In vitro antiaging activity of polyphenol rich Polyalthia longifolia (Annonaceae) leaf extract in Saccharomyces cerevisiae BY611 yeast cells

Hemagirri, Manisekaran; Sasidharan, Sreenivasan

doi:10.1016/j.jep.2022.115110

Cited by 7 publications

(7 citation statements)

References 62 publications

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“…In traditional medicines various herbal preparations being used to treat duodenal ulcers. The plant has been used in traditional medicine to treat fever, skin diseases, diabetics, anti-aging, hypertension and helminthiasis [ 30 , 31 ]. The bark of P. longifolia has also been found to have some therapeutic importance.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of silver nanoparticles employing Polyalthia longifolia leaf extract and their in vitro antifungal activity against phytopathogen

Dashora

Rathore

Raj

et al. 2022

Biochemistry and Biophysics Reports

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Section: Introductionmentioning

confidence: 99%

Synthesis of silver nanoparticles employing Polyalthia longifolia leaf extract and their in vitro antifungal activity against phytopathogen

Dashora

Rathore

Raj

et al. 2022

Biochemistry and Biophysics Reports

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“…Polyphenols with strong antioxidant activity are often identified as anti-aging agents that help to slow down cellular aging [ 50 ], which may aid to delay the aging of S. cerevisiae . Similar activities to delay yeast aging have been reported in other medicinal herbs, such as clove extract, roselle petal extract, and Polyalthia longifolia leaf extract, which may account for their significant antioxidant activity [ 27 , 51 ]. In addition, LC extracts were proved to significantly extend the mean and maximum lifespan of C. elegans [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 56%

“…In addition, S. cerevisiae viability after WEL treated for 4 days was also detected by spotting test [ 26 , 27 ]. Briefly, S. cerevisiae were re-suspended in sterile PBS and diluted to 10 6 , 10 5 , 10 4 , and 10 3 cells/mL.…”

Section: Methodsmentioning

confidence: 99%

Water extract from Ligusticum chuanxiong delays the aging of Saccharomyces cerevisiae via improving antioxidant activity

Yan

Zhou

et al. 2023

Heliyon

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“…Moreover, MEPL also showed good cytotoxicity against HeLa cancer cells via inducing apoptotic cell death and miRNA regulation [ 71 , 72 , 73 , 74 ]. A recent study also showed that MEPL exhibited good antiaging activities in S. cerevisiae by modulating oxidative stress, enhancing GSH content, and increasing SOD and SIRT1 gene expression [ 75 ].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Antimicrobial Activity of Ceftriaxone and Polyalthia longifolia Methanol (MEPL) Leaf Extract against Methicillin-Resistant Staphylococcus aureus and Modulation of mecA Gene Presence

et al. 2023

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Medicinal plants are an essential source of traditional curatives for numerous skin diseases. Polyalthia longifolia (Sonn.) Thwaites (Annonaceae family) is a medicinal plant used to cure skin illnesses. P. longifolia is usually applied in folkloric therapeutical systems to treat skin diseases. The methicillin-resistant Staphylococcus aureus (MRSA) bacteria is among the essential bacteria contributing to skin diseases. Hence, to verify the traditional medicinal claim of P. longifolia usage in skin disease treatment, the current research was performed to study the synergistic antibacterial activity of standardized Polyalthia longifolia methanol leaf extract (MEPL) against MRSA bacteria. The synergistic antimicrobial activity result of ceftriaxone, when mixed with MEPL, against MRSA was investigated by the disc diffusion method, broth microdilution method, checkerboard dilution test, and modulation of mecA gene expression by multiplex polymerase chain reaction (multiplex PCR). The MEPL extract exhibited good synergistic antimicrobial activity against MRSA. Using the checkerboard method, we confirmed the synergistic effect of MEPL from P. longifolia and ceftriaxone (2:1) for MRSA with a marked reduction of the MIC value of the ceftriaxone from 8000 µg/mL to 1000 µg/mL. Moreover, the combination of MEPL with ceftriaxone significantly (p < 0.05) inhibited the presence of the resistant mecA gene in the tested strain. The LC–ESI–MS/MS analysis identified compounds that were reported to exhibit antimicrobial activity. Conclusively, the MEPL extract, an important etiological agent for skin diseases, showed worthy synergistic antimicrobial action against MRSA bacteria, thus supporting the traditional use of P. longifolia.

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In vitro antiaging activity of polyphenol rich Polyalthia longifolia (Annonaceae) leaf extract in Saccharomyces cerevisiae BY611 yeast cells

Cited by 7 publications

References 62 publications

Synthesis of silver nanoparticles employing Polyalthia longifolia leaf extract and their in vitro antifungal activity against phytopathogen

Synthesis of silver nanoparticles employing Polyalthia longifolia leaf extract and their in vitro antifungal activity against phytopathogen

Water extract from Ligusticum chuanxiong delays the aging of Saccharomyces cerevisiae via improving antioxidant activity

Synergistic Antimicrobial Activity of Ceftriaxone and Polyalthia longifolia Methanol (MEPL) Leaf Extract against Methicillin-Resistant Staphylococcus aureus and Modulation of mecA Gene Presence

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