In vitro antiviral effects of Peganum harmala seed extract and its total alkaloids against Influenza virus

Moradi, Mohammad-Taghi; Karimi, Ali; Rafieian-Kopaei, Mahmoud; Fotouhi, Fatemeh

doi:10.1016/j.micpath.2017.06.014

Cited by 69 publications

(45 citation statements)

References 33 publications

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“…[ [79][80][81] Anti-inflammatory effects a. Harmine reduced inflammatory cytokines. b. Harmine averted inflammatory damage in the lung of LPS (lipopolysaccharides)challenged mouse.…”

Section: Discussionmentioning

confidence: 99%

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

2021

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Background Medicinal plants are potential source of natural products that play an important role in preventing different human diseases. P. harmala is used traditionally as emmenagogue and an abortifacient agent in the Middle East, North of Africa and West of China. It belongs to the family of Zygophyllaceae and it is a wild growing flowering plant. Its seeds are main medicinal part of the plant. Methods The current searching was done by the keywords in main indexing systems including PubMed/MEDLINE, Scopus, and Institute for Scientific Information Web of Science as well as the search engine of Google Scholar. The keywords were wild rue, traditional medicine, Harman, health benefits, and pharmaceutical science. Results The most important uses of P. harmala in traditional pharmaceutical sciences are in cardiovascular, gasterointestinal, nervous, endocrine, neoplasm and tumors, pain relieving, organisms, diabetes, respiratory, disinfectant, anti-pyretic, skin and hair, rheumatism, arthritis and inflammation, and ulcers. Pharmacological effects of P. harmala are in cardiovascular system, nervous system, antimicrobial effects, antineoplasm, nervous system, endocrine, gastrointestinal effects, osteocytes, endocrine and respiratory system. Phenolic compounds are the main reason of antioxidant capacity. Conclusions Due to its pharmacological activities, P. harmala is a high potential medicinal herb and the suggestion is to increases by doing research in efficacy and safety.

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“…[ [79][80][81] Anti-inflammatory effects a. Harmine reduced inflammatory cytokines. b. Harmine averted inflammatory damage in the lung of LPS (lipopolysaccharides)challenged mouse.…”

Section: Discussionmentioning

confidence: 99%

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

2021

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“…Além de folhas e raízes, as sementes de plantas têm demonstrado em sua constituição fitoquímica substâncias antivirais promissoras, como por exemplo, sementes de Peganum harmala, uma Zygophyllaceae, que in vitro inviabilizou a replicação do vírus da gripe, pela síntese tardia de proteínas virais (Moradi et al, 2017). Diante disso, observa-se que dependendo do tipo de planta, algumas partes desta ou regiões inteiras, são passíveis de serem estudadas e seus princípios bioativos validados, objetivando conhecer substâncias que possam vir a ser utilizadas no combate a doenças virais (Farzaneh e Carvalho, 2015).…”

Section: Produtos Naturais Com Potencial Antiviralunclassified

“…A base dos estudos nessa temática são os metabólitos secundários (alcaloides, flavonoides e terpenoides) por exercerem papel fundamental na pesquisa por compostos antivirais bioativos, apresentando resultado promissor para a atividade antiviral de flavonoides isolados ou constituintes de extratos vegetais (Nolkemper et al, 2010;Moradi et al, 2017;Shikalepo et al, 2017). Diversas pesquisas já demonstraram a eficácia de compostos flavonoides exercendo atividade antiviral contra os mais diferentes vírus, inclusive retrovírus, como é o caso do CAEV (Dell'Aica et al, 2004;Wang et al, 2013;Zafar et al, 2013;Adianti et al, 2014;Santos et al, 2014;Zhang et al, 2014), pois certos tipos de flavonoides podem determinar inibição da transcriptase reversa (Ahmad et al, 2015).…”

Section: Produtos Naturais Com Potencial Antiviralunclassified

Perspectivas do uso de fitoterápicos no tratamento do sêmen caprino infectado pelo vírus da Artrite Encefalite Caprina

Peixoto¹,

Teixeira²,

Andrioli³

et al. 2018

Med. Vet. (UFRPE)

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A transmissão da artrite encefalite caprina pelo sêmen inviabiliza o uso de reprodutores soropositivos de alto valor genético. Como o vírus da artrite encefalite caprina (CAEV), é encontrado no sêmen na forma de RNA viral (vírus livre) ou DNA pró-viral dentro das células não espermáticas, possibilita que pesquisas com plantas com potencial antiviral sejam algo promissor para viabilizar o sêmen de reprodutores caprinos de grande valor zootécnico infectados. Diante disso, com essa revisão objetivou-se elucidar o potencial de fitocompostos, com comprovada ação antiviral, que poderiam vir a ser alvo de estudo para inativar o lentivírus caprino no sêmen. Inúmeras plantas de muitas famílias botânicas já foram estudadas para validação de efeito antiviral contra diversos vírus que acometem animais e humanos. Folhas, raízes, flores, e sementes demonstraram ao longo do tempo em sua constituição fitoquímica substâncias antivirais promissoras. De acordo com o tipo de planta, não apenas algumas partes dela, mas regiões inteiras da mesma são alvos das pesquisas por fitocompostos a ser usado como alternativa no combate as doenças virais. A base dos estudos nessa vertente são os metabólitos secundários, pois nas pesquisas têm apresentado compostos bioativos antivirais de alto potencial atuando nas diferentes fases do ciclo de desenvolvimento viral. Dessa forma, a biodiversidade da flora brasileira aliada à tendência de formar fitocompostos poderiam contribuir no avanço das pesquisas, a fim de encontrar uma alternativa de base natural, potencialmente eficaz, para eliminar os riscos de transmissão do CAEV pelo sêmen.

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“…Among the alkaloids that have antiviral activity, berberine has shown activity against the chikungunya virus, human cytomegalovirus (HCMV), and hepatitis C virus (HCV) [19][20][21], tomatidine against dengue virus (DV) [22], michellamine B against human immunodeficiency virus (HIV) [23], oxymatrine against influenza A virus [24], and palmatine against zika virus (ZV) [25]. In addition, plants rich in alkaloids also show antiviral action, such as the seeds of Peganum harmala L. that can inhibit influenza A virus [26] and root tubers of Stephania cepharantha Hayata that improve the survival of mice infected by herpes simplex virus type 1 (HSV1) [27].…”

Section: Introductionmentioning

confidence: 99%

Alkaloids: Therapeutic Potential against Human Coronaviruses

et al. 2020

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Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity and/or have been used as prototypes in the development of synthetic antiviral drugs. In this study, eleven anti-coronavirus alkaloids were identified from the scientific literature and their potential therapeutic value against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is discussed. In this study, in silico studies showed an affinity of the alkaloids for binding to the receptor-binding domain of the SARS-CoV-2 spike protein, putatively preventing it from binding to the host cell. Lastly, several mechanisms for the known anti-coronavirus activity of alkaloids were discussed, showing that the alkaloids are interesting compounds with potential use as bioactive agents against SARS-CoV-2.

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In vitro antiviral effects of Peganum harmala seed extract and its total alkaloids against Influenza virus

Cited by 69 publications

References 33 publications

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

Perspectivas do uso de fitoterápicos no tratamento do sêmen caprino infectado pelo vírus da Artrite Encefalite Caprina

Alkaloids: Therapeutic Potential against Human Coronaviruses

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