In vitro antioxidant, anticholinesterase, tyrosinase activity studies, and LC-MS/MS simultaneous determination of 37 bioactive compounds in Indigofera heterantha

Ullah, Zafar; Ali, Saqib; Hussain, Atarad; Öztürk, Mehmet; Ertaş, Abdülselam; Alamzeb, Muhammad; Rashid, Mehboob ur; Ullah, Hamid; Zaman, Rubia; Imtiaz, Muhammad

doi:10.1016/j.sajb.2022.05.012

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Considering all the above-mentioned evidence, and following the multi-targeting molecules strategy [ 22 ], we propose that compounds with antioxidant and/or anti-inflammatory properties could enhance the effort for obtaining more effective treatment options for AD [ 23 ]. With this aim, we designed and synthesized a series of heterocyclic compounds by amidation of ethyl piperidine-3-carboxylate (ethyl nipecotate) with various carboxylic acids.…”

Section: Introductionmentioning

confidence: 99%

Nipecotic Acid Derivatives as Potent Agents against Neurodegeneration: A Preliminary Study

2022

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Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by memory loss and cognitive impairment. Its pathology has not been fully clarified and therefore highly effective treatments have not been obtained yet. Almost all the current treatment options aim to alleviate only the symptoms and not to eliminate the disease itself. Acetylcholinesterase inhibitors are the main therapeutic agents against AD, whereas oxidative stress and inflammation have been found to be of great significance for the development and progression of neurodegeneration. In this work, ethyl nipecotate (ethyl-piperidine-3-carboxylate), a heterocyclic carboxylic acid derivative, which acts as a GABA reuptake inhibitor and has been used in research for diseases involving GABAergic neurotransmission dysfunction, was amidated with various carboxylic acids bearing antioxidant and/or anti-inflammatory properties (e.g., ferulic acid, sinapic acid, butylated hydroxycinnamic acid). Most of our compounds have significant antioxidant potency as lipid peroxidation inhibitors (IC50 as low as 20 μΜ), as oxidative protein glycation inhibitors (inhibition up to 57%), and act as DPPH reducing agents. Moreover, our compounds are moderate LOX inhibitors (up to 33% at 100 μΜ) and could reduce rat paw edema induced by carrageenan by up to 61%. Finally, some of them possessed inhibitory activity against acetylcholinesterase (IC50 as low as to 47 μΜ). Our results indicate that our compounds could have the potentiality for further optimization as multi-targeting agents directed against AD.

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Section: Introductionmentioning

confidence: 99%

Nipecotic Acid Derivatives as Potent Agents against Neurodegeneration: A Preliminary Study

2022

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“…There are some hypotheses about the formation of Alzheimer's disease, but the exact reason is unclear. The lack of acetylcholine in the brain is the only known hypothesis [40]. Therefore, acetylcholinesterase inhibitory drugs have been developed and used for the patients.…”

Section: Anticholinesterase Inhibitory Activitymentioning

confidence: 99%

Determination of Fatty Acids Profile, Antioxidant, and Anticholinesterase Inhibitory Activities of Ganoderma lucidum collected from Swat, Pakistan

Ullah¹,

Ibrarullah²,

Shad³

et al. 2022

Rec. Agric. Food. Chem

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The current study was conducted on methanol extract of Ganoderma lucidum to evaluate its antioxidant, enzyme inhibition activities, and fatty acids profile. The dominant fatty acids were found to be linoleic acid (53.6 %), oleic acid (24.2 %), and palmitic acid (11.5 %) among the 10 different fatty acids detected in the methanol extract using GC/MS techniques. Fatty acids groups like C14:0, C15:0, C16:1, C17:0, C17:1, C18:0, and C18:3 were also found from trace to middle amount (0.15 %, 0.15 %, 1.11 %, 0.26 %, 0.27 %, 2.85 %, and 5.9 %) respectively. Polyunsaturated fatty acids concentration of G. lucidum exposed the significance for lowering the blood cholesterol level. Methanol extract of G. lucidum showed significant antioxidant potential against β-carotene-linoleic acid assay (IC50: 687.12 ± 2.8 µg/mL), metal chelating activity (IC50: 870.00 ± 10.05 µg/mL), and CUPRAC reducing potential (A0.5: 16.55 ± 4.53 µg/mL) respectively. The CUPRAC assay supports the lipid peroxidation inhibitory activity results. Against AChE enzyme, methanol extract of G. lucidum demonstrated IC50 value 19.11 ± 2.4 µg/mL, while exhibited weak butyrylcholinesterase (BChE) inhibitory activity (IC50 > 100 μg/mL). Thus, Ganoderma lucidum may defend people in contradiction of free radical damage, and may be an important source of potential new acetylcholinesterase (AChE) inhibitory drugs.

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Effect of Maillard conjugates of peptides and polydextrose on Antarctic krill oil emulsion stability and digestibility

Cui

Wang

Han

et al. 2023

LWT

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In vitro antioxidant, anticholinesterase, tyrosinase activity studies, and LC-MS/MS simultaneous determination of 37 bioactive compounds in Indigofera heterantha

Cited by 5 publications

References 30 publications

Nipecotic Acid Derivatives as Potent Agents against Neurodegeneration: A Preliminary Study

Nipecotic Acid Derivatives as Potent Agents against Neurodegeneration: A Preliminary Study

Determination of Fatty Acids Profile, Antioxidant, and Anticholinesterase Inhibitory Activities of Ganoderma lucidum collected from Swat, Pakistan

Effect of Maillard conjugates of peptides and polydextrose on Antarctic krill oil emulsion stability and digestibility

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