In vitro antioxidant activity of acetylated and benzoylated derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta)

Qi, Huimin; Zhang, Quanbin; Zhao, Tingting; Hu, Rugui; Zhang, Kun; Li, Zhien

doi:10.1016/j.bmcl.2006.01.076

Cited by 232 publications

(126 citation statements)

References 26 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…The superoxide anion-scavenging activity was measured following the method of Qi et al (2006). Briefly, 1 ml of various concentrations of sample was mixed with 1 ml of 0.1 M phosphate buffer (pH 7.4) containing 150 μM NBT, 60 μM PMS and 468 μM NADH.…”

Section: Superoxide Anion Scavenging Assaymentioning

confidence: 99%

Alkali extraction and in vitro antioxidant activity of Monascus mycelium polysaccharides

et al. 2012

View full text Add to dashboard Cite

In the present work, alkali extraction technology was used to optimize the extraction of Monascus mycelium polysaccharides for the first time. The extracting parameters of alkali extracted Monascus mycelium polysaccharides were optimized by Box-Behnken design (BBD). The optimum conditions were extraction temperature 49°C, alkali concentration 7%, solvent/material ratio 23:1 (ml/g) and extraction time 2.3 h with an enhanced yield of 10.1%, compared with the yield 4.76% of hot water extraction, indicating that alkali extraction is a more efficient way. In order to discuss the biological activity of alkali extracted polysaccharides, we compared the in vitro antioxidant activity of alkali extracted polysaccharides (AMP) with hot water extracted polysaccharides (HMP). The result showed that AMP have the similar capability of scavenging both superoxide radical and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical of HMP in vitro. Therefore, alkali extraction technology is not only a highefficiency way to extract AMP, but also can retain the natural antioxidant activities of AMP, which can be used in pharmaceutical and food industries.

show abstract

Section: Superoxide Anion Scavenging Assaymentioning

confidence: 99%

Alkali extraction and in vitro antioxidant activity of Monascus mycelium polysaccharides

et al. 2012

View full text Add to dashboard Cite

show abstract

“…These reductions may be due to the increased utilization of these anti-oxidants for quenching free radicals produced during HC-HG condition. In parallel results, Qi et al [56] found that atorvastatin and glibenclamide treatment to HC-HG rats enhanced the concentration of liver GSH and attributed this to the ability of drugs to improve the defensive nature of liver against free radicals which in turn preserved liver and pancreas architectures. Thus, the same could be applicable to I. tricolor and S. tomentosa extracts which in turn ameliorate liver and pancreas architectures.…”

Section: The Hepatic Ameliorative Effect Of I Tricolor and S Tomentosamentioning

confidence: 82%

Statistical Data Analysis Which Result From the Bio-Diagnosis and Bio-Treatment of Injured Rats With the Hyperlipidemia and Hyperglycemia Diseases

Abduallah¹,

Abd‐Alla²,

Ali³

et al. 2016

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: This study in bioinformatics aims to investigate the potential effect of Ipomoea tricolor and Sophora tomentosa on liver function enzymes activity, serum lipid profile, oxidative stress biomarkers, and on blood glucose in high fat diet-induced hypercholesterolemia (HC) and STZ-induced hyperglycemia (HG) in rats.Methods: Blood glucose level, liver function enzymes, alanine aminotransferases and aspartate aminotransferases, alkaline phosphatase, and lactate dehydrogenase (LDH) were determined. Besides, lipid profile including total cholesterol (TC), triacylglycerol (TG), total lipid, and high-density lipoprotein-cholesterol was investigated. Moreover, oxidative stress biomarkers, lipid peroxide, and nitric oxide as well as non-enzymatic antioxidant, glutathione (GSH) were also examined in different therapeutic groups.Results: A significant increase in blood glucose level, liver function enzyme activities, LDH, lipid profile and oxidative stress markers, while significant decrease in LDH-C and GSH level in HC-HG induced rats compared to control one. A marked amelioration in all biochemical parameters under investigation on treatment of HC-HG rats with I. tricolor and S. tomentosa with different fluctuating percentages of improvement. Histopathological examination of liver and pancreas was also performed and declared HC-HG showed congestion in portal vessels and sinusoids with mild centrilobular hepatocyte degeneration, marked hepatocyte ballooning and hydropic degeneration, while HC-HG treated rats with I. tricolor and S. tomentosa showed normal lobular hepatic architecture with mild sinusoidal dilatation and congestion. On the other hand, a histological organization of pancreas of HC-HG rats showing disarrangement changes in pancreatic blood vessels and interlobular duct as well as disordered in acini. The treatment of HC-HG rats with I. tricolor and S. tomentosa showed enhancement in Langerhans cells and restore of most pancreatic tissue in comparison with standard drugs. Conclusion:The statistical results showed that each extract ameliorated high blood glucose level liver injury, HC and oxidative stress indicating relieving of oxidative damage associated with the complexity of HG and HC. These results demonstrated that these two plants extracts may be a candidate intelligent antioxidant, hypolipidemic, hypoglycemic, and hepatoprotective nutraceuticals which need further clinical investigation to be applied effectively to reduce perturbation in HC associated diabetes.

show abstract

“…However, L-ascorbic acid loses its activity at higher concentrations, which may reduce its benefits when used as a food supplement and/or antioxidant drug. Zhang et al (2010) showed that acetylated polysaccharides with high donating-hydrogen abilities showed excellent reducing power, and in sulfated polysaccharides, the presence of the sulfate groups lead to the diminution of hydroxyl groups, which resulted in the descent of the reducing power, which may explain the lower SPSG reducing power activity compared to vitamin C. However, this SPSG activity was higher than the sulfated polysaccharide from green algae reported in the literature, the Ulvan, a sulfated polysaccharide purified from Ulva lactuta (Qi et al, 2006). It has been previously reported that there was a direct correlation between antioxidant activities and reducing power of polysaccharide.…”

Section: Discussionmentioning

confidence: 94%

Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii

Silva¹,

Dantas-Santos²,

Gomes³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Abstract:A sulfated polysaccharide (SPSG) was successfully isolated from seagrass Halodule wrightii Asch., Cymodoceaceae, and its antioxidant and anticoagulant activities were investigated. The data presented here showed that the SPSG is a 11 kDa sulfated heterogalactan with a sulfatation degree of 20.63% and it also contains glucose and xylose. SPSG antioxidant activities were evaluated using several in vitro assays and the anticoagulant activity was evaluated by aPTT and PT tests. These assays suggested that the SPSG possessed remarkable antioxidant properties in different in vitro assays and an outstanding anticoagulant activity 2.5-fold higher than that of heparin Clexane ® in the aPTT test. This data represents the first reported on the sulfated polysaccharide biological activities from seagrass. These results indicate that SPSG can be considered in the future as a drug utilized in treating diseases from these systems.

show abstract

In vitro antioxidant activity of acetylated and benzoylated derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta)

Cited by 232 publications

References 26 publications

Alkali extraction and in vitro antioxidant activity of Monascus mycelium polysaccharides

Alkali extraction and in vitro antioxidant activity of Monascus mycelium polysaccharides

Statistical Data Analysis Which Result From the Bio-Diagnosis and Bio-Treatment of Injured Rats With the Hyperlipidemia and Hyperglycemia Diseases

Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii

Contact Info

Product

Resources

About