In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids

Rauscher, R.; Edenharder, R.; Platt, Karl L.

doi:10.1016/s1383-5718(98)00017-5

Cited by 112 publications

(64 citation statements)

References 41 publications

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“…To some extents, it is therefore, logical to say that there is a direct relationship between phenolic contents, antioxidant and antimutagenic activities. This is in line with the opinions of some investigators who previously used Ames test to evaluate mutagenicity and antimutagenicity of plant extracts and fruit juices (Zahin et al, 2010;Schneider et al, 1997;Cherdshewasart et al, 2008;Ham et al, 2009;Karekar et al, 2000;Oh et al, 2008;Rauscher et al, 1998;Son et al, 2003). In the other of FDFJ except M. fragrans, induction of negative percentage reduction of CP-induced CA or total arrest of cell division by the mixture of the FDFJ and CP at certain concentrations may be due to prooxidative activity of phenoilc compounds, causing generation of ROS to cause more DNA damages.…”

Section: Effects Of the Fdfj On A Cepa Chromosomessupporting

confidence: 85%

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

Akinboro¹,

Mohamed²,

Asmawi³

et al. 2011

Afr. J. Biotechnol.

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Mutagenic and antimutagenic activities of freeze dried fruit juices (FDFJ) ofTesting the mutagenic activity, onions were suspended in solution of different concentrations of FDFJ alone in tap water for 48 h. Thereafter, root tips were prepared and observed for dividing cells and chromosomal aberrations using a light microscope. Antimutagenicity screening was similar to the mutagenic evaluation, except that the solution of FDFJ was combined with 0.1% cylophosphamide-CP. Free radicals (2,2-diphenyl-1-picrylhyrazyl) scavenging activity of the FDFJ was tested using butylated hydroxylanisole (BHA) and butylated hydroxytoluene (BHT) as the standards and their phenolic contents were evaluated by comparing with gallic acid equivalents (GAE). The free radicals scavenging power of M. fragrans at 1 mg/ml was almost similar to that of BHA and BHT and its phenolic content was 21 ± 6.0 mg GAE/g, the highest among the tested juices. A. cepa cell division was inhibited in a dose-dependent manner by the FDFJ of M. fragrans, while the induced chromosomal aberrations were non dose dependent. The cytotoxicity and chromosomal aberrations of CP were suppressed throughout the tested concentrations of M. fragrans, unlike the effects of other four juices. These results suggest that the observed activities of FDFJ of M. fragrans may be due to the quantity and quality of phenolic compounds with antioxidant activity, suggesting its use in preventing the DNAdamaging effects of mutagens.

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Section: Effects Of the Fdfj On A Cepa Chromosomessupporting

confidence: 85%

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

Akinboro¹,

Mohamed²,

Asmawi³

et al. 2011

Afr. J. Biotechnol.

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“…Carotenoids have many properties that may be important in the prevention of carcinogenesis, antioxidation having been the primary focus in many studies. Recent research found that carotenoids have other pertinent properties, including antimutagenic and anticlastogenic effects (Rauscher et al, 1998), inhibitory effects on Epstein-Barr virus activation activity of a tumour promoter (Tsushima et al, 1995), and cytoprotective effects (Javor et al, 1983). Multivariate RRs include age (continuous), duration of smoking (continuous), smoking dose (continuous), total energy (quintiles), and trial intervention (alpha-tocopherol and beta-carotene supplementation).…”

Section: Epidemiologymentioning

confidence: 99%

Intakes of fruits and vegetables, carotenoids and vitamins A, E, C in relation to the risk of bladder cancer in the ATBC cohort study

Pietinen²,

et al. 2002

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We examined the relation between dietary fruit and vegetables, carotenoids and vitamin intakes and the risk of bladder cancer among male smokers in a prospective cohort study. Over a median of 11 years, we followed 27 111 male smokers aged 50 -69 years who were initially enrolled in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study. During this period, 344 men developed bladder cancer. All of these men had completed a 276-food item dietary questionnaire at baseline. Cox proportional hazards models were used to estimate the relative risks and 95% confidence intervals and to simultaneously adjust for age, smoking history, energy intake and intervention group. Consumption of fruits and vegetables was not associated with the risk of bladder cancer (relative risk=1.28; 95% confidence intervals CI: 0.89 -1.84, for highest vs lowest quintile). Similarly, no associations were observed for groups of fruits or vegetables (berries and cruciferous vegetables), or for specific fruits and vegetables. Dietary intakes of alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin, beta-cryptoxanthin, vitamins A, E, and C, and folate were not related to the risk of bladder cancer. These findings suggest that fruit and vegetable intakes are not likely to be associated with bladder cancer risk. However, these results may not be generalisable to nonsmokers.

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“…There is increasing interest in the identification of herbal and dietary compounds that can prevent or reduce the risks of cancer or serve as therapeutic agents (Rauscher et al, 1998;Li et al, 2000). One result of these efforts is that chemoprevention has emerged as a cost-effective means of preventing mutagenesis and carcinogenesis, and as a promising approach for minimizing the adverse effects of human exposure to environmental carcinogens (PoolZobel et al, 1997;Rauscher et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…One result of these efforts is that chemoprevention has emerged as a cost-effective means of preventing mutagenesis and carcinogenesis, and as a promising approach for minimizing the adverse effects of human exposure to environmental carcinogens (PoolZobel et al, 1997;Rauscher et al, 1998). Doxorubicin (DOX), a broad-spectrum anthracycline antibiotic, is genotoxic and carcinogenic but is still widely used as an antitumor agent for the treatment of cancer (Minotti et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Protection by Panax ginseng C.A. Meyer against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster

et al. 2008

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Panax ginseng is one of the most widely prescribed herbal medicines for the treatment of cancer, diabetes, chronic inflammation, and neurodegenerative and cardiovascular diseases. Since the use of alternative medicines in combination with conventional therapy may increase the risk of unwanted interactions, we investigated the possible genotoxicity of a water-soluble form of the dry root of P. ginseng (2.5, 5.0 or 10.0 mg/mL) and its ability to protect against the genotoxicity of doxorubicin (DOX; 0.125 mg/mL) by using the Drosophila melanogaster wing somatic mutation and recombination test (SMART) with standard and high-bioactivation crosses of flies. Panax ginseng was not genotoxic at the concentrations tested, whereas DOX-induced genotoxicity in marker-heterozygous flies resulted mainly from mitotic recombination. At low concentrations, P. ginseng had antirecombinogenic activity that was independent of the concentration of extract used. Recombination events may promote cancer, but little is known about the ability of P. ginseng to inhibit such recombination or modulate DNA repair mechanisms.

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In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids

Cited by 112 publications

References 41 publications

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

Intakes of fruits and vegetables, carotenoids and vitamins A, E, C in relation to the risk of bladder cancer in the ATBC cohort study

Protection by Panax ginseng C.A. Meyer against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster

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