In Vitro Atrial Septal Ablation Using High-Intensity Focused Ultrasound

Takei, Yasuyoshi; Muratore, Robert; Kalisz, Andrew; Okajima, Kazue; Fujimoto, Kohei; Hasegawa, Takuya; Arai, Kotaro; Rekhtman, Yelena; Berry, Grace; Tullio, Marco R. Di; Homma, Shunichi

doi:10.1016/j.echo.2011.12.010

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…Different studies have already illustrated the possibility to use HIFU for pre-clinical and clinical cardiac applications such as: treatment of arrhythmias [36,37], atrial septostomy [38] or atrio-ventricular nodal-ablation in dogs [39]. Therefore, the developed 4-D US platform can be considered as dual-mode, imaging and therapy.…”

Section: Discussionmentioning

confidence: 99%

Fast Volumetric Ultrasound B-Mode and Doppler Imaging with a New High-Channels Density Platform for Advanced 4D Cardiac Imaging/Therapy

et al. 2018

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Abstract:A novel ultrasound (US) high-channels platform is a pre-requisite to open new frontiers in diagnostic and/or therapy by experimental implementation of innovative advanced US techniques. To date, a few systems with more than 1000 transducers permit full and simultaneous control in both transmission and receiving of all single elements of arrays. A powerful US platform for implementing 4-D (real-time 3-D) advanced US strategies, offering full research access, is presented in this paper. It includes a 1024-elements array prototype designed for 4-D cardiac dual-mode US imaging/therapy and 4 synchronized Vantage systems. The physical addressing of each element was properly chosen for allowing various array downsampled combinations while minimizing the number of driving systems. Numerical simulations of US imaging were performed, and corresponding experimental data were acquired to compare full and downsampled array strategies, testing 4-D imaging sequences and reconstruction processes. The results indicate the degree of degradation of image quality when using full array or downsampled combinations, and the contrast ratio and the contrast to noise ratio vary from 7.71 dB to 2.02 dB and from 2.99 dB to −7.31 dB, respectively. Moreover, the feasibility of the 4-D US platform implementation was tested on a blood vessel mimicking phantom for preliminary Doppler applications. The acquired data with fast volumetric imaging with up to 2000 fps allowed assessing the validity of common 3-D power Doppler, opening in this way a large field of applications.

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Section: Discussionmentioning

confidence: 99%

Fast Volumetric Ultrasound B-Mode and Doppler Imaging with a New High-Channels Density Platform for Advanced 4D Cardiac Imaging/Therapy

et al. 2018

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“…In the future, we anticipate seeing attempts to create a septostomy noninvasively by means of histotripsy, which is an ultrasonic technique that produces nonthermal, mechanical tissue fractionation through the use of high-intensity ultrasound pulses [76,77]. In a pilot study, Xu et al applied this technique to create an atrial septal defect in an open chest model in dogs [76].…”

Section: Non-invasive Creation Of An Atrial Septal Defectmentioning

confidence: 99%

“…With this treatment they were able to produce a right-to-left interatrial shunt in 9 of the 10 dogs, without significant damage to the surrounding tissues. Takey et al have also been developing this approach in alternative animal models with similar satisfactory results [77]. However, human trials are warranted.…”

Section: Non-invasive Creation Of An Atrial Septal Defectmentioning

confidence: 99%

Interventional and surgical therapeutic strategies for pulmonary arterial hypertension: Beyond palliative treatments

Sandoval

Gomez-Arroyo

Gaspar

et al. 2015

Journal of Cardiology

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Despite significant advances in pharmacological treatments, pulmonary arterial hypertension remains an incurable disease with an unreasonably high morbidity and mortality. Although specific pharmacotherapies have shifted the survival curves of patients and improved exercise endurance as well as quality of life, it is also true that these pharmacological interventions are not always accessible (particularly in developing countries) and, perhaps most importantly, not all patients respond similarly to these drugs. Furthermore, many patients will continue to deteriorate and will eventually require an additional, non-pharmacological, intervention. In this review we analyze the role of atrial septostomy and Potts anastomosis in the management of patients with pulmonary arterial hypertension, we summarize the current worldwide clinical experience (case reports and case series), and discuss why these interventional/surgical strategies might have a therapeutic role beyond that of a "bridge" to transplantation.

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“…The thermal effects of HIFU have also been investigated for non-invasive ligation of mitral chordae (for treatment of functional mitral regurgitation) [45], atrial septostomy [46, 47], creation of ventricular septal defects (for palliation of cyanotic congenital heart disease) [48], and atrio-ventricular nodal ablation [49] in dog and ex vivo models.…”

Section: Cardiovascular Applicationsmentioning

confidence: 99%

Cardiovascular applications of therapeutic ultrasound

Nazer

Gerstenfeld

Hata

et al. 2013

J Interv Card Electrophysiol

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Ultrasound (US) has gained widespread use in diagnostic cardiovascular applications. At amplitudes and frequencies typical of diagnostic use, its biomechanical effects on tissue are largely negligible. However, these parameters can be altered to harness US’s thermal and non-thermal effects for therapeutic indications. High-intensity focused ultrasound (HIFU) and extracorporeal shock wave therapy (ECWT) are two therapeutic US modalities which have been investigated for treating cardiac arrhythmias and ischemic heart disease, respectively. Here, we review the biomechanical effects of HIFU and ECWT, their potential therapeutic mechanisms, and pre-clinical and clinical studies demonstrating their efficacy and safety limitations. Furthermore, we discuss other potential clinical applications of therapeutic US and areas in which future research is needed.

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In Vitro Atrial Septal Ablation Using High-Intensity Focused Ultrasound

Cited by 8 publications

References 28 publications

Fast Volumetric Ultrasound B-Mode and Doppler Imaging with a New High-Channels Density Platform for Advanced 4D Cardiac Imaging/Therapy

Fast Volumetric Ultrasound B-Mode and Doppler Imaging with a New High-Channels Density Platform for Advanced 4D Cardiac Imaging/Therapy

Interventional and surgical therapeutic strategies for pulmonary arterial hypertension: Beyond palliative treatments

Cardiovascular applications of therapeutic ultrasound

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