In vitro evaluation of PEGylated mesoporous MgFe2O4 magnetic nanoassemblies (MMNs) for chemo-thermal therapy

PEGylated FePt–Fe3O4 composite nanoassemblies (CNAs): in vitro hyperthermia, drug delivery and generation of reactive oxygen species (ROS)

“…Also, such observations have been reported in many different systems 3,29,30. The higher cumulative drug release efficiency in the acidic conditions might be due to the presence of -COOgroup on the surface of CNAs which has the higher affinity towards abundant H + COOgroup could be partially neutralized by H + ions and eventually the electrostatic interaction between the DOX and -COOon the surface of CNAs is weak.Alternatively, as the pKa value of carboxylate group is about ~ 4.8 and hence carboxylate group may be dissociated in the solution (~ pH = 4.3).…”

Colloidal magnetic nanocrystal clusters: variable length-scale interaction mechanisms, synergetic functionalities and technological advantages

“…Among them, toxicity, stability, and site-specific binding are factors that should be taken into account by means of rational choice of the capping shell during the carrier developing stages. Ferrite nanoclusters, well-dispersed and stable in a physiological media have been studied for their potential use as nanocarriers in magnetically controlled drug delivery by encapsulating chemically diverse drug agents; some of them include ibuprofen (typical antiflammatory drug) [35], tamoxifen citrate (anti-estrogen drug for the treatment of breast cancer) [95], doxorubicin (anticancer drug) [29,33,95], multicationic drug gentamicin (aminoglycoside antibiotic) [24], and paclitaxel (anticancer drug) [26]. Bearing in mind the porous-like structure of the nanoscale clusters, their ability to enhance the drugloading efficacy (up to ~40% wt) has also been demonstrated [24,26].…”

“…A metallic precursor, such as metal chlorides [14-16, 25, 26, 28, 31, 33, 35, 77-87] or acetylacetonates [36,[88][89][90] are dissolved in a solvent like ether [36,[88][89][90], or glycol [14,15,25,26,31,33,35,77,[79][80][81][82][83][84][85][86][87], or water [16], or THF-ethanol [28] in a glass flask equipped with a heating mantle or in an autoclave (Figure 2A-E). A capping agent is also added in the reaction mixture at room temperature (Table 1) to control the size and the shape of the system.…”

“…Different morphologies, compact or loose structures with diameters ranging from 30 to a few hundred nm have been obtained with the previous synthesis strategies. Colloidal assemblies of inorganic nanocrystals are commonly called nanoclusters [15,[21][22][23][24][25][26][27][28][29], but in the literature, they can also be found as nanoflowers [30], nanoroses [17], multi-core particles [31,32], nanoassemblies [13,14,33,34], porous particles [35], flower-like mesocrystals [36], nanobeads [37,38], and pomegranate-like particles [34]. Furthermore, it is worth noting that these can be delivered with diverse chemical origin, including nanoclusters of ZnO [39,40], Co 3 O 4 [41], CuO [42], In 2 O 3 [40], CoO [40], MnO [40], ZnSe [40], CuCr 2 S 4 [43], PbS [44], and TiO 2 [45].…”

Magnetic hyperthermia application of MnFe2O4 nanostructures processed through solvents with the varying boiling point

“…In recent years, many studies are reported related to different size and shapes of inorganic metal, metal oxides and semiconductor NPs [1][2][3][4][5][6]. For biomedical applications, magnetic particles among inorganic NPs are highly interested particularly for drug delivery, magnetic resonance imaging and hyperthermia [7][8][9][10][11][12][13]. Magnetic ferrites have unique magnetic, optical, electronic and catalytic properties due to their spinel structure (AB 2 O 4 ) where A and B are tetrahedral and octahedral cation sites and O denotes the oxygen in anion sites.…”