The role of oil solutions of thiosulfonates in the modulation of antioxidant parameters in rat kidneys

Abstract

This study investigated the influence of thiosulfonate esters, specifically S-ethyl-4-aminobenzenethiosulfonate (ETS), S-allyl-4-aminobenzenethiosulfonate (ATS), and S-allyl-4-acetylaminobenzenethiosulfonate (AATS), at a dose of 50 mg/kg body weight on the antioxidant defense system in rat kidneys. The kidneys are essential organs involved in maintaining metabolic homeostasis and they are constantly exposed to reactive oxygen species (ROS) and oxidative stress. The effectiveness of the antioxidant defense system was evaluated by measuring oxidative stress markers, including lipid peroxidation (LPO), as well as the activity of key antioxidant enzymes, such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GP), glutathione reductase (GR), and the level of reduced glutathione (GSH). Dysfunction of oxidant protection was observed with an oily diet, characterized by an increase in lipid hydroperoxide levels, a decrease in the SOD and catalase activity, and a decrease in the antioxidant activity of the entire glutathione chain. Administration of thiosulfonates, especially ETS and AATS, helped stabilize antioxidant protection. The beneficial antioxidant effects of thiosulfonates can be partially explained by their ability to prevent the formation of free radicals, can intercept, neutralize reactive oxygen species and other harmful substances that can damage body cells.