In vitro antioxidant potentials of Cyperus rotundus L. rhizome extracts and their phytochemical analysis

Kamala, Arunagiri; Middha, Sushil Kumar; Gopinath, Chitra; Sindhura, H S; Karigar, Chandrakant S.

doi:10.4103/pm.pm_228_17

Cited by 35 publications

(8 citation statements)

References 24 publications

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“…Phenolic substances were widely identified in aqueous extracts of C. distans, C. laxus, and C. rotundus, both in phytochemical prospecting and in high-performance liquid chromatography (HPLC) analysis. Kamala et al (2018) observed chemical classes such as phenols, flavonoids, and saponins in the phytochemical prospecting of the aqueous extract of C. rotundus. Hema et al (2013) also verified the occurrence of these substances, except flavonoids, in the aqueous extract of C. rotundus by preliminary phytochemical prospecting.…”

Section: Discussionmentioning

confidence: 93%

Phytochemical Profile and Evaluation of the Allopathic Effect of Three Species of the Genus Cyperus (Cyperaceae)

Silva

Bezerra

Prata

et al. 2020

JAS

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The genus Cyperus is widely distributed worldwide and occurs in various regions of Brazil. Research has reported the allelopathic potential of species belonging to this genus. From this perspective, the present study analyzes the phytochemical profile and allelopathic effect of seven concentrations of the aqueous extracts of Cyperus distans L., Cyperus laxus Lam., and Cyperus rotundus L. The allelopathic potential was evaluated in triplicate from germination bioassays on seeds of two species, Lactuca sativa L. and Emilia fosbergii Nicolson. In addition, phytochemical analyses were performed to analyze possible allelochemicals present in aqueous extracts of three species by phytochemical screening and high-performance liquid chromatography (HPLC). The evaluated variables were: germination (G) and germination speed index (GSI). The data obtained were submitted to the F test, and regression analysis was performed to compare means. The results showed higher susceptibility of E. fosbergii to aqueous extracts of C. distans, C. laxus, and C. rotundus at all concentrations analyzed (0.94, 1.87, 3.75, 7.5, 15, and 30%). In turn, the germination rate of L. sativa seeds decreased only at the highest concentrations (between 15 and 30%) of the same extracts. This allelopathic potential may be directly associated with the biosynthetization of phenolic compounds by Cyperus spp., analyzed in this study by phytochemical prospecting and HPLC.

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Section: Discussionmentioning

confidence: 93%

Phytochemical Profile and Evaluation of the Allopathic Effect of Three Species of the Genus Cyperus (Cyperaceae)

Silva

Bezerra

Prata

et al. 2020

JAS

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“…Monomeric catechins also coexist with proanthocyanidins [35], m/z 577.13491, which are characterized by anthocyanidins (e.g., cyanidin) formed upon acid hydrolysis [36]. These compounds are related to antioxidant activity [37]. Procyanidin B2, m/z 579.15044, could also be identified, and it is associated with antioxidant activity and induction of keratinocyte differentiation, acting to restore skin barrier function [38].…”

