In vitro anti-Toxocara vitulorum effect of silver nanoparticles

Bahaaeldine, Manar Ahmed; Garhy, Manal El; Fahmy, Sohair R.; Mohamed, Ayman Saber

doi:10.1007/s12639-021-01464-0

Cited by 6 publications

(3 citation statements)

References 60 publications

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“…Nitric oxide is highly reactive with other concentrated oxidizing molecules such as ROS, producing reactive nitrogen that can attack biological systems, leading to severe irreversible damage to biomolecules and cellular damage. However, the anti-creep efficiency of AgNPs against nematodes in vivo remains to be investigated [ 103 ]. Further studies on the in vivo studies and potential value of AgNPs against Toxoplasma gondii are needed [ 104 ].…”

Section: Antiprotozoal Effect Of Agnpsmentioning

confidence: 99%

Application of Silver Nanoparticles in Parasite Treatment

et al. 2023

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Silver nanoparticles (AgNPs) are ultra-small silver particles with a size from 1 to 100 nanometers. Unlike bulk silver, they have unique physical and chemical properties. Numerous studies have shown that AgNPs have beneficial biological effects on various diseases, including antibacterial, anti-inflammatory, antioxidant, antiparasitic, and antiviruses. One of the most well-known applications is in the field of antibacterial applications, where AgNPs have strong abilities to kill multi-drug resistant bacteria, making them a potential candidate as an antibacterial drug. Recently, AgNPs synthesized from plant extracts have exhibited outstanding antiparasitic effects, with a shorter duration of use and enhanced ability to inhibit parasite multiplication compared to traditional antiparasitic drugs. This review summarizes the types, characteristics, and the mechanism of action of AgNPs in anti-parasitism, mainly focusing on their effects in leishmaniasis, flukes, cryptosporidiosis, toxoplasmosis, Haemonchus, Blastocystis hominis, and Strongylides. The aim is to provide a reference for the application of AgNPs in the prevention and control of parasitic diseases.

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Section: Antiprotozoal Effect Of Agnpsmentioning

confidence: 99%

Application of Silver Nanoparticles in Parasite Treatment

et al. 2023

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“…Additionally, cattle and buffalo are susceptible to Toxocariasis due to the gastrointestinal worm Toxocara vitulorum. Mohamed and colleagues [149] investigated the anthelmintic effects of Ag-NPs on both male and female worms as a result of drug resistance. Changes in body structure and the possible intake of drugs were identified.…”

Section: Inorganic Nmsmentioning

confidence: 99%

Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges

Sadiq,

Khan,

Shen

et al. 2023

Molecules

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Pathogens cause infections and millions of deaths globