In vitro antioxidant potential of medicinal plant extracts and their activities against oral bacteria based on Brazilian folk medicine

Alviano, Wagner S.; Alviano, Daniela Sales; Diniz, Cláudio Galuppo; Antoniolli, Ângelo Roberto; Alviano, Celuta Sales; Farias, Luiz M.; Carvalho, Maria Auxiliadora Roque de; Souza, Margareth Maria Gomes de; Bolognese, Ana Maria

doi:10.1016/j.archoralbio.2007.12.001

Cited by 115 publications

(88 citation statements)

References 32 publications

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“…Several authors associated the antioxidant capacity of plant extracts with the antibacterial activity. Alviano et al (2008) reported that several Brazilian plants traditionally used against bacterial infections also present high antioxidant activity. Pattanayak & Sunita (2008) demonstrated that the synergistic effect of both …”

Section: Discussionmentioning

confidence: 99%

Antibacterial and antioxidant activities and acute toxicity of Bumelia sartorum Mart., Sapotaceae, a Brazilian medicinal plant

Ruela¹,

Leal²,

Almeida³

et al. 2011

Rev. bras. farmacogn.

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Abstract:In order to validate the Bumelia sartorum Mart., Sapotaceae, traditional use for infection diseases, this study evaluates the antibacterial activity of the stem bark fractions against methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus strains by using the agar dilution method and reported as MIC (minimal inhibitory concentration). In addition, the DPPH scavenging activity of these fractions was measured and the chemical composition and acute toxicity of the active fraction were also determined. The ethyl acetate (EtOAc) extract was chemically analyzed by LC/ MS, direct ionization APCI/MS, 1 H NMR and 13 C-NMR. All fractions, except butanol extract, presented high antioxidant activity, especially the methanol and the EtOAc extracts, which showed EC50 values (5.67 and 5.30 µg/mL, respectively) considerably lower than the Gingko-standard EGb 761 ® (38.58 µg/ mL). The antibacterial activity against S. aureus strains was observed in EtOAc (MIC 256-512 µg/mL), which showed a very low toxicity. The chemical study of this fraction revealed the abundant presence of polyphenolic compounds. The antibacterial and antioxidant activities reported in this paper for EtOAc extract from B. sartorum and the low toxicity of this fraction opens the possibility that it could be helpful for the developing of new antibacterial agents for treating S. aureus infections.

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Section: Discussionmentioning

confidence: 99%

Antibacterial and antioxidant activities and acute toxicity of Bumelia sartorum Mart., Sapotaceae, a Brazilian medicinal plant

Ruela¹,

Leal²,

Almeida³

et al. 2011

Rev. bras. farmacogn.

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“…Doenças de Pele e do Tecido Celular Subcutâneo (DPTCS) estiveram relacionadas com a espécie Ziziphus joazeiro sendo a mais utilizada para caspa e tratamento capilar. Cartaxo et al, (2010) subcutâneo (Cruz et al, 2007;Alviano et al, 2008) o que corrobora com a utilização popular desta espécie. Transtorno do Sistema Sensorial Ouvidos (TSS(OU)), teve a Ruta graveolens como sendo a espécie principal na categoria, apresentando doze citações para dor no ouvido, seguida do Ocimum basilicum L. que apresentou cinco citações, para tratamento desta enfermidade; nas duas espécies são utilizadas o sumo das folhas aplicados diretamente no ouvido.…”

Section: Concordância De Uso Das Espécies Medicinaisunclassified

Potencial terapêutico e uso de plantas medicinais em uma área de Caatinga no estado do Ceará, nordeste do Brasil

Ribeiro

Macêdo

Oliveira

et al. 2014

Rev. bras. plantas med.

127

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RESUMO:O presente trabalho visou o levantamento etnobotânico das plantas medicinais, verificando a versatilidade das espécies utilizadas e o consenso de uso e/ou conhecimento entre os informantes, do Distrito de Aratama, no Município de Assaré, Ceará. As informações etnobotânicas foram obtidas através de entrevistas estruturadas e semi-estruturadas com os moradores locais. Foram citadas 116 espécies com fins medicinais pertencentes a 103 gêneros e 58 famílias com destaque para Fabaceae (10ssp.), Asteraceae (7spp.) e Lamiaceae (6spp.). Entre as espécies levantadas, Mentha spicata L., Rosmarinus officinalis L., Allium sativum L., Bauhinia cheilantha (Bong.), Ximenea americana L., se destacaram como as mais versáteis dentro da comunidade. As indicações terapêuticas citadas foram agrupadas em 16 categorias de sistemas corporais, dos quais as Desordens mentais e comportamentais, as Afecções ou dores não definidas, os Transtornos do sistema respiratório, as Doenças de pele e do tecido celular subcutâneo, e os Transtornos do sistema sensorial (ouvidos), mostram maior concordância entre os informantes na utilização de espécies para tratar um sistema corporal especifico. Os resultados mostraram elevada riqueza da flora medicinal presente na caatinga. Neste sentido, torna-se necessária a intensificação de estudos que avaliem e consolidem as propriedades químicas e farmacológicas destas espécies.Palavras-chave: Etnobotânica, semiárido, Importância Relativa, Fator Consenso de Informantes.ABSTRACT: Therapeutic potential and use of medicinal plants in an area of the Caatinga in the state of Ceará, northeastern Brazil. This study is about an ethnobotanical survey of medicinal plants, checking the versatility of the species used and the consensus of use and/or knowledge among informants from the Aratama District, in the municipality of Assaré, state of Ceará, Brazil. The ethnobotanical information was obtained through structured interviews and semi-structured interviews with local residents. Approximately, 116 species were mentioned for medicinal purposes, belonging to 103 genera and 58 families, especially Fabaceae (10ssp.), Asteraceae (7spp.) and Lamiaceae (6spp.). Among the surveyed species, Mentha spicata L., Rosmarinus officinalis L., Allium sativum L. and Bauhinia cheilantha (Bong.) Ximenea americana L. stood out as the most versatile in the community. The therapeutic indications mentioned were grouped into 16 categories of body systems; the mental and behavioral disorders, disorders or pain not defined, disorder of the respiratory system, skin diseases and subcutaneous tissue disorder, and disorder of the sensory system (ears) showed greater agreement among informants in the use of species to treat a specific body system. The results showed a high species richness of the medicinal flora present in the Brazilian Caatinga. Thus, it is necessary to intensify and consolidate studies assessing the chemical and pharmacological properties of these species.

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“…28,29 The method of extract preparation and the part of the plant used are also crucial to unlock the potential of bioactive constituents of studied plant species. 26,30 Differences as to the production method of extracts were also evidenced between the studies. In this study, we used maceration, and in the study by Cruz et al, 26 decoction was used.…”

Section: Jcdpmentioning

confidence: 99%

Antimicrobial Potential of Plant Extracts and Chemical Fractions of Sideroxylon obtusifolium (Roem. & Schult.) T.D. Penn on Oral Microorganisms

Sampaio¹,

Cartaxo-Furtado²,

Medeiros³

et al. 2017

The Journal of Contemporary Dental Practice

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Aim:The aim of this study is to evaluate the in vitro antimicrobial activity of plant extracts and chemical fractions of Sideroxylon obtusifolium T.D. Penn on Streptococcus mutans, Streptococcus oralis, Streptococcus salivarius, Streptococcus parasanguinis, and Candida albicans as well as to identify the chemical classes found in the bioactive extracts possessing better activity. Materials and methods:Freeze-dried hydroalcoholic extracts of the bark and leaves (LC and LF respectively) and ethanol extracts of bark and leaves (EC and EF respectively) of S. obtusifolium were assessed for antimicrobial potential by determining the minimum inhibitory concentration (MIC), minimum bactericidal concentration, and minimum fungicidal concentration (MFC). The tests were performed by microdilution method (in triplicate) in three independent experiments. Phytochemical characterization was performed by quantification of total polyphenols, total flavonoids, and condensed tannins. Results:The EC extract presented weak antimicrobial potential on the growth of S. mutans (MIC = 1000 µg/mL); all extracts showed moderate inhibitory activity on the growth of C. albicans (MIC = 500 µg/mL). The dichloromethane and n-butanol fractions of LF extracts showed moderate growth inhibitory activity (MIC = 250 µg/mL) on C. albicans and fungicide potential (MFC/MIC = 2). The phytochemical characterization revealed a Conclusion:The dichloromethane and n-butanol fractions of S. obtusifolium LF extract showed antifungal activity against C. albicans, with the potential for bioprospection of phytocompounds for the treatment of periodontal fungal diseases caused by this microorganism. The effect may be related to phytochemical compounds from the polyphenol and condensed tannin classes.Clinical significance: Research for new oral microbial disease treatment alternatives in bioactive compounds from medicinal plants is of clinical relevance and scientific interest since many therapeutic antifungal agents do not obtain the effectiveness expected due to microbial resistance, or to adverse effects on human tissues.

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In vitro antioxidant potential of medicinal plant extracts and their activities against oral bacteria based on Brazilian folk medicine

Cited by 115 publications

References 32 publications

Antibacterial and antioxidant activities and acute toxicity of Bumelia sartorum Mart., Sapotaceae, a Brazilian medicinal plant

Antibacterial and antioxidant activities and acute toxicity of Bumelia sartorum Mart., Sapotaceae, a Brazilian medicinal plant

Potencial terapêutico e uso de plantas medicinais em uma área de Caatinga no estado do Ceará, nordeste do Brasil

Antimicrobial Potential of Plant Extracts and Chemical Fractions of Sideroxylon obtusifolium (Roem. & Schult.) T.D. Penn on Oral Microorganisms

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