In vitro antioxidant, anti-diabetic and antilipemic potentials of quercetagetin extracted from marigold (Tagetes erecta L.) inflorescence residues

Wang, Weiyou; Xu, Huaide; Chen, Hua; Tai, Kedong; Liu, Fuguo; Gao, Yanxiang

doi:10.1007/s13197-016-2228-6

Cited by 57 publications

(48 citation statements)

References 36 publications

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“…Herbacetin has been described to have anti‐hyperglycaemic and anti‐hyperlipidemic properties (Veeramani et al , ). Quercetagetin exhibited strong in vitro antioxidant, anti‐diabetic and antilipidemic activities, having potential application for the treatment of obesity and diabetes (Wang et al , ).…”

Section: Discussionmentioning

confidence: 99%

Production of flavonoid and lignan aglycones from flaxseed and soy extracts by Bifidobacterium strains

Peirotén

Álvarez

Landete

2019

Int J of Food Sci Tech

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Flaxseed and soybean are an important source of phytochemical compounds, mainly lignans and isoflavones, but also of flavones, flavanones and flavonols. These compounds appear mainly glycosylated in plant food and are converted into aglycones by the intestinal microbiota, increasing their bioavailability. In this work, we analyse the ability of Bifidobacterium strains (n = 25) to produce lignan and flavonoids aglycones from flaxseed and soybean extracts. Most of the Bifidobacterium strains increased the concentrations of secoisolariciresinol, daidzein, genistein, naringenin, eriodyctiol, luteolin and apigenin. Moreover, Bifidobacterium pseudocatenulatum and Bifidobacterium breve strains showed high production of herbacetin, increased the kaempferol concentration and produced quercetin and quercetagetin. B. pseudocatenulatum INIA P815 and B. breve INIA P367 produced 32.37 AE 2.81 and 28.64 AE 3.36 mg respectively of herbacetin g À1 of lignan extract. Bifidobacterium strains transformed the glycosides of a wide range of flavonoids into their aglycones, increasing the antioxidant activity and improving their bioavailability. Metabolism of flavonoids by bifidobacteria A. Peirot en et al. 2123 102.6 AE 57.6 139.4 AE 32.4 141.5 AE 21.7 B. pseudocatenulatum INIA P846 152.8 AE 22.1 158.4 AE 12.0 168.2 AE 18.8 B. pseudocatenulatum INIA P946 204.2 AE 35.3 154.8 AE 6.4 195.7 AE 11.1 B. pseudolongum INIA P2 13.6 AE 4.4 65.4 AE 2.3 73.2 AE 15.2 B. pseudolongum INIA P120 16.8 AE 7.5 46.7 AE 2.6 69.5 AE 11.7 B. pseudolongum INIA P977 15.8 AE 4.4 62.1 AE 16.9 101.6 AE 8.0 Metabolism of flavonoids by bifidobacteria A. Peirot en et al. †Units are expressed as equivalents of Trolox or Gallic acid expressed as mg mL À1 of fermentation media. Metabolism of flavonoids by bifidobacteriaA. Peirot en et al.

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Section: Discussionmentioning

confidence: 99%

Production of flavonoid and lignan aglycones from flaxseed and soy extracts by Bifidobacterium strains

Peirotén

Álvarez

Landete

2019

Int J of Food Sci Tech

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“…Literature reported that aglycones have better antioxidant and anti‐inflammatory effects than diglycosides (Yang et al ., ). It was also reported that quercetin exhibits greater antioxidant activity than rutin, and therefore, it has potential benefits to treat diabetes and obesity (Wang et al ., ). The production of antioxidants by removing rhamnose from rutin was reported in literature (Cruz‐Zúñiga et al ., ).…”

Section: Resultsmentioning

confidence: 97%

Production of high antioxidant activity flavonoid monoglucosides from citrus flavanone with immobilised α‐L‐rhamnosidase in one step

Liu

Huang

Leng

et al. 2019

Int J of Food Sci Tech

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Summary The rhamnosyl group of naringin dihydrochalcone, neohesperidin dihydrochalcone, naringin and hesperidin was selectively removed by enzymatic hydrolysis using an immobilised α‐L‐rhamnosidase. Monoglycosylated products, including trilobatin, hesperetin dihydrochalcone‐7‐O‐glucoside, prunin and hesperetin‐7‐O‐glucoside, were isolated and characterised by 1H and 13C NMR and ESI‐MS. To optimise the enzymatic reaction conditions and its process costs, the hydrolysis of neohesperidin dihydrochalcone to produce trilobatin was selected as a model reaction. Using a ratio of neohesperidin dihydrochalcone: immobilised α‐L‐rhamnosidase equal to 1:0.6, the trilobatin yields was over 98%. The recycle of enzyme was also investigated, obtaining trilobatin with a yields of 80% even when the twentieth reaction cycle was conducted. Moreover, antiradical and antimicrobial activities of the obtained flavonoid monoglucosides were examined by DPPH, FRAP and ORAC methods, and compared with the efficacy of parental flavonoid glycosides and their aglycone. The results highlight that some of the obtained flavonoid monoglucosides show significant improvement in the antioxidant activity.

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“…However, pancreatic islet cells of diabetic rats treated with C. lobatus leaf methanol extracts appear normal. This suggests an inhibition of the toxic mechanisms involved in the alloxan-induced, oxidative stress-mediated destruction of pancreatic Islet cells by the antioxidant rich, flavonoid-containing C. lobatus extract inducing increased antioxidant enzyme activity, and consequently preserving Islet cells integrity [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic and antioxidant effects of Croton lobatus l. in alloxan-induced diabetic rats

Fasola¹,

Ukwenya²,

Oyagbemi³

et al. 2016

J Intercult Ethnopharmacol

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Background:Croton lobatus contains a high amount of antioxidant phytochemicals that probably account for its wide use as food and medicine in the traditional communities of West Africa.Methods:The study evaluated the modulatory role of methanol extract of Croton lobatus leaf on alloxan-induced diabetes and associated cardiovascular complications. Male rats were randomly selected and assigned to one of six groups (A to F) of eight animals each: A (distilled water); B (corn oil); C (Alloxan); D (Alloxan + 100 mg kg-1 Croton lobatus); E: (Alloxan + 200 mg kg-1 C. lobatus); and F (Alloxan + 100 mg kg-1 glibenclamide).Results:Acute toxicity studies revealed no mortality of rats at the administration of different doses of extract up to the 5,000 mg kg-1 dose. Histology of the pancreas showed focal area of necrosis, and fatty infiltration in diabetic untreated rats, but these lesions were absent in pancreas of rats treated with C. lobatus extract.Conclusion:Methanol leaf extract of C. lobatus reduced arteriogenic risk factors, improved antioxidant status, restored the observable pathological lesions associated with experimental diabetes in rats, and thus offers a new therapeutic window as herbal therapy for the treatment of diabetes mellitus and associated cardiovascular complications.

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In vitro antioxidant, anti-diabetic and antilipemic potentials of quercetagetin extracted from marigold (Tagetes erecta L.) inflorescence residues

Cited by 57 publications

References 36 publications

Production of flavonoid and lignan aglycones from flaxseed and soy extracts by Bifidobacterium strains

Production of flavonoid and lignan aglycones from flaxseed and soy extracts by Bifidobacterium strains

Production of high antioxidant activity flavonoid monoglucosides from citrus flavanone with immobilised α‐L‐rhamnosidase in one step

Antidiabetic and antioxidant effects of Croton lobatus l. in alloxan-induced diabetic rats

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