In vitro Antidiabetic Effect of Saponins and Phenolic Extracts from Fruits and Seeds of Algerian Cypress Tree: Cupressus sempervirens L

Boussoussa, Hadjer; Khacheba, Ihcen; Berramdane, Tayeb; Maamri, Anfal; Bendahgane, Hanya; Yousfi, Mohamed

doi:10.2174/1573408014666180115153812

Cited by 8 publications

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“…The results reflect that the plant studied above can act as a very good alternative in the field of medicine based on antioxidant property of natural products chemistry. As reported by Boussoussa et al [42], the phenol and saponins extracts for both seeds and cones inhibited enzymatic activity of α-amylase under in vitro starch digestion bioassay with the IC50 values ranged from 0.49 to 1.12 mg/ml. In the previous study, methanol extracts at 100 μg/ml exhibited α-amylase inhibitory potential of 36.3 ± 0.6 % in comparison to standard drug, acarbose with 62.4 ± 0.4 % [45].…”

Section: Discussionsupporting

confidence: 55%

“…The antioxidant potential of Ageratina adenophora, Cupressus sempervirens, and Lantana camara has been evaluated by various previous studies [39][40][41][42][43][44]. The IC50 values of methanol extract of Lantana camara (106.179 ± 11.390 µg/ml) was much lesser than the quantity (165 µg/ml) as reported by Swamy et al [33] from the methanol extract of Lantana camara collected from the tropical region of Malaysia.…”

Section: Discussionmentioning

confidence: 93%

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Estimation of phytochemicals, antioxidant, antidiabetic and brine shrimp lethality activities of some medicinal plants growing in Nepal

Kapali

Sharma

2021

J. Med. Plants

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Background: Extreme production of free radicals in the human body causes direct damage to biological molecules that leads to the different types of diseases. The natural or synthetic antioxidants inhibit directly the production or restrict propagation or nullify the free radicals produced in the human body to protect the immune system. Objective: This study aims to quantify the total phenolic and flavonoid content, antioxidant and antidiabetic activities and toxicity test for the methanol extracts of aerial parts of traditionally used medicinal plants like Ageratina adenophora (Spreng.) R.M.King & H.Rob., Cupressus sempervirens L. and Lantana camara L. Methods: The total phenolic content (TPC) was estimated by Folin-Ciocalteu reagent method and the total flavonoid content (TFC) by aluminum chloride assay. The α-amylase inhibition activity was performed to evaluate the antidiabetic activities of plant extracts. Results: Lantana camara showed the highest phenol content (10.20 ± 0.343 mg gallic acid equivalent /g extract) and flavonoid content (1.87 ± 0.160 mg quercetin equivalent /g extract) among the three plant samples, respectively. The methanol extracts of Lantana camara showed the strongest DPPH radical scavenging activity with IC50 of 106.18 ± 11.390 µg/ml. In addition, Ageratina adenophora methanol extract was found to inhibit α-amylase activity with IC50 value of 1.84 ± 0.007 mg/ml. The methanol extract of Ageratina adenophora was found to be toxic against brine shrimp with median lethal concentration (LC50) value of 833.68 µg/ml. Conclusion: This research shows that the traditionally used medicinal plants are the rich and potent sources of natural antioxidant and antidiabetic compounds which may be the potent natural drug candidates in the future drug discovery process.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 93%

Estimation of phytochemicals, antioxidant, antidiabetic and brine shrimp lethality activities of some medicinal plants growing in Nepal

Kapali

Sharma

2021

J. Med. Plants

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“…This is done by inhibiting the enzymes involved in carbohydrate hydrolysis, such as α‐amylase. The latter decomposes the starch into disaccharides and oligosaccharides, before intestinal α‐glucosidase catalyzes the degradation of disaccharides into glucose, which is then absorbed into the bloodstream (Boussoussa et al., 2018). Several inhibitors of α‐amylase, including acarbose, voglibose, and miglitol are oral agents, clinically used for treatment.…”

Section: Resultsmentioning

confidence: 99%

In vitro antioxidant and α‐amylase inhibitory potential of methanolic and lipid fractions fromPistacia atlantica Desf. galls

