs. Both bottom-up and top-down approaches have yielded functional inorganic nanomaterials, some of which unite the wound healing properties of two or more materials. Furthermore, these nanomaterials do not only serve as the active agent, but also as the delivery vehicle, and sometimes as a scaffold. This review article provides an overview of inorganic hybrid nanotherapeutics with promising properties for the wound care field. These therapeutics include combinations of different metals, metal oxides and metal ions. Their production, mechanism of action and applicability will be discussed in comparison to conventional wound healing products.

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“…3 Moreover, the burnt skin loses its protective function, becoming the perfect environment for bacterial growth. 4 In fact, phenomena such as infection and chronic inflammation can undermine a successful healing of the tissue. 5,6 In the past decade, the design of smart dressings able to accelerate the skin burn healing process by providing antibacterial, antioxidant or anti-inflammatory features has been intensively pursued.…”

Section: Introductionmentioning

confidence: 99%