In vitro antiprotozoal activity and cytotoxicity of extracts and fractions from the leaves, root bark and stem bark of Isolona hexaloba

Muganza, Désiré Musuyu; Fruth, Barbara; Lami, José Nzunzu; Cos, Paul; Kanyanga, R. Cimanga; Maes, Louis; Pieters, Luc

doi:10.1016/j.jep.2015.07.034

Cited by 8 publications

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References 28 publications

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“…Most studies evaluate extract activity, fractions, and essential oils [38–48] . Among the articles that report the activity of isolated substances, some analyzed class are terpenes, which shows us that Annonaceae terpenes are potential antiepimastigote and antitrypomastigote agents [49–51] .…”

Section: Resultsmentioning

confidence: 99%

Natural Products from Annonaceae as Potential Antichagasic Agents

et al. 2022

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Chagas disease, a neglected tropical disease, is endemic in 21 Latin American countries and particularly prevalent in Brazil. Chagas disease has drawn more attention in recent years due to its expansion into non-endemic areas. The aim of this work was to computationally identify and experimentally validate the natural products from an Annonaceae family as antichagasic agents. Through the ligand-based virtual screening, we identified 57 molecules with potential activity against the epimastigote form of T. cruzi. Then, 16 molecules were analyzed in the in vitro study, of which, six molecules displayed previously unknown antiepimastigote activity. We also evaluated these six molecules for trypanocidal activity. We observed that all six molecules have potential activity against the amastigote form, but no molecules were active against the trypomastigote form. 13-Epicupressic acid seems to be the most promising, as it was predicted as an active compound in the in silico study against the amastigote form of T. cruzi, in addition to having in vitro activity against the epimastigote form.

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Section: Resultsmentioning

confidence: 99%