In vitro assessment of mixed matrix hemodialysis membrane for achieving endotoxin-free dialysate combined with high removal of uremic toxins from human plasma

Geremia, Ilaria; Bansal, Ruchi; Stamatialis, Dimitrios

doi:10.1016/j.actbio.2019.04.009

Cited by 36 publications

(24 citation statements)

References 52 publications

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“…Recently, Geremia et al investigated an application of MMM for achieving endotoxin-free dialysate along with simultaneous high removal of uremic toxins with a single membrane (Fig. 10 ) [ 71 ]. The safety-barrier properties of MMMs in preventing transfer of pyrogens to the plasma have been revealed by analyzing inflammation in THP-1 monocytes incubated with dialysate that was contaminated by bacteria.…”

Section: Biomedical Materials For Toxin Removalmentioning

confidence: 99%

Recent trends in therapeutic application of engineered blood purification materials for kidney disease

et al. 2022

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Blood purification is a commonly used method to remove excess metabolic waste in the blood in renal replacement therapy. The sufficient removal of these toxins from blood can reduce complications and improve survival lifetime in dialysis patients. However, the current biological blood purification materials in clinical practice are not ideal, where there is an unmet need for producing novel materials that have better biocompatibility, reduced toxicity, and, in particular, more efficient toxin clearance rates and a lower cost of production. Given this, this review has carefully summarized newly developed engineered different structural biomedical materials for blood purification in terms of types and structure characteristics of blood purification materials, the production process, as well as interfacial chemical adsorption properties or mechanisms. This study may provide a valuable reference for fabricating a user-friendly purification device that is more suitable for clinical blood purification applications in dialysis patients. Graphical Abstract

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Section: Biomedical Materials For Toxin Removalmentioning

confidence: 99%

Recent trends in therapeutic application of engineered blood purification materials for kidney disease

et al. 2022

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“…[58][59][60] The recent development of a mixed matrix hemodialysis membrane in which activated carbon is incorporated in to the membrane material represents a technical advance along these lines. 61 The performance of mixed matrix membranes could potentially be enhanced by an "outsidein" design, with dialysate flowing through hollow fibers while blood flows outside the fibers. 62 While activated carbon has been the sorbent most commonly considered for addition to the dialysate stream, other materials could provide special benefits or greater safety.…”

Section: Protein-bound Solutesmentioning

confidence: 99%

Improving Clearance for Renal Replacement Therapy

2021

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The adequacy of hemodialysis is now assessed by measuring the removal of the single solute urea. The urea clearance provided by current dialysis methods is a large fraction of the blood flow through the dialyzer, and therefore cannot be increased much further. Other solutes which are less effectively cleared than urea may however contribute more to the residual uremic illness suffered by hemodialysis patients. We here review a variety of methods which could be employed to increase the clearance of such non-urea solutes. New clinical studies will be required to test the extent to which increasing solute clearances improves patients' health.

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“…In contrast to other sorption‐based technologies, relatively small sorbent particles (between 20 and 40 microns) are incorporated into the MMM resulting in increased available surface area for toxin adsorption combined to low transmembrane pressure. Recent studies 38 showed that the dual layer hollow fiber MMMs can remove significantly more protein‐bound toxins compared to benchmark membranes. Besides, the MMM can also be applied for removal of uremic toxins combined to achieving endotoxin‐free dialysate and prevent transfer of endotoxins to the patients plasma in vitro.…”

Section: Innovations In Hd Membranesmentioning

confidence: 99%

“…Reprinted from “Mixed matrix HD membrane for achieving endotoxin‐free dialysate combined with high removal of uremic toxins from human plasma.” Reprinted from ref. 38, with permission from Elsevier [Color figure can be viewed at wileyonlinelibrary.com]…”

Section: Innovations In Hd Membranesmentioning

confidence: 99%

Frontiers in hemodialysis: Innovations and technological advances

et al. 2020

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As increasing demand for hemodialysis (HD) treatment incurs significant financial burden to healthcare systems and ecological burden as well, novel therapeutic approaches as well as innovations and technological advances are being sought that could lead to the development of purification devices such as dialyzers with improved characteristics and wearable technology. Novel knowledge such as the development of more accurate kinetic models, the development of novel HD membranes with the use of nanotechnology, novel manufacturing processes, and the latest technology in the science of materials have enabled novel solutions already marketed or on the verge of becoming commercially available. This collaborative article reviews the latest advances in HD as they were presented by the authors in a recent symposium titled “Frontiers in Haemodialysis,” held on 12th December 2019 at the Royal Society of Medicine in London.

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In vitro assessment of mixed matrix hemodialysis membrane for achieving endotoxin-free dialysate combined with high removal of uremic toxins from human plasma

Cited by 36 publications

References 52 publications

Recent trends in therapeutic application of engineered blood purification materials for kidney disease

Recent trends in therapeutic application of engineered blood purification materials for kidney disease

Improving Clearance for Renal Replacement Therapy

Frontiers in hemodialysis: Innovations and technological advances

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