In vitro antibacterial effects of topical local anesthetics

Göçmen, Jülide Sedef; Büyükkoçak, Ünase; Çağlayan, Osman; Aksoy, Altan

doi:10.1080/09546630802050498

Cited by 19 publications

(17 citation statements)

References 9 publications

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“…When the studies in the literature are analysed, it can be seen that LAs have a wide antimicrobial effect spectrum, yet P. aeruginosa is resistant to LAs . In line with the literature, it was detected in our study that prilocaine and bupivacaine did not have an antimicrobial effect on P. aeruginosa .…”

Section: Discussionsupporting

confidence: 89%

“…In the study by Rosenberg et al, it was reported that bupivacaine did not have an antimicrobial effect on P. aeruginosa . In addition, in the study by Gocmen et al, it was reported that the prilocaine/lidocaine combination did not have antimicrobial effect on P. aeruginosa . Consonant to the results of this study, it was detected in our study that neither bupivacaine nor prilocaine had an antimicrobial effect on P. aeruginosa .…”

Section: Discussionmentioning

confidence: 93%

“…Wound infections adversely affect wound healing. This leads to increased treatment costs, morbidity, and mortality . Bupivacaine is also used as an epidural infusion for postoperative pain management and labour analgesia .…”

Section: Discussionmentioning

confidence: 99%

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Bacterial inhibition efficiency of prilocaine and bupivacaine

Kesi̇ci̇¹,

Demırci

Kesici

2019

International Wound Journal

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This study aimed to demonstrate the antibacterial effects of bupivacaine and prilocaine on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. In our study, the in vitro antimicrobial effects of 20 mg/mL prilocaine and 5 mg/mL bupivacaine were tested against a S. aureus American‐type culture collection (ATCC) 29213, P. aeruginosa ATCC 27853, and E. coli ATCC 25922, divided into Group P (Prilocaine) and Group B (Bupivacaine), respectively. S. aureus ATCC 29213, P. aeruginosa ATCC 27853, and E. coli ATCC 25922 were cultured on Mueller Hinton agar (Oxoid, Basingstoke, UK) plates for 18 to 24 hours at 37°C. In terms of inhibition zone diameters, inhibition of S. aureus ATCC 29213 was observed in both groups at the 12th and 24th hours. The 12th‐ and 24th‐hour S. aureus ATCC 29213 value was significantly higher in Group P compared with Group B (P = .008). At the 12th and 24th hours, inhibition of E. coli ATCC 25922 was observed in both groups. The 12th‐ and 24th‐hour E. coli ATCC 25922 value was significantly higher in Group P compared with Group B (P = .008). In our study, it was seen that prilocaine and bupivacaine had an antimicrobial effect on S. aureus and E. coli. In the comparison between these two local anesthetics (LAs), this effect was found to be significantly higher in prilocaine than bupivacaine. Therefore, we are of the opinion that antimicrobial effect potentials should also be taken into account in the selection of an LA agent in order to prevent the complications of an infection that might develop during LA infiltration and might lead to serious morbidity.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 93%

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Bacterial inhibition efficiency of prilocaine and bupivacaine

Kesi̇ci̇¹,

Demırci

Kesici

2019

International Wound Journal

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“…In this present study, MIC values of lidocaine for S aureus and E coli were found to be 20 and 5 mg. respectively; and these values were found to decrease to 10 and 2.5 mg when lidocaine and adrenaline were administered in combination. A study by Sedef et al determined that mupirocine demonstrated antimicrobial effects on E coli , P aeruginosa , and S aureus but these effects were not demonstrated on P aeruginosa . Our present study results are consistent with these previously reported results in the latter study.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial effects of local anaesthetics

Kesici

Demırci

Kesi̇ci̇

2019

International Wound Journal

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After the introduction of cocaine to the medical practice, local anaesthetics (LA) became essential in pain control. LA infiltration along the incision may be used to provide surgical anaesthesia or postoperative analgesia. This study aimed to compare the antimicrobial effects of the topical antimicrobial agent mupirocine with those of the LA lidocaine and the combination of lidocaine and adrenalin. In our study, the in vitro antimicrobial effects of 1 mL sterile saline, 20 mg/mL mupirocine, 20 mg/mL Lidocaine, and 20 mg/mL Lidocaine and Adrenaline were tested against Staphylococcus aureus American type culture collection (ATCC) 29213, Pseudomonas aeruginosa ATCC 27853, and Escherichia coli ATCC 25922 as Group C (Control), Group M (Mupirocine), Group L (Lidocaine), and Group LA (Lidocaine + adrenaline), respectively. S aureus ATCC 29213, P aeruginosa ATCC 27853, and E coli ATCC 25922 were cultured onto Mueller–Hinton agar (Oxoid, UK) plates for 18 to 24 hours at 37°C. Colonies from these plates were suspended in sterile saline and a 0.5 McFarland turbidity standard suspension (corresponding to 1.5 × 108 CFU/mL) of each isolate was prepared. S Aureus ATCC 29213 inhibition zone diameter values of Group M, Group LA, and Group L were significantly higher compared with the group C (P ˂ 0.05). P aeruginosa ATCC 27853 inhibition zone diameter values of Group M and Group LA were significantly higher compared with the group C (P ˂ 0.05). E coli ATCC 25922 inhibition zone diameter values of Group M, Group LA, and Group L were significantly higher compared to the group C (P ˂ 0.05). LA infiltration along the incision may be used to provide surgical anaesthesia or postoperative analgesia. Considering that LAs show antimicrobial effects besides their analgesic effects, they may contribute to preventing the development and reducing the rate of surgical infections, decreasing the requirement to administer antibiotics. However, caution should be exercised not to antagonise the effective treatment of surgical infections, remembering that controversy on the antimicrobial effects of LAs remains in the literature. Therefore, further comprehensive studies with larger patient populations are warranted to demonstrate the antimicrobial effects of LAs.

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“…Previous research emphasized the antibacterial properties of bupivacaine [42][43][44] . Controversy surrounds lidocaine antibacterial properties though there are studies in the literature emphasizing its antibacterial properties 45 . However, bacterial strains are not inhibited up to 2 hours after 1% lidocaine administration and when biopsy cultures are required within two hours, lidocaine should be used 46 .…”

Section: Discussionmentioning

confidence: 99%