Cardiovascular applications of therapeutic ultrasound

Nazer, Babak; Gerstenfeld, Edward P.; Hata, Akiko; Crum, Lawrence A.; Matula, Thomas J.

doi:10.1007/s10840-013-9845-z

Cited by 19 publications

(12 citation statements)

References 49 publications

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“…As these sound waves propagate through tissues, the energy is partially absorbed and partially reflected by intervening media. Absorption of the ultrasound waves by tissue causes increased local temperatures, which leads to coagulation, liquefactive necrosis, tissue vaporization, or some combination effects . In addition to physical effects, ultrasound treatment also shows some biological effects.…”

Section: Discussionmentioning

confidence: 99%

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Exosomes Derived From Low‐Intensity Pulsed Ultrasound‐Treated Dendritic Cells Suppress Tumor Necrosis Factor–Induced Endothelial Inflammation

Lin

et al. 2018

J of Ultrasound Medicine

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Objectives Endothelial cell inflammation plays an important role in atherosclerosis. Low‐intensity pulsed ultrasonography (LIPUS) exerts an anti‐inflammatory function on endothelial cells, whereas the underlying mechanism has not been fully elucidated. Methods Bone marrow dendritic cells (BMDCs) derived from bone barrow cells were treated with LIPUS, and exosomes secreted into the supernatant were purified. The isolated exosomes were incubated with human umbilical vein endothelial cells (HUVECs) to investigate their effect on tumor necrosis factor (TNF)‐α–induced endothelial inflammation. Ultrastructure was analyzed by transmission electron microscopy. Messenger RNA levels were determined by quantitative reverse transcription polymerase chain reaction, and protein levels were analyzed by western blot. Results The isolated exosomes presented a typical exosomal size of 30 to 100 nm in diameter and expressed exosome positive markers (Alix, CD63, and TSG101) but not the exosome negative marker (Calnexin). Exosomes derived from LIPUS‐treated BMDCs were rich in miR‐16 and miR‐21, which could be engulfed by HUVECs. Pretreatment with exosomes impeded TNFα‐induced HUVEC activation and downregulated TNFα‐stimulated expression of vascular cell adhesion molecule‐1 and intercellular adhesion molecule‐1, thus preventing TNFα‐induced activation of the nuclear factor‐κB signaling pathway. Conclusion Exosomes derived from LIPUS‐treated BMDC inhibit TNFα‐induced endothelial inflammation by inhibiting the nuclear factor‐κB signaling pathway.

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Section: Discussionmentioning

confidence: 99%

“…Ultrasound has gained widespread use in diagnostic cardiovascular applications . Low‐intensity pulsed ultrasound (LIPUS) has the ability to elicit anti‐inflammatory responses via various mechanisms .…”

mentioning

confidence: 99%

Exosomes Derived From Low‐Intensity Pulsed Ultrasound‐Treated Dendritic Cells Suppress Tumor Necrosis Factor–Induced Endothelial Inflammation

Lin

et al. 2018

J of Ultrasound Medicine

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“…Because it does not require direct contact with the target tissue, it is free from typical anatomic constraints. It has been used in humans for atrial fibrillation ablation (using balloon‐tipped catheters), and is under development for a variety of cardiac conditions …”

Section: Novel Procedural Techniques For Hypertrophic Cardiomyopathymentioning

confidence: 99%

“…It has been used in humans for atrial fibrillation ablation (using balloon-tipped catheters), and is under development for a variety of cardiac conditions. 96 The use of HIFU to create intramyocardial lesions was first demonstrated in an ex-vivo study in which 2 to 6 mm focal lesions were produced in the mid-myocardial wall without damage to surrounding tissues. 97 It was later demonstrated to be feasible in vivo with application of thoracotomy-based HIFU from the right ventricular surface, 98 and more recently from a closed-chest, transthoracic approach with successful ablations performed up to 9 mm in size in the intraventricular septum of live canines.…”

Section: High-intensity Focused Ultrasoundmentioning

confidence: 99%

Hypertrophic cardiomyopathy: the future of treatment

Tuohy

Kaul

Song

et al. 2020

European J of Heart Fail

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121

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Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic disorder most often caused by sarcomeric mutations resulting in left ventricular hypertrophy, fibrosis, hypercontractility, and reduced compliance. It is the most common inherited monogenic cardiac condition, affecting 0.2% of the population. Whereas currently available therapies for HCM have been effective in reducing morbidity, there remain important unmet needs in the treatment of both the obstructive and non‐obstructive phenotypes. Novel pharmacotherapies directly target the molecular underpinnings of HCM, while innovative procedural techniques may soon offer minimally‐invasive alternatives to current septal reduction therapy. With the advent of embryonic gene editing, there now exists the potential to correct underlying genetic mutations that may result in disease. This article details the recent developments in the treatment of HCM including pharmacotherapy, septal reduction procedures, mitral valve manipulation, and gene‐based therapies.

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“…13 HIU allows delivery of deep lesions with minimal effect on superficial tissue and structures, thus providing an attractive energy source for catheter ablation of NICMP VT.…”

mentioning

confidence: 99%

Epicardial Catheter Ablation Using High-Intensity Ultrasound

Nazer

Salgaonkar

Diederich

et al. 2015

Circ: Arrhythmia and Electrophysiology

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Background-Epicardial radiofrequency catheter ablation of ventricular tachycardia remains challenging because of the presence of deep myocardial scar and adjacent cardiac structures, such as the coronary arteries, phrenic nerve, and epicardial fat that limit delivery of radiofrequency energy. High-intensity ultrasound (HIU) is an acoustic energy source able to deliver deep lesions through fat, while sparing superficial structures. We developed and tested an epicardial HIU ablation catheter in a closed chest, in vivo swine model. Methods and Results-The

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Cardiovascular applications of therapeutic ultrasound

Cited by 19 publications

References 49 publications

Exosomes Derived From Low‐Intensity Pulsed Ultrasound‐Treated Dendritic Cells Suppress Tumor Necrosis Factor–Induced Endothelial Inflammation

Exosomes Derived From Low‐Intensity Pulsed Ultrasound‐Treated Dendritic Cells Suppress Tumor Necrosis Factor–Induced Endothelial Inflammation

Hypertrophic cardiomyopathy: the future of treatment

Epicardial Catheter Ablation Using High-Intensity Ultrasound

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