2003
DOI: 10.1590/s0074-02762003000600023
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Abstract: 42 ± 0.68%, 5.96 ± 2.51%, 5.13 ± 2.38 %, 8.18 ± 1.11% and 8.51 ± 1.94% for poliovirus type 2; 8.30 ± 4.24%; 13.33 ± 4.66% and 24.27 ± 2.18% for simian rotavirus SA11, at 0.312, 0.625 and 1.250 mM, respectively, when measured by the MTT assay.

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Cited by 173 publications
(120 citation statements)
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“…Medicinal plants have shown broad spectrum antiviral activities against RNA and DNA viruses [9,10], which could contribute as a promising candidate in controlling the life threatening viral infections [11]. Increased incidences of viral resistances and emergence of new viral diseases have led the scientists to explore for new anti-viral compounds [12,13].…”
Section: Introductionmentioning
confidence: 99%
“…Medicinal plants have shown broad spectrum antiviral activities against RNA and DNA viruses [9,10], which could contribute as a promising candidate in controlling the life threatening viral infections [11]. Increased incidences of viral resistances and emergence of new viral diseases have led the scientists to explore for new anti-viral compounds [12,13].…”
Section: Introductionmentioning
confidence: 99%
“…Currently, numerous researches are made, looking for natural sources of antibacterial, antifungal, antiviral and generally against diseases either on human or animals and plants [1,2]; secondary metabolites produced by microorganisms have proven to be resources with great biotechnological potential, being highly effective, safe, with fewer adverse effects than chemical growth conditions and also environmentally friendly [3][4][5]. Violacein is a purple pigment product of the secondary metabolism of bacteria, whose biological activities have been widely reported, including antimicrobial activity (antibacterial, antiviral, antiprotozoal and antifungal) [3,4,[6][7][8][9][10][11][12][13][14] anticancer activity [15][16][17][18][19] antioxidant activity [20] and recent studies also show insecticidal activity [5].…”
Section: Introductionmentioning
confidence: 99%
“…Violacein is a purple pigment product of the secondary metabolism of bacteria, whose biological activities have been widely reported, including antimicrobial activity (antibacterial, antiviral, antiprotozoal and antifungal) [3,4,[6][7][8][9][10][11][12][13][14] anticancer activity [15][16][17][18][19] antioxidant activity [20] and recent studies also show insecticidal activity [5]. Due to its biotechnological potential, numerous studies have been done indicating that Chromobacterium violaceum and Janthinobacterium lividum are primarily responsible for its synthesis [3][4][5]9,21,22]. Violacein has an indole derivative structure [8,15,17,18,21] characterized as C20-H13-N3-O3 [4,22,23].…”
Section: Introductionmentioning
confidence: 99%
“…It is a purple pigment which is insoluble in water but soluble in DMSO, methanol and ethyl acetate. It is a multifunctional compound with anti-inflammatory, anti-oxidant, anti-bacterial, anti-cancer and anti-parasitic properties [20][21][22]. The antioxidant property was studied by Konzen et al for nitrogen and oxygen reactive species, 1,1-diphenyl-2-picryl hydrazyl (DPPH) and hydroxyl radical and resulted in finding the reduction of free radicals in efficient way [18].…”
Section: Introductionmentioning
confidence: 99%
“…The antioxidant property was studied by Konzen et al for nitrogen and oxygen reactive species, 1,1-diphenyl-2-picryl hydrazyl (DPPH) and hydroxyl radical and resulted in finding the reduction of free radicals in efficient way [18]. Lipid peroxidation studies of violacein found protective effect on lipid membranes and also proved enhanced anti-oxidant property when reconstituted with membranes or liposomes as delivery systems [21,23]. Its anti-cancer property is well established in vitro due to its inhibiting potential against MMPs via cytokine inhibition in cancer cells, hence reducing tumor growth, metastasis, and angiogenesis.…”
Section: Introductionmentioning
confidence: 99%