In-vitro antioxidative potential of different fractions from Prunus dulcis seeds: Vis a vis antiproliferative and antibacterial activities of active compounds

Dhingra, Naveen; Kar, Anand; Sharma, Rajesh; Bhasin, Sheetal

doi:10.1016/j.sajb.2016.10.013

Cited by 20 publications

(12 citation statements)

References 39 publications

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“…Our result is in agreement with other studies on other plants which have indicated a maximum average yield in aqueous fraction (Dhingra et al, 2017).…”

Section: Extraction and Fractionation Yieldsupporting

confidence: 94%

“…Benhamou et al (2009) showed that the acetate ethyl fraction of Atriplex halimus (Amaranthaceae family), exhibited a stronger antioxidant activity compared to butanolic fraction with IC50 values 1.73mg/ml (R 2 = 0.98) and 2.04 (R 2 = 0.99) mg/ml, respectively. Also, Dhingra et al (2017) observed a significant positive correlation between the total phenolic contents of Prunus dulcis and DPPH scavenging with R 2 = 0.931.In this study we found a significant correlation between the antioxidant activity and phenolic content with coefficient of determination (R 2 > 0, 91, p<0, 05) for all samples tested.…”

Section: Antioxidant Activitysupporting

confidence: 68%

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Antioxidant, antibacterial activities and phenolic content of organic fractions obtained from Chamaerops humilis L. leaf and fruit

2017

Int. J. Biosci.

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The use of plant extracts are the subject of numerous studies because, in addition to their use as preservatives in foodstuffs by replacing synthetic antioxidants, they are involved in the treatment of many diseases. This study investigated the antioxidant and antibacterial activities of Chamaerops humilis L. (Asteraceae) leaf and fruit, collected in north east of Algeria and their respective fractions, obtained using dichloromethane (DCMF), ethyl acetate (EAF), n-butanol (BF) and water (WF). The total phenolic and total flavonoids content was determined by the Folin-Ciocalteu and the aluminum chloride (2%) reaction, respectively. Antioxidant activity was measured, using different antioxidant assays (DPPH, FRAP, BCB). The antibacterial activities of the fractions were tested on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterococcus faecalis and Salmonella typhimurium. Two different methods were employed for the determination of antibacterial activities: disc diffusion method and minimum inhibitory concentrations (MICs).A significant correlation existed between concentrations of the extract and antioxidant activity since the maximum antioxidative activities were exhibited by ethyl acetate fraction [IC50=0.12 mg/ml (DPPH assay)] which has the highest levels of phenolic compounds (214,8±3,26 mg GAE/g fractions).Concerning antibacterial activity , the lowest activity was founded on the (WF)from fruits against Salmonella typhimurium (MIC=70mg/ml)and the highest was found on the (EA) fraction from leaves against Enterococcus faecalis (MIC=0,25 mg/ml) . These findings demonstrate the remarkable potential of this plant as new source of antioxidant ingredient with interesting antibacterial capacities.

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“…Our result is in agreement with other studies on other plants which have indicated a maximum average yield in aqueous fraction (Dhingra et al, 2017).…”

Section: Extraction and Fractionation Yieldsupporting

confidence: 94%

Section: Antioxidant Activitysupporting

confidence: 68%

Antioxidant, antibacterial activities and phenolic content of organic fractions obtained from Chamaerops humilis L. leaf and fruit

2017

Int. J. Biosci.

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“…Taking this into account, the acetonic almond seed extracts, with high concentrations of phenolic compounds, essentially containing phenolic acids and flavonoids, showed high antiproliferative effects on two different human breast cancer cell lines, MCF-7 and MDA-MB-468, exhibiting effective cytocidal concentrations at 10 µg/mL and >20 µg/mL, respectively [44]. In the same way, the aqueous bitter almond kernel extracts showed an impressive cytotoxicity in a dose-dependent manner against MCF-7 and human colon carcinoma cancer (HCT-116) cell lines, whereas the methanolic extracts of the same matrix promoted the highest cytotoxicity against human hepatocellular cancer cell line (HepG2), showing growth inhibitory concentrations (GI 50 ) of 29.5 µg/mL, 24.5 µg/mL, and 10.1 µg/mL, respectively [45].…”

Section: Anticancer Activitymentioning

confidence: 99%

Almond By-Products: Valorization for Sustainability and Competitiveness of the Industry

Barral-Martinez

Fraga-Corral

García-Pérez

et al. 2021

Foods

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The search for waste minimization and the valorization of by-products are key practices for good management and improved sustainability in the food industry. The production of almonds generates a large amount of waste, most of which is not used. Until now, almonds have been used for their high nutritional value as food, especially almond meat. The other remaining parts (skin, shell, hulls, etc.) are still little explored, even though they have been used as fuel by burning or as livestock feed. However, interest in these by-products has been increasing as they possess beneficial properties (caused mainly by polyphenols and unsaturated fatty acids) and can be used as new ingredients for the food, cosmetic, and pharmaceutical industries. Therefore, it is important to explore almond’s valorization of by-products for the development of new added-value products that would contribute to the reduction of environmental impact and an improvement in the sustainability and competitiveness of the almond industry.

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“…Recent evidence suggests that phenolic compounds and flavonoids have antimicrobial properties through a strong binding with microbial proteins and glycoproteins; thus the presence of these components can elucidate the antibacterial activity of almond. Pyrogallol, ethylgallate, and p-hydroxybenzoic acid are phenolic compounds isolated from almond seeds that have been shown to have strong antibacterial activity against Gram-positive and Gram-negative bacteria (Bolling, 2017;Dhingra et al, 2017;Mandalari et al, 2010). Moreover, the extract of blanched almond could inhibit growth of Escherichia coli, Serratia marcescens, and Streptococcus mutans colonies (Smeriglio et al, 2016).…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Almond as a nutraceutical and therapeutic agent in Persian medicine and modern phytotherapy: A narrative review

Karimi

Firouzi

Dadmehr

et al. 2020

Phytotherapy Research

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Sweet almond (Prunus dulcis (Mill.) D.A.Webb) is a known nut, which has long been used in several ethnomedical systems, especially in Persian medicine (PM) for its nutritional and therapeutic activities. In this study, we aimed to provide a summary on traditional uses, phytochemistry, and pharmacological activities of sweet almond.Thus, we reviewed textbooks of PM and electronic literature on traditional medicine.Moreover, the available data on the usage of sweet almond were searched in electronic databases to find articles on its pharmacological properties and phytochemistry. According to phytochemical investigations, this plant contains macronutrients, micronutrients, essential oils, various phenolic compounds, and phytosterols. Current pharmacological studies represent that Prunus dulcis has several biological activities including prebiotic, antimicrobial, antioxidant, antiinflammatory, anticancer, hepatoprotective, cardiometabolic protection, nootropic, anxiolytic, sedative-hypnotic, and nervous-improving effects. Further clinical trials and meta-analysis are required to draw a definitive conclusion on the efficacy and therapeutic activities of almond.

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In-vitro antioxidative potential of different fractions from Prunus dulcis seeds: Vis a vis antiproliferative and antibacterial activities of active compounds

Cited by 20 publications

References 39 publications

Antioxidant, antibacterial activities and phenolic content of organic fractions obtained from Chamaerops humilis L. leaf and fruit

Antioxidant, antibacterial activities and phenolic content of organic fractions obtained from Chamaerops humilis L. leaf and fruit

Almond By-Products: Valorization for Sustainability and Competitiveness of the Industry

Almond as a nutraceutical and therapeutic agent in Persian medicine and modern phytotherapy: A narrative review

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