In vitro antibacterial activity of Peganum harmala (L) extract to some fish pathogenic bacteria

Akbary, Paria; Fereidouni, Mohammad Saeid; Akhlaghi, Mostafa

doi:10.18869/acadpub.ijaah.1.1.7

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…[ [84][85][86][87][88][89][90] Anti-proliferative effects a. Some triterpenoids isolated from P. harmala exhibited potent anti-proliferative activities.…”

Section: Discussionmentioning

confidence: 99%

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

2021

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Background Medicinal plants are potential source of natural products that play an important role in preventing different human diseases. P. harmala is used traditionally as emmenagogue and an abortifacient agent in the Middle East, North of Africa and West of China. It belongs to the family of Zygophyllaceae and it is a wild growing flowering plant. Its seeds are main medicinal part of the plant. Methods The current searching was done by the keywords in main indexing systems including PubMed/MEDLINE, Scopus, and Institute for Scientific Information Web of Science as well as the search engine of Google Scholar. The keywords were wild rue, traditional medicine, Harman, health benefits, and pharmaceutical science. Results The most important uses of P. harmala in traditional pharmaceutical sciences are in cardiovascular, gasterointestinal, nervous, endocrine, neoplasm and tumors, pain relieving, organisms, diabetes, respiratory, disinfectant, anti-pyretic, skin and hair, rheumatism, arthritis and inflammation, and ulcers. Pharmacological effects of P. harmala are in cardiovascular system, nervous system, antimicrobial effects, antineoplasm, nervous system, endocrine, gastrointestinal effects, osteocytes, endocrine and respiratory system. Phenolic compounds are the main reason of antioxidant capacity. Conclusions Due to its pharmacological activities, P. harmala is a high potential medicinal herb and the suggestion is to increases by doing research in efficacy and safety.

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“…[ [84][85][86][87][88][89][90] Anti-proliferative effects a. Some triterpenoids isolated from P. harmala exhibited potent anti-proliferative activities.…”

Section: Discussionmentioning

confidence: 99%

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

2021

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“…Studies on the chemical compositions of P. harmala have suggested that the leaves of this plant are comprised of various components, particularly alkaloids and flavonoids (14,15,24). It has also been explored that P. harmala leaf extracts benefit from antioxidant (25), antibacterial (26,27), and cytotoxic (28) activities due to polyphenol compositions. Considering the effective role of alkaloids and flavonoids in the inhibition of apoptosis (19)(20)(21)(22)(23) and very scant investigations of the anti-apoptotic properties of P. harmala, the current research was undertaken to evaluate the anti-apoptotic effect of the leaf extract of P. harmala, based on its alkaloids and flavonoids, in type 2 diabetic model rats.…”

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confidence: 99%

Assessment of the Anti-apoptotic Effects of Peganum harmala Leaf Extract on Type 2 Diabetes in the Kidney of Male Wistar Rats

Kajbaf

Oryan

Ahmadi

et al. 2020

Avicenna J Med Biochem

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Background: Growing evidence has shown that the apoptosis of cells plays an important role in the advancement of the Diabetic nephropathy (DN). Objectives: This study attempted to discover the therapeutic potential of Peganum harmala leaf extract in the apoptosis of diabetic kidney disease. Methods: In the present experimental research, 32 male Wistar rats were studied, and diabetes was induced by streptozotocin (STZ) (65 mg/kg). The animals were randomly divided into four groups (n=8, in each group) as follows: control, diabetic, control+leaf extract, diabetic+leaf extract. For our purposes, the methanolic extract of P. harmala leaves (150 mg/kg) was given by gavage for 28 days. Flow cytometry and real-time polymerase chain reaction (PCR) analyses were utilized to determine the percentages of apoptotic cells. Also, histological alterations and blood biochemical parameters were evaluated. Results: The P. harmala leaf extract has a high amount of flavonoids (25.84%), a lower percentage of alkaloids (0.14%), and some antioxidant properties. Serum urea (P<0.001) and apoptosis (P<0.05) significantly elevated in diabetic rats relative to the control ones. The mean of fasting blood creatinine, urea, and albumin level was not significantly changed in diabetic+leaf extract rats as compared to the diabetic ones. Histopathological results also displayed that diabetic complications in the kidney could not be improved following treatment by the leaf extract of P. harmala. In addition, the leaf extract could not significantly reduce the apoptosis and caspase-3 expression compared to diabetics in renal cells. Conclusion: Based on our findings, the leaf extract of P. harmala is unable to inhibit apoptosis in the diabetic kidney model.

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“…I G U R E 2 The chemical structure of 1-Thioformyl-8-dglucopyranoside-bis-bis-2,3-dihydroisopyridineopyrrol, which has been identified in the ingredients of Ph.L. leaves 22,23.…”

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confidence: 99%

In situ green synthesis of hybrid lead nanoparticles encased in phytochemicals for antimicrobial applications

Moustafa

2023

Env Prog and Sustain Energy

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Previously, organic immobilization matrices were used, but this study demonstrates a novel approach by utilizing in situ‐produced phytochemicals to encase the lead nanoparticles. The process involves reducing lead acetate with ingredients from Peganum harmala leaves to create a hydride‐lead nanoparticle‐phytochemical grid. To investigate the morphology and synthesis of the lead nanoparticles, a variety of spectroscopic and microscopic methods were employed. The available information indicates that the hybrid PbNPS exhibits an average nucleation site size of 14.60, indicating the presence of nanoparticles with relatively uniform sizes ranging from 12 to 19. Furthermore, the hybrid PbNPS displayed remarkable antibacterial efficacy against Staphylococcus aureus and Escherichia coli, with inhibition zones measuring 28 and 30.0 mm, respectively, when tested at a concentration of 200 μg/mL. This finding highlights two significant aspects of this research. First, the utilization of phytochemicals as a collector for the straightforward extraction of toxic lead from an aqueous medium represents a novel and innovative approach. Second, the extracted material exhibits promising antibacterial activity, presenting potential applications in the fight against bacterial infections.

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In vitro antibacterial activity of Peganum harmala (L) extract to some fish pathogenic bacteria

Cited by 3 publications

References 21 publications

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

Assessment of the Anti-apoptotic Effects of Peganum harmala Leaf Extract on Type 2 Diabetes in the Kidney of Male Wistar Rats

In situ green synthesis of hybrid lead nanoparticles encased in phytochemicals for antimicrobial applications

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