In Vitro Antitumor and Anti-Inflammatory Activities of Allium-Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS)

Abstract

Increasing rates of cancer incidence and the side-effects of current chemotherapeutic treatments have led to the research on novel anticancer products based on dietary compounds. The use of Allium metabolites and extracts has been proposed to reduce the proliferation of tumor cells by several mechanisms. In this study, we have shown the in vitro anti-proliferative and anti-inflammatory effect of two onion-derived metabolites propyl propane thiosulfinate (PTS) and propyl propane thiosulfonate (PTSO) on several human tumor lines (MCF-7, T-84, A-549, HT-29, Panc-1, Jurkat, PC-3, SW-837, and T1-73). We observed that this effect was related to their ability to induce apoptosis regulated by oxidative stress. In addition, both compounds were also able to reduce the levels of some pro-inflammatory cytokines, such as IL-8, IL-6, and IL-17. Therefore, PTS and PTSO may have a promising role in cancer prevention and/or treatment.

Beneficial Effects of Daily Consumption of Garlic and Onion Extract Concentrate on Infectious Respiratory Diseases in Elderly Resident Volunteers

“…Thus, allicin from garlic is extremely unstable and is rapidly transformed in other compounds such as dithiins or diallyl disulfide [ 29 ], but other organosulfur compounds found in garlic, like alliin, can contribute to its beneficial effects due to the reported anti-inflammatory properties [ 30 ]. In onion, the most common sulfur compound is propiin (S-propyl-L-cysteine sulfoxide) that, due to the action of alliinase, leads to propiin derivatives, such as thiosulfinates and thiosulfonates compounds such as PTS and PTSO, which are more stable and exhibit interesting biological properties as antimicrobial, anti-inflammatory, or antitumor activities [ 31 , 32 , 33 ]. Although there is no evidence in the literature on its ability to prevent infectious processes in humans, there are many preclinical studies that support our results.…”

“…Onion is a food well known for its anti-inflammatory properties [ 44 ]. Some works have recently reported the anti-inflammatory effect of thiosulfinate and thiosulfonate from onion in human cells [ 33 ]. Besides, these compounds derived from propiin demonstrated in preclinical trials their ability to modulate the inflammatory response and their potential applications in bowel auto-immune diseases and intestinal infections [ 9 , 45 ].…”

The role of oil solutions of thiosulfonates in the modulation of antioxidant parameters in rat kidneys

“…Thiosulfonates can also find applications in the field of electrochemistry. They are used as electrolytes in batteries, electrolytic processes, and other electrochemical applications [7].…”