In vitro anticandidal and antioxidant potential of Mezoneuron benthamianum

Fayemi, Scott; Osho, A.; Atolanı, Olubunmi

doi:10.1016/s2221-6189(13)60028-1

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…The potential of M. benthamianus as a strong antioxidant agent could be attested to by previous reports. Fayemi et al, 2012 [18], reported the DPPH antioxidant activity of the ethanolic extract of M.benthamianum with IC 50 of 781.5 μg/mL, while [17] reported the DPPH antioxidant activity of the petroleum ether and chloroform extracts of M. benthamianum with IC 50 of 15.33 and 19.72 μg/mL. These values are comparable to those obtained in our study as MBE and MBAM had the highest antioxidant activities with IC 50 of 23.70 and 21.30 μg/mL, even higher than that of standard ascorbic acid (38.20 μg/mL).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of Mezoneuron benthamianum root extracts on oral cariogenic microorganisms and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging radical

et al. 2020

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Background: Chewing sticks are commonly used as oral hygiene tool in Africa and reactive oxygen species have been linked to the cause of degenerative diseases because of their ability to induce oxidative damage to biological molecules. Plants have been a long source of dietary antioxidants as most plants have been found to exhibit excellent antioxidant potentials. Mezoneuron benthamianum is a plant that is used locally as chewing sticks in southwest, Nigeria, but its use as a therapeutic agent in dental caries, a disease caused by bacteria especially Streptococcus mutans is poorly investigated. This study was therefore designed to investigate the anticaries activities of the crude extracts of M. benthamianum root against four clinical oral pathogens (Staphylococccus aureus, Escherichia coli, Pseudomonas aeruginosa and Streptococcus mutans) and the antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Results: The results of this study showed that M. benthamianum had a consistent activity against all the bacterial organisms tested, with the ethyl acetate extract having the highest anticaries activity with minimum inhibitory concentration values of 78 and 156 μg/mL, while the hexane extract had the least anticaries activity with MIC values of 2500 μg/ml against S. mutans and E. coli respectively. The results also revealed that the ethyl acetate and aqueous methanol extract exhibited a higher antioxidant activity (IC 50 = 23.70 and 21.30 μg/mL) than standard ascorbic acid (IC 50 = 38.20 μg/mL). Conclusion: This study demonstrated the anticaries and antioxidant potentials of M.benthamianum and therefore justifies the folkloric use of M. benthamianum in oral hygiene.

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Section: Discussionmentioning

confidence: 99%