In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus

Cytotoxicity and potential antiviral evaluation of violacein produced by Chromobacterium violaceum

“…Various cell culture-based assays are available and can be successfully applied for the antiviral determination of synthetic or natural compounds (Vlietinck & Vanden Berghe 1998) which include visual quantitation of antiviral activity based upon the inhibition of the virus induced cytopathic effect (CPE) (Simões et al 1999, Semple et al 2001, Li et al 2002 or by less subjective measures, such as the colorimetric MTT assay (Takeuchi et al 1991, Kaneko et al 2001, Betancur-Galvis et al 2002 and fluorometric assays (Smee et al 2002).…”

Cellular Absorption of Anthraquinones Emodin and Chrysophanol in Human Intestinal Caco-2 Cells

“…7,8) Chrysophanol inhibits the replication of poliovirus types 2 and 3 (Picornaviridae) in vitro, which is related to its special structure with two hydrophobic positions on the chrysophanol molecule (C-6 and the methyl group attached to C-3). 9) These biological effects of emodin and chrysophanol are regarded as the underlying causes for the antiviral, anticancer, and vasorelaxant activities of hydroxyanthraquinones.…”

Anthraquinones and triterpenoids from Senna siamea (Fabaceae) Lam inhibit poliovirus activity

“…It has been stated that for a drug candidate to be considered as an anti-poliovirus drug, it must be able to inhibit the three strains of the virus (polioviruses 1, 2 and 3); chrysophanol is therefore a suitable drug candidate meeting this criterion, as it has earlier been shown by Semple and co-workers, that chrysophanol isolated from Daniella longifolia inhibits poliovirus 2 and 3 (Semple et al, 2001). This study has established its inhibitory properties against poliovirus 1 in vitro.…”