In vitro antifungal potentials of bioactive compound oleic acid, 3-(octadecyloxy) propyl ester isolated from Lepidagathis cristata Willd. (Acanthaceae) inflorescence

Abubacker, M. N.; Devi, Palaniyappan Kamala

doi:10.12980/apjtb.4.201414b189

Cited by 16 publications

(9 citation statements)

References 5 publications

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“…The electron-donating ability of the investigated extracts was measured by bleaching a purple solution of 1,1diphenyl-2-picrylhydrazyl (DPPH) radical according to the method of Sermakkani and Thangapandian [22]. Aliquot of 0.1 ml extract (20,40,60,80, 100 μg/ml) was added to 3.9 ml of 36 mg/l DPPH-methanol solution.…”

Section: Dpph Radical Scavenging Activitymentioning

confidence: 99%

Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts

Diab

Donia

Saad‐Allah

2021

Beni-Suef Univ J Basic Appl Sci

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Background Natural products from plants are very safe as compared to synthetic ones, so the aim of this study was to assess the in vitro antioxidant and antitumor activities of the ethanolic extracts of four Egyptian wild plant species (Varthemia candicans, Peganum harmala, Suaeda vermiculata, and Conyza dioscoridis), as well as polyphenols and flavonoid contents with gas chromatography–mass spectrometry (GC-MS). The antioxidant activity of the four plant extracts was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) to determine 50% inhibition of DPPH radical scavenging activity and reducing power by phosphomolybdate assay. In addition, the chemical composition of the four sample extracts was investigated using GC-MS. The total phenolic and flavonoid levels were also determined. Then, the antitumor activity of the plant extracts against HepG2 cells was determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results The results showed that Varthemia candicans extract was the highest one regarding both polyphenols and flavonoid contents. Moreover, the extract of Suaeda vermiculata exhibited the lowest half maximum inhibitory concentration (IC50) against DPPH, thus indicating its highest effectiveness. All studied plant extracts decreased the viability of HepG2 cells, in a dose- and time-dependent manner, and the lowest IC50 was for Suaeda vermiculata. Conclusion The investigated plant extracts showed potent antioxidant and antitumor activities in vitro due to their phytochemical contents.

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Section: Dpph Radical Scavenging Activitymentioning

confidence: 99%

Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts

Diab

Donia

Saad‐Allah

2021

Beni-Suef Univ J Basic Appl Sci

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“…Leaf extract was also used in cleaning the cattle in rainy season. Recent research on L. cristata extracts showed the presence of alkaloids, glycosides, oleic acid which supports to the therapeutic effects believed in traditional medicine (Reddy et al, 2013;Ravikanth et al, 2001;Abudacker et al, 2014;Purma et al, 2013;Teeguarden et al, 2007). Leaf extract of L. cristata having bio molecules can act as reducing and capping agent and are responsible for the synthesis of Ag NPs.…”

Section: Introductionmentioning

confidence: 62%

Competitive rapid microwave-assisted biogenic synthesis of spherical silver nanoparticles using an aqueous leaf extract of Lepidagathis cristata: Characterization and antimicrobial studies

2018

J App Pharm Sci

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In the present study, microwave assisted biogenic synthesis of silver nanoparticles (Ag NPs) was carried out by using aqueous leaf extract of Lepidagathis cristata (L. cristata) which can act itself as a reducing and capping agent. This method was very precious due to their economic and eco-friendly benefits. The microwave assisted biogenic synthesized Ag NPs were characterized and analyzed by various instruments such as ultraviolet-visible spectroscopy (UV-vis), fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) coupled with X-ray energy dispersive spectroscopy (EDS). The UV-vis absorption spectrum peak at 430 nm, corresponds to the characteristic peak of Ag NPs. The functional biomolecules present in the L. cristata were identified by FT-IR spectroscopy, the XRD analysis explored that the synthesized Ag NPs have high crystallinity, face-centered cubic structure, and spherical shape. Ag NPs properties like size and stability (Zeta potential) of the NPs were calculated by Nano Particle Size Analyzer (NPSA). Further, we evaluated the antibacterial activity of the Ag NPs. The microwave assisted biogenic synthesized Ag NPs to show an excellent antibacterial activity against bacteria's like Escherichia coli, Pseudomonas aeruginosa (Gram −Ve bacteria), Streptococcus pneumonia (gram +Ve bacteria) and the zone of inhibition range was determined.

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“…Phenol, 2, 4-bis (1, 1-dimethylethyl) (13.41) was reported to possess antifungal, antimicrobial, antimalarial, UV stabilizer and an antioxidant for hydrocarbon-based products [20]. The compound 3,7,11,15-tetramethyl-2-hexadecen-1-ol (17.08) was reported to have antimicrobial, anticancer, anti-inflammatory, anti-diuretic [21], Pentatriacontene (20.05) an herbistat [22], Eicosane, 9-octyl-(22.74) with anticancer activity [23], Octadecane, 3-ethyl-5-(2-ethylbutyl (25.97) was reported to possess In vitro antifungal activity [24]. The details were given in table 4.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Studies and Gc-MS Analysis of Spermadictyon Suaveolens Roxb

Papitha

Ravi

Selvaraj

2017

Int J Pharm Pharm Sci

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Objective: The present study was performed to identify the phytochemical constituents of leaves and flowers of a plant Spermadictyon suaveolens extracted with four different solvents.Methods: Dried and powdered samples were subjected to soxhlation based on the polarity of the solvents. The extracts were scanned using Ultra Violet-visible (UV-Vis) spectrophotometry with the wavelength ranging from 200-800 nm by comparing the absorption spectrum with the spectra of known compounds, Fourier Transform Infrared (FT-IR) spectrometry was used to find out the functional groups of the compounds and GC-MS system consisting of a Perkin Elmer Technologies Model Clarus 680 GC equipped with Clarus 600 (EI) was used to identify the metabolites by matching their recorded mass spectra with the standard mass spectra from National Institute of Standards and Technology (NIST05. LIB) libraries provided by the software of the GCMS system (Turbo Mass version 5.4.2). Results:The phytochemical tests indicated the presence of carbohydrates, alkaloids, flavonoids, phenols, tannins, saponins and terpenoids from the chloroform extract of leaves and flowers. UV-visible spectrophotometer results indicated a wavelength range between 230-660 nm for the flower and leaf extracts for major peaks. FT-IR analysis indicated major functional groups such as aromatic, primary, secondary and aliphatic amines, alkanes, carboxylic acids and amides. GC-MS analysis results revealed major bioactive compounds in the crude extracts. Conclusion:Presence of secondary metabolites has been identified from the phytochemical studies. Many phyto-compounds have been identified from the leaves and flowers of using GC-MS analysis. Hence, this medicinal plant may be used as a source for treating many diseases.

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In vitro antifungal potentials of bioactive compound oleic acid, 3-(octadecyloxy) propyl ester isolated from Lepidagathis cristata Willd. (Acanthaceae) inflorescence

Cited by 16 publications

References 5 publications

Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts

Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts

Competitive rapid microwave-assisted biogenic synthesis of spherical silver nanoparticles using an aqueous leaf extract of Lepidagathis cristata: Characterization and antimicrobial studies

Phytochemical Studies and Gc-MS Analysis of Spermadictyon Suaveolens Roxb

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