Section: Resultsmentioning

confidence: 99%

Polyphenols, Antioxidants, and Wound Healing of Lecythis pisonis Seed Coats

Pimentel,

de Oliveira,

Pereira

et al. 2023

Planta Med

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To better use the Lecythis pisonis Cambess. biomass, this study investigates whether Sapucaia seed coats present wound-healing properties. We analyzed the antibacterial, antioxidant, and wound healing-promoting potentials, plus cytotoxicity and stimulation of VEGF-A. The chemical composition was analyzed by positive ion-mode electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI(+)FT-ICR MS). A total of 19 compounds were identified, such as proanthocyanidin A1, procyanidin A1, B2, C1, epigallocatechin, kaempferol (p-coumaroyl) glycoside, and kaempferol (p-coumaroyl) glycoside. Potent antioxidant strength/index was verified for DPPH (IC50 0.99 µg/mL) and FRAP (IC50 1.09 µg/mL). The extract did not present cytotoxicity and promoted significant cell migration and/or proliferation of fibroblasts (p<0.05). VEGF-A was stimulated dose-dependently, 6 µg/mL (167.13±8.30 pg/mL), 12.5 µg/mL (210.3±14.2 pg/mL) and 25 µg/mL (411.6±29.4 pg/mL), PDGF (0.002 µg/mL) stimulated 215.98 pg/mL. Staphylococcus aureus was susceptible to the extract, with a minimum inhibitory concentration (MIC) of 31.25 µg/mL. The identified compounds benefit the antioxidant activity, promoting hemostasis for the wound healing process, indicating that this extract has the potential for use in dermatological cosmetics. Keywords: Lecythis pisonis Cambess., Lecythidaceae, chemical analysis, wound healing. Abbreviations: DPPH (2,2-diphenyl-1-picrylhydrazyl radical), ESI(+)FT-ICR MS (Positive-ion mode electrospray ionization with Fourier transform ion cyclotron resonance mass spectrometry), FRAP (Ferric Reducing Antioxidant Power), GAE (Gallic acid equivalent), MIC (minimum inhibitory concentration), MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay, VEGF-A (vascular endothelial growth factor).

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“…Boswellia sacra in Ayurvedic medicine is considered as an astringent drug due to its compounds such as tannins and flavonoids (Siddiqui, 2011). Apart from Boswellia sacra , tannins and flavonoids are also found in various combinations of FHP such as C. rotundus , Q. infectoria , D. costus , P. nigrum , and Z. officinale (Abdallah, Qureshi, Ali, & Elhassan, 2017; Ahmad et al, 2015; Ghasemzadeh, Jaafar, & Rahmat, 2010; Kamala, Middha, Gopinath, Sindhura, & Karigar, 2018; Yusof & Abdullah, 2020). In studies on the medical treatment of MUI with the predominance of urge, and in UUI, the standard treatment is the use of antimuscarinics, including solifenacin; however, despite high efficacy of solifenacin, side effects such as palpitations, tachycardia, constipation, dry mouth and eyes, as well as abdominal pain make it difficult for patients to tolerate this drug and lead to discontinuation of the drug (Y. F. Yu, Nichol, Yu, & Ahn, 2005).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of frankincense‐based herbal product in urinary incontinence: A randomized, double‐blind, placebo‐ and active‐controlled clinical trial

Karbalaiee

Daneshpajooh

Khanjani

et al. 2022

Phytotherapy Research

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Urinary incontinence is a silent epidemic that has a serious impact on a person's quality of life (QOL). This study aimed to evaluate the efficacy of frankincense‐based herbal product (FHP) in urinary incontinence compared with placebo and solifenacin. In this randomized, double‐blind clinical trial, 120 postmenopausal women with mixed urinary incontinence were randomized to one of the three groups of FHP, placebo, and standard treatment (solifenacin). Frequency, amount of leakage, and score of urinary incontinence as well as the QOL were measured at the end of the second and fourth weeks and 2 weeks after the interruption of the treatment. The ICIQ‐UI SF and I‐QOL questionnaires were used for the measurements. Mean frequency of urinary incontinence and amount of leakage significantly decreased in the FHP and solifenacin groups in the fourth week compared to the placebo group. In addition, 2 weeks after treatment completion, the effects of the FHP were significant compared to the solifenacin group. Due to the effect of FHP on improving the QOL and also the prolonged effect of this drug, the use of FHP in urinary incontinence, as a complementary treatment could be suggested.

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In vitro antioxidant potentials of Cyperus rotundus L. rhizome extracts and their phytochemical analysis

Cited by 35 publications

References 24 publications

Phytochemical Profile and Evaluation of the Allopathic Effect of Three Species of the Genus Cyperus (Cyperaceae)

Phytochemical Profile and Evaluation of the Allopathic Effect of Three Species of the Genus Cyperus (Cyperaceae)

Polyphenols, Antioxidants, and Wound Healing of Lecythis pisonis Seed Coats

Efficacy of frankincense‐based herbal product in urinary incontinence: A randomized, double‐blind, placebo‐ and active‐controlled clinical trial

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