Antidiabetic and antioxidant effects of Croton lobatus l. in alloxan-induced diabetic rats

Abstract

Background:Croton lobatus contains a high amount of antioxidant phytochemicals that probably account for its wide use as food and medicine in the traditional communities of West Africa.Methods:The study evaluated the modulatory role of methanol extract of Croton lobatus leaf on alloxan-induced diabetes and associated cardiovascular complications. Male rats were randomly selected and assigned to one of six groups (A to F) of eight animals each: A (distilled water); B (corn oil); C (Alloxan); D (Alloxan + 100 mg kg-1 Croton lobatus); E: (Alloxan + 200 mg kg-1 C. lobatus); and F (Alloxan + 100 mg kg-1 glibenclamide).Results:Acute toxicity studies revealed no mortality of rats at the administration of different doses of extract up to the 5,000 mg kg-1 dose. Histology of the pancreas showed focal area of necrosis, and fatty infiltration in diabetic untreated rats, but these lesions were absent in pancreas of rats treated with C. lobatus extract.Conclusion:Methanol leaf extract of C. lobatus reduced arteriogenic risk factors, improved antioxidant status, restored the observable pathological lesions associated with experimental diabetes in rats, and thus offers a new therapeutic window as herbal therapy for the treatment of diabetes mellitus and associated cardiovascular complications.

<i>Astraea lobata</i> (L) Klotzsch (Euphorbiaceae): An ethnopharmacological review

“…Histology of the pancreas showed focal area of necrosis and fatty infiltration in diabetic untreated rats, but these lesions were absent in pancreas of rats treated with A. lobata extract. Methanol leaf extract of A. lobata reduced arteriogenic risk factors, improved antioxidant status, restored the observable pathological lesions associated with experimental diabetes in rats [37].…”

“…A number of biological activities of A. lobata have been reported in literature which may be used to explain some of the medicinal applications of the species. Such biological activities include antibacterial [36], antidiabetic [37], antiplasmodial [9,38,39], antioxidant [27,36], antitrypanosomal [9], leishmanicidal [9], cytotoxicity and toxicity [12,36,39] activities.…”

“…The ameliorative effects of A. lobata on alloxaninduced diabetes and associated cardiovascular derangements were evaluated by Fasola et al [37] by assessing the effects of the leaf extract on blood glucose level, blood pressure changes, electrocardiographic (ECG) abnormalities, lipid profile, and anti-oxidant status of alloxan-induced diabetic rats. Acute toxicity studies revealed no mortality of rats at the administration of different doses of extract up to the 5,000 mg/kg dose.…”

Phytochemical Management of Diabetic Complications, Experimental Evidences

“…lobatus is an erect, annual, herbaceous plant, often harvested for local use as food and medicine. An investigation of the modulatory role of the methanol extract of C. lobatus leaf on alloxan-induced diabetes and associated cardiovascular complications revealed reduced arteriogenic risk factors, improved antioxidant status, and improvement in observable pathological lesions associated with experimental diabetes in rats [13].…”

Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of &lt;i&gt;P. americana&lt;/i&gt; Leaf in Alloxan-Induced Diabetic Rats

“…The increasing incidence of the disease worldwide may be due to sedentary life style, unhealthy diet, obesity and other predisposing risk factors [1,2]. Complications of diabetes mellitus include hypertension, atherosclerosis and microcirculatory disorder [3], retinopathy, nephropathy, and foot ulceration [4]. It is projected by 2040 to become of the world's main disablers and killers, as the number of people with diabetes multiplies worldwide [5].…”