In vitro application of Fe/MgO nanoparticles as magnetically mediated hyperthermia agents for cancer treatment

Exploring multifunctional potential of commercial ferrofluids by magnetic particle hyperthermia

“…Brownian relaxation refers to the rotation of nanoparticle inside the medium (water in our case) when exposed to an external applied field and its contribution to the total amount of resulted heat depends on the ability to perform this movement. The measurements protocol followed in present work, is the widely accepted protocol for the hyperthermia measurements, starting with the measurements of the solution as described in detail in our previous publications [14,15,18]. Currently, we are examining selected high-performance commercial samples in vitro prior to their in vivo evaluation, in an effort to examine the decrease of SAR efficiency when MNPs are immobilized within cells, due to Brownian contribution attenuation [19].…”

“…Generally, nanoparticles as heating mediators should have the highest possible SAR values resulting to the smallest amount of MNPs to be targeted to the tumor. Since heat mediation may occur also via nonmagnetic pathways, in order to exclude thermal exchange with the environment and isolate the magnetic-origin heating contribution, we have incorporated in SAR calculation a set of adiabatic corrections (by subtracting the solvent signal prior to fitting the cooling curve to provide the law of cooling), as described in detail in our previous works [14,15]. The energy dissipation rate (as shown in Eq.…”

Can commercial ferrofluids be exploited in AC magnetic hyperthermia treatment to address diverse biomedical aspects?

“…[7,8] The hyperthermia efficiency is evaluated by measuring the specific loss power (SLP), which refers to the amount of energy converted into heat (W) per time (Dt) and mass of the magnetic material (Fe 3 O 4 in this case). [9] 3 Results and Discussion…”

“…In all cases an identical sequence is initially recorded for a pure aqueous (solvent) solution and used as reference to exclude heating exchange with the environment and eventually quantify accurately magnetic heating response via estimation of Specific Loss Power (SLP) values. [9] The shaded areas denote the desirable hyperthermia levels (41-45 o C) required for a successful hyperthermal cell-shock. It seems that the LF requires a higher concentration of MNPs in order to provide a reliable result.…”

In vitro evaluation of PEGylated mesoporous MgFe2O4 magnetic nanoassemblies (MMNs) for chemo-thermal therapy

“…28,29 In order to use DOX-MMNs for chemo-thermal therapy, the heating efficiency of MMNs was evaluated under an AMF with a frequency of 425 kHz and strengths of 7 and 10 kA m À1 s À1 (Fig. 6a) at a xed frequency of 425 kHz.…”