In Vitro Antibacterial Activity of 4-Phenyl-1-(2-phenyl-allyl)pyridinium bromide: A Novel Class of Pyridinium Based Antibacterial Compounds

Abstract

The continuing increase in the incidence of multi drug resistant pathogenic bacteria and shortage of new antimicrobial agents are the prime driver in efforts to identify the novel antimicrobial classes. In vitro antibacterial activity of 4-phenyl-1-(2-phenylallyl) pyridinium bromide was tested against Gram positive Staphylococcus aureus, Streptococcus species, Bacillus subtilis, and Gram negative Klebsiella aerogenes and Escherichia coli using disk diffusion method. Among them S. aureus showed strong antibacterial activity (21.99 ± 0.03 mm) while E. coli showed very little activity (8.97 ± 0.06 mm) towards the compound. The MIC of 4-phenyl-1-(2-phenyl-allyl)-pyridinium bromide for 90% S. aureus was B20 lg/ml and was compared with phenoxymethylpenicillin, cloxacillin, erythromycin and vancomycin. When 4-phenyl-1-(2-phenyl-allyl)pyridinium bromide showed MIC at B20 lg/ml, all others showed MIC at B100 lg/ml. Strong antibacterial activity of 4-phenyl-1-(2-phenylallyl)pyridinium bromide against S. aureus indicates that there is a possibility to use it as an effective antibacterial agent.

Microwave‐Assisted Rapid and Efficient Synthesis of New Series of Chromene‐Based 1,2,4‐Oxadiazole Derivatives and Evaluation of Antibacterial Activity with Molecular Docking Investigation

“…A wide variety of approaches are being used in the search for novel antibacterial agents . For a long period of time, natural products are still one of the major sources of new antibacterial agents . Following in this vein, it was apparent that heterocycles containing nitrogen(s) and an oxygen atom particularly oxadiazoles have received considerable attention in the field of medicinal chemistry due to their interesting and diverse clinical applications such as antibacterial , antifungal , anthelmintic , antitubercular , anticancer , anti‐HIV , antioxidant , anti‐inflammatory , and anticonvulsant activities (Fig.…”

Microwave Assisted Synthesis of Pyridin-1-ium Salt of 6-Nitroquinazolin-4-one and its 6-Amino Analog under Ultrasonic Irradiation

“…Nitration of 2 with fuming nitric acid in concentrated sulfuric acid at room temperature to obtain 2-bromomethyl-6-nitroquinazolin-4-one (3) and then microwave irradiation of solution of 3 and pyridine in acetonitrile at power level 30 % for 3 min to provide 1-[(6nitroquinazolin-4-one-2-yl)methyl]pyridin-1-ium bromide (4). In the last step, suspension of 4 in mixture of ethanol, glacial acetic acid and water was reduced with iron under sonication at 30 °C for 1 h to get 1-[(6-aminoquinazolin-4-one-2-yl)methyl]pyridin-1-ium bromide (5).…”

“…On the other hands, some of pyridium salts exhibit antibacterial acitivity. The pyridinium salts of phenacyl were obtained by the reaction of phenacyl halide in chloroform at room temperature for overnight at a dark place, while the pyridium salts of alkyl were obtained by the reaction of corresponding alkyl halide and pyridines in appropriate solvents, heated at reflux for 6-50 h [4][5][6] . Microwave (MW) and ultrasonic irradiation has attracted considerable attention for rapid synthesis of organic compounds [7][8][9] .…”

Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea Europaea L.)

“…The antimicrobial activity of hydroxytyrosol acetate was detected via agar diffusion assay as previously described (Jayatissa, et al 2002). Briefly, 100μL of adjusted bacterial diluents were uniformly spread on 2216E plates using a glass spreader.…”