Furthermore, the antioxidant properties of several antidiabetic functional foods, as well as their alpha-amylase and alpha-glucosidase inhibitory potential, have been reported, and it has been shown that the majority of these foods are important in the management/treatment of type 2 diabetes. 5-10 However, the bioactive components in these functional meals responsible for their anti-diabetic properties are yet to be identified. These bioactive substances can halt starch absorption, hence preventing postprandial hyperglycemia in type 2 diabetes mellitus. The general application of Curcuma longa, commonly known as Turmeric includes spice in curries (food additive), natural dyes, cosmetics, the rhizome of turmeric is used as a valuable cash crop, 11 and traditional medicine. It has been found to possess countless therapeutic activities ranging from an anti-inflammatory, anti-diabetic, antioxidant, anti-hepatotoxic, anti-microbial, anti-depressant to the more recent chemo-preventive, anti-fertility, neuroprotective, HIV-1 and HIV-2 protease inhibitor. 12 It has a long history of traditional use dating back around 4000 years to the Vedic culture in India. During this time, it was utilized both as a culinary spice in Indian cuisine and as a remedy for various ailments. These included enhancing digestion and promoting a healthy intestinal environment, relieving gas and eliminating intestinal worms, supporting liver health, reducing swelling, for local application on sprains, burns, cuts, bruises, insect bites, and itching, for soothing action in cough and asthma and addressing weakness when used internally and externally. 13 Therefore, in this research, we present a unique contribution by using both in vitro enzyme inhibition assays and in silico simulation to