In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple

Zhu, Qin; Zhang, Natalie Qishan; Lau, Chi Fai; Chao, Jianfei; Sun, Zheng; Chang, Raymond Chuen‐Chung; Chen, Feng; Wang, Mingfu

doi:10.1016/j.foodchem.2012.06.053

Cited by 25 publications

(18 citation statements)

References 27 publications

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“…In vitro study on GT17 immortalised hypothalamic neurons has proved that PHL influences membrane properties namely fluidity as well as potential and significantly decreased intracellular calcium level, thus reduced the excitotoxicity (Kawahara and Kuroda, 2001). Also, PHL being potent antioxidant, decreased lactate dehydrogenase release in acrolein challenged human neuroblastoma SH-SY5Y cells which demonstrated its cytoprotective effect (Zhu Q et al, 2012). In addition, PHL was found to possess anti-inflammatory effect since it reduced proinflammatory cytokine and mediators levels in RAW264.7 cells .…”

Section: Accepted Manuscriptmentioning

confidence: 87%

Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice

Ghumatkar

Patil

Jain

et al. 2015

Pharmacology Biochemistry and Behavior

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Section: Accepted Manuscriptmentioning

confidence: 87%

Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice

Ghumatkar

Patil

Jain

et al. 2015

Pharmacology Biochemistry and Behavior

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“…Enolate Hepatoprotection in Ischemia-Reperfusion adducts with acrolein, HNE, and other electrophilic unsaturated aldehydes that participate in oxidative stress-induced injury (LoPachin et al, 2011). Similarly, curcumin and other phytopolyphenols (e.g., phloretin, resveratrol) can ionize to form nucleophilic enolate sites that scavenge electrophilic aldehydes (Awasthi et al, 1996;Zhu et al, 2009Zhu et al, , 2012.…”

Section: Discussionmentioning

confidence: 99%

2-Acetylcyclopentanone, an Enolate-Forming 1,3-Dicarbonyl Compound, Is Cytoprotective in Warm Ischemia-Reperfusion Injury of Rat Liver

Kosharskyy

Vydyanathan

Zhang

et al. 2015

J Pharmacol Exp Ther

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We have previously shown that 2-acetylcyclopentanone (2-ACP), an enolate-forming 1,3-dicarbonyl compound, provides protection in cell culture and animal models of oxidative stress. The pathophysiology of ischemia-reperfusion injury (IRI) involves oxidative stress, and, therefore, we determined the ability of 2-ACP to prevent this injury in a rat liver model. IRI was induced by clamping the portal vasculature for 45 minutes (ischemia phase), followed by recirculation for 180 minutes (reperfusion phase). This sequence was associated with substantial derangement of plasma liver enzyme activities, histopathological indices, and markers of oxidative stress. The 2-ACP (0.80-2.40 mmol/kg), administered by intraperitoneal injection 10 minutes prior to reperfusion, provided dose-dependent cytoprotection, as indicated by normalization of the IRI-altered liver histologic and biochemical parameters. The 2-ACP (2.40 mmol/kg) was also hepatoprotective when injected before clamping the circulation (ischemia phase). In contrast, an equimolar dose of N-acetylcysteine (2.40 mmol/kg) was not hepatoprotective when administered prior to reperfusion. Our studies to date suggest that during reperfusion the enolate nucleophile of 2-ACP limits the consequences of mitochondrialbased oxidative stress through scavenging unsaturated aldehyde electrophiles (e.g., acrolein) and chelation of metal ions that catalyze the free radical-generating Fenton reaction. The ability of 2-ACP to reduce IRI when injected prior to ischemia most likely reflects the short duration of this experimental phase (45 minutes) and favorable pharmacokinetics that maintain effective 2-ACP liver concentrations during subsequent reperfusion. These results provide evidence that 2-ACP or an analog might be useful in treating IRI and other conditions that have oxidative stress as a common molecular etiology.

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“…Conversely, epigallocatechin-3-gallate has a direct trapping agent of RCCs that has been suggested to also contribute to the significant reduction of acrolein and other aldehydes in the peroxidation of seal blubber oil [74]. A similar study highlighted that an apple phenolic compound, phloretin, is a promising candidate in the prevention or treatment of acrolein-associated human diseases [75]. Phenolics are also important in the inhibition of cellular nitosative stress as demonstrated widely.…”

Section: The Natural Regulators Of Cellular Redox Homeostasis and Promentioning

confidence: 94%

Natural products and the aging process

Ergin

Bali²,

Hariry

et al. 2013

Hormone Molecular Biology and Clinical Investigation

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Literature surveys show that the most of the research that have been conducted on the effect of herbal remedies on many tissue pathologies, including metabolic disturbances, cardiovascular decline, neurodegeneration, cataract, diabetic retinopathy and skin inflammation, all lead to an accelerated aging process. The increased carbonylation of proteins (carbonyl stress) disturbing their function has been indicated as an underlying mechanism of cellular senescence and age-related diseases. Because it is also linked to the carbonyl stress, aging chronic disease and inflammation plays an important role in understanding the clinical implications of cellular stress response and relevant markers. Greater knowledge of the molecular and cellular mechanisms involved in several pathologies associated with aging would provide a better understanding to help us to develop suitable strategies, use specific targets to mitigate the effect of human aging, prevent particularly chronic degenerative diseases and improve quality of life. However, research is lacking on the herbal compounds affecting cellular aging signaling as well as studies regarding the action mechanism(s) of natural products in prevention of the age-related disease. This review provides leads for identifying new medicinal agents or potential phytochemical drugs from plant sources for the prevention or delaying cellular aging processes and the treatment of some disorders related with accelerated body aging.

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In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple

Cited by 25 publications

References 27 publications

Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice

Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice

2-Acetylcyclopentanone, an Enolate-Forming 1,3-Dicarbonyl Compound, Is Cytoprotective in Warm Ischemia-Reperfusion Injury of Rat Liver

Natural products and the aging process

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