Hefied

Ahmed

Yousfi

2020

J. Food Process. Preserv.

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The aim of this study is to evaluate the effects of harvest period, growing region, and shapes of P. atlantica galls on the chemical composition, as well as on the antioxidant activities and ability to inhibit the carbohydrate hydrolyzing enzymes. Thus, the fatty acid composition; the determination of total sterols and tocopherols; the quantitative analysis of phenolic compounds; the antioxidant activities (DPPH • , FRAP, and ABTS •+) and the α-amylase inhibitory activity were carried out. Two shapes (spherical and semi-circular) of galls collected at different harvest periods were used in this work. The result revealed that all the methanolic, lipid extracts, and unsaponifiable fractions showed antioxidant and α-amylase inhibitory activities. Notably, the methanolic extracts from spherical galls has a higher antioxidant activity than those from semi-circular galls. Whereas, in lipid extracts, the observation is reversed. A higher α-amylase inhibitory activity for semi-circular galls was recorded in August and in September for spherical galls. Practical applications Galls are used in traditional medicine. Results from the present study suggest that galls are a good source of natural antioxidants and potential alternatives to control postprandial hyperglycemia. They can be useful for developing nutraceuticals, functional foods, and additives in food processing for health. This is the first report of α-amylase inhibitory activity for methanolic and lipid extracts from P. atlantica galls. How to cite this article: Hefied F, Ben Ahmed Z, Yousfi M. In vitro antioxidant and α-amylase inhibitory potential of methanolic and lipid fractions from Pistacia atlantica Desf.

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“…The aerial parts of the plant are used in folk medicine as astringent, incorporated in preparations (ointments and suppositories) and used to treat haemorrhoids, varicose veins and venous circulation disorders. The Antidiabetic activity of saponins and phenolic extracts of the cones and seeds from C. sempervirens was reported by Boussoussa et al (2018). The essential oil is used as antiseptic and antispasmodic for stubborn coughs (Rawat et al, 2010) and possesses antimicrobial, antioxidant and anticancer properties (Mothana et al, 2009;Elansary et al, 2012;Fayed, 2015), while the extracts possess antimicrobial and antibiofilm properties, and therefore, can be used as natural preservative ingredients in food and/or pharmaceuticals (Gomez-Estaca et al, 2010; Romeo et al, 2010;Selim et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

In vitro production of some secondary metabolites from Cupressus sempervirens.

Alhady

El-Fadl

Hegazi

et al. 2020

Journal of advanced Biomedical and Pharmaceutical Sciences

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Cupressus sempervirens L. has known medicinal activities, which are related to the presence of miscellaneous secondary metabolites, involved in patents for pharmaceuticals and/or cosmetics in the market. The aim of this study is to perform a comparative investigation of the main metabolites in the wild, cultivated and callus cultures of C. sempervirens using different treatments and the in vitro production of certain metabolites from C. sempervirens callus cultures in concentrations adequate for use commercially and also to develop a convenient chromatographic method for both the qualitative and quantitative determination of the most beneficial flavonoids (rutin and quercitrin), along with other metabolites (ferruginol, 2-furancarboxaldehyde,5 methyl, pentadecanoic acid, totarol, quinic acid and hinokiol) using HPLC/DAD and GC/MS, respectively. Leaf extract of the wild plant induced reduction in cell viability of some tested cell lines as: human hepatocellular carcinoma cell (HEPG2), lung carcinoma cell (A549), human Caucasian breast adenocarcinoma (MCF7) and especially on human colon cancer cell (HCT116), which was higher than doxorubicin used as a standard. This study is a stepping stone for obtaining natural and renewable bioactive secondary metabolites from C. sempervirens through in vitro callus cultures.

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In vitro Antidiabetic Effect of Saponins and Phenolic Extracts from Fruits and Seeds of Algerian Cypress Tree: Cupressus sempervirens L

Cited by 8 publications

References 0 publications

Estimation of phytochemicals, antioxidant, antidiabetic and brine shrimp lethality activities of some medicinal plants growing in Nepal

Estimation of phytochemicals, antioxidant, antidiabetic and brine shrimp lethality activities of some medicinal plants growing in Nepal

In vitro antioxidant and α‐amylase inhibitory potential of methanolic and lipid fractions fromPistacia atlantica Desf. galls

In vitro production of some secondary metabolites from Cupressus sempervirens.

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