In vitro Antioxidant Activity of Porana paniculata and Ipomoea quamoclit-Two Ethnomedicinally Important Plants of Convolvulaceae Family

Kumar, Amith; Reddy, J. Pranay; Gupta, V. Rama Mohan

doi:10.9734/bjpr/2015/12226

Cited by 4 publications

(6 citation statements)

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“…The IC 50 value of 68.4 µg/ml obtained from the DPPH method indicates the effectiveness of the plant extract in scavenging DPPH radicals [26] . Another study on the ME of a whole I. quamoclit plant powder revealed the presence of various phytoconstituents, including saponins, phenolic compounds, alkaloids, carbohydrates, tannins, phytosterols, flavonoids, and amino acids [27] .…”

Section: Discussionmentioning

confidence: 99%

Phytochemical and antioxidant potential of the crude extracts of Ipomoea quamoclit

Sultana¹,

Sarker²

2023

J. Med. Plants Stud.

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The emergence of new chronic and infectious diseases has spurred intense research efforts to identify new and effective substances for combating these global health challenges. Plants have been widely acknowledged as a principal source of drug discovery due to their remarkable ability to produce a diverse array of bioactive molecules. Thus, this study aimed to investigate the phytochemical and antioxidant potential of the crude extracts obtained from different parts of Ipomoea quamoclit. Various parts of I. quamoclit were collected, ground, dried, and processed into a coarse powder. Subsequently, solvent extraction using methanol and ethyl acetate was performed to obtain the extracts. The methanolic extract (ME) of the plant's leaves exhibited a higher phenolic content (6.097±0.189 mg/g of GAE) compared to the ME of the root (4.515±0.1884 mg/g of GAE). Additionally, the ethyl acetate extract (EAE) of the leaves showed a higher flavonoid content (12.815±0.234 mg/g of CAE) compared to the EAE of the root (11.229±3.558 mg/g of CAE). Moreover, the ME of the stem displayed a higher antioxidant capacity (41.488±0.684 mg/g of AAE) than the ME of the leaves (37.133±5.604 mg/g of AAE). The DPPH radical scavenging activity of the ME of the stem of I. quamoclit was 64.050%, comparable to that of BHT (77.48%). These findings indicate that I. quamoclit holds promise as a valuable source of phytochemicals and antioxidant compounds.

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Section: Discussionmentioning

confidence: 99%

Phytochemical and antioxidant potential of the crude extracts of Ipomoea quamoclit

Sultana¹,

Sarker²

2023

J. Med. Plants Stud.

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“…As a chronic inflammatory autoimmune disease, rheumatoid arthritis is closely related to oxidative stress ( Peng et al, 2021 ). The 60% ethanol extract (extract 4 ) of P. paniculata presented good anti-oxidant activity in DPPH assay, superoxide anion scavenging activity assay, nitric oxide scavenging activity assay, hydrogen peroxide scavenging assay and metal chelating activity ( Kumar et al, 2015 ). In the superoxide anion scavenging assay, extract 4 exhibited more robust activity than the positive control butylated hydroxyanisole.…”

Section: Pharmacological Activities Of Porana Plantsmentioning

confidence: 99%

“…Porana paniculata Roxb. has been used in folk medicine to treat pain and inflammation in Ayurveda and India ( Kumar et al, 2015 ). Porana sinensis Hemsl.…”

Section: Introductionmentioning

confidence: 99%

The genus Porana (Convolvulaceae) - A phytochemical and pharmacological review

Peng

Li²,

Yang³

et al. 2022

Front. Pharmacol.

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There are about 20 species of Porana Burm. f. worldwide in tropical and subtropical Asia, Africa and neighboring islands, Oceania, and the Americas. In China, India, and other places, this genus enjoys a wealth of experience in folk applications. Nevertheless, the chemical composition of only five species has been reported, and 59 compounds have been isolated and identified, including steroids, coumarins, flavonoids, quinic acid derivatives, and amides. Pharmacological studies revealed that extracts from this genus and their bioactive components exhibit anti-inflammatory, analgesic, antioxidant, anti-gout, anti-cancer, and anti-diabetic effects. Although this genus is abundant, the development of its pharmacological applications remains limited. This review will systematically summarize the traditional and current uses, chemical compositions, and pharmacological activities of various Porana species. Network analysis was introduced to compare and confirm its output with current research progress to explore the potential targets and pathways of chemical components in this genus. We hope to increase understanding of this genus’s medicinal value and suggest directions for rational medicinal development.

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“…[26][27][28][29] Herbal medicines as a therapeutic tool have been used for centuries to treat different illnesses and numerous medicinal plants and their derivatives are used as the inflammatory diseases treatment. [30][31][32][33][34] Much research has been undertaken to identify the active compounds and mechanisms of action of plants used in traditional medicine. 30 Bougainvillea x buttiana is one of genera of the Nyctaginaceae family widely used in Mexico traditional medicine.…”

Section: Introductionmentioning

confidence: 99%

“…We previously showed the immunomodulatory effect of the ethanolic extract of Bougainvillea x buttiana on peritoneal macrophages. 33 Thus, the aim of this study was to expand understanding of the antiinflammatory activity of ethanolic extract from B. xbuttiana in macrophages, J774A.1 stimulated by LPS. Their effects on immune related nitric oxide and cytokines production (TNF-α, IL-1β and IL-6), and phagocytic activity were investigated.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of Ethanolic Extract of Bougainvillea x buttiana on LPS-induced J774A.1 macrophages

Petricevich,

Cortezano

2023

PPIJ

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Introduction: Bougainvillea is used in Mexico to treat of various disorders. It is largely used in folk medicine as an infusion to gastrointestinal and respiratory disorders to treat cough, asthma, bronchitis and as laxative. To know the direct activity of this plant species on immune system cells the present study evaluated the immunostimulant activities of ethanolic extract from Bougainvillea x buttiana (Orange) (BxbOE) in murine macrophage cell line J774A.1.Methods: BxbOE extract was tested on J774A.1 cells to prove their immune-stimulant effect as determines by the viability, phagocytic index and mediators production. Methylthiazolydiphenyltetrazolium bromide (MTT) and Griess assays were performed to evaluate cell viability and nitric oxide (NO) production, respectively. The phagocytic activity was determined by non-opsonized zymosan was addition and the amount of engulfed zymosan. While the cytokines levels were tested by enzyme-linked immunosorbent assay (ELISA) method. Results:Concentrations of BxbOE at 200 to 400 μg/mL had cytotoxicity on J774A.1 cells LPS-stimulated, however, while in cells treated with lower concentrations (from 0.01 to 100 μg/mL) did not produce significant cytotoxic effects and not exhibited an inhibitory effect phagocytic index. Our results showed that the BxbOE can inhibit the pro-inflammatory mediators production including nitric oxide and cytokines comprising IL-1β, TNF-α and IL-6, and an increment of IL-10 levels. Conclusion:Our results help to aggregate for literature data on the immunostimulation activity of this plant species, cell from the immune system involved in the innate and acquired immune response, the macrophages.

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In vitro Antioxidant Activity of Porana paniculata and Ipomoea quamoclit-Two Ethnomedicinally Important Plants of Convolvulaceae Family

Cited by 4 publications

References 0 publications

Phytochemical and antioxidant potential of the crude extracts of Ipomoea quamoclit

Phytochemical and antioxidant potential of the crude extracts of Ipomoea quamoclit

The genus Porana (Convolvulaceae) - A phytochemical and pharmacological review

Anti-inflammatory effect of Ethanolic Extract of Bougainvillea x buttiana on LPS-induced J774A.1 macrophages

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