In vitro antioxidant activities and HPTLC analysis of ethanolic extract of Cayratia trifolia (L.)

Palanisamy, Chella Perumal; Sophia, Dominic; Raj, Chinthamony Arul; Ragavendran, Paramasivam; Starlin, Thangarajan; Gopalakrishnan, Vishrawas

doi:10.1016/s2222-1808(12)60299-0

Cited by 26 publications

(21 citation statements)

References 22 publications

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“…MP9 showed high ABTS scavenging potential but its DPPH scavenging potential was found to be low than other medicinal plants analysed. MP8, MP12 and MP2 were reported for high antioxidant activity (Nilip and Gouri, 2013;Perumal et al, 2012;Tharakan et al, 2005). Antioxidant and antiproliferative properties on human hepatoma cells of Vitex sps.…”

Section: Resultsmentioning

confidence: 99%

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Screening of ethnic medicinal plants of South India against influenza (H1N1) and their antioxidant activity

John

Enkhtaivan

Ayyanar³

et al. 2015

Saudi Journal of Biological Sciences

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Antiviral activity against H1N1 influenza was studied using ethnic medicinal plants of South India. Results revealed that Wrightia tinctoria (2.25 μg/ml) was one of the best antidotes against H1N1 virus in terms of inhibitory concentration of 50% (IC50) whereas the control drug Oseltamivir showed 6.44 μg/ml. Strychnos minor, Diotacanthus albiflorus and Cayratia pedata showed low cytotoxicity (>100) to the MDCK (Malin darby canine kidney) cells by cytotoxicity concentration of 50% (CC50) and possessed antiviral activity suggesting that these plants can be used as herbal capsules for H1N1 virus. W. tinctoria and S. minor showed high therapeutic indexes (TI) such as 12.67 and 21.97 suggesting that those plants can be used for anti-viral drug development. The CC50 values of Eugenia singampattiana (0.3 μg/ml), Vitex altissima (42 μg/ml), Salacia oblonga (7.32 μg/ml) and Salacia reticulata (7.36 μg/ml) resulted in cytotoxicity of the MDCK cells, due to their high phenolic content. Findings from this study state that the plant W. tinctoria can be a potent source for third generation anti-viral drug development against H1N1.

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Section: Resultsmentioning

confidence: 99%

“…and Trichopus sps. were reported for their antioxidant activity and metabolic content by Nilip and Gouri, (2013), Perumal et al, (2012), Tharakan et al, (2005). Duraipandiyan et al, (2006), Ponnusamy et al (2011) studied the antimicrobial properties of Diotacanthus sps.…”

Section: Introductionmentioning

confidence: 99%

Screening of ethnic medicinal plants of South India against influenza (H1N1) and their antioxidant activity

John

Enkhtaivan

Ayyanar³

et al. 2015

Saudi Journal of Biological Sciences

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“…Alkaloids are used as anaesthetic agents and are found in medicinal plants. 11 Variety of bioactive compounds is present in medicinal plants and they are widely used against various diseases. The demand for natural food constituents has resulted in broad research on naturally occurring bioactive compounds which are able to develop novel drug agents for many diseases.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Novel C-X-C Chemokine Receptor Type 4 (CXCR4) Inhibitors from Hexane Extract of Euclea crispa (Thunb.) Leaves by Chemical Fingerprint Identification and Molecular Docking Analysis

Palanisamy¹,

Ashafa²

2018

JYP

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Objectives: To evaluate the potential inhibitors aginst CXCR4 from hexane extract of Euclea crispa (E. crispa) leaves. Methods: The natural compounds were identified and charecterized through GC-MS Analysis. Molecular docking studies carried out to investigatethe inhibitory activity angainst CXCR4. Absorption, Distribution, Metabolism, and Excretion (ADME) properties also were predicted to find pharmacokinetics and pharmacodynamics of compounds.Results:The molecular docking simulations revealed that, Benzoic acid 3-methyl-4-(1,3,3,3-tetrafluoro-2-methoxycarbonyl-propenylsulfanyl)-phenyl ester (SCHEMBL15979821), Hydrocortisone Acetate and Phenyl Glucuronide possess good inhibitory activites (Glide Score of -7.06, -6.97, -6.47 and Glide Energy of -43.22, -48.27 and -32.80 kcal/mol respectively) when compared with standard FDA approved drug and other compounds. All the screened compounds were within the acceptable and permissible limits of ADME properties. Conclusion: Thus, from this study it can be concluded that, these screened natural compounds from E. crispa leaves may serve as potential inhibitors for CXCR4 and they might lead to development of new therapeutic agents against cancer and its associated complications.Key words: E.crispa, GC-MS analysis, CXCR4, Molecular docking, ADME properties. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. Correspondence

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“…Berdasarkan hasil penelitian melalui dua pengujian, diperoleh nilai IC50 sebesar 0.48 μg/ml untuk metode DPPH dan 1.36 μg/ml untuk metode peroksidasi lipid [18]. Sedangkan ekstrak etanol C. trifolia memiliki nilai IC50 77 berdasarkan pengujian menggunakan metode penangkal radikal nitrit oksida [30].…”

Section: Antioksidanunclassified

Galing (Cayratia trifolia L.): Sebuah Kajian Biologi, Fitokimia, dan Aktivitas Farmakologi

Feriadi¹,

Muhtadi²,

Barliana³

2019

Pharmauho

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Galing (Cayratia trifolia L.) merupakan salah satu tumbuhan liar yang mayoritas terdapat di Asia Tenggara, termasuk Indonesia. Galing secara empiris telah banyak digunakan untuk mengobati berbagai macam penyakit. Hampir semua bagian dari tumbuhan galing dapat dimanfaatkan sebagai obat tradisional. Beberapa penelitian telah dilakukan untuk membuktikan aktivitas farmakologis dari tumbuhan galing. Oleh karena itu, tinjauan ini bertujuan untuk menyajikan informasi mengenai tumbuhan galing, baik secara biologi, fitokimia maupun aktivitas farmakologisnya.Kata kunci: Herbal, galing, Cayratia trifolia, obat tradisional, farmakologi

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In vitro antioxidant activities and HPTLC analysis of ethanolic extract of Cayratia trifolia (L.)

Cited by 26 publications

References 22 publications

Screening of ethnic medicinal plants of South India against influenza (H1N1) and their antioxidant activity

Screening of ethnic medicinal plants of South India against influenza (H1N1) and their antioxidant activity

Analysis of Novel C-X-C Chemokine Receptor Type 4 (CXCR4) Inhibitors from Hexane Extract of Euclea crispa (Thunb.) Leaves by Chemical Fingerprint Identification and Molecular Docking Analysis

Galing (Cayratia trifolia L.): Sebuah Kajian Biologi, Fitokimia, dan Aktivitas Farmakologi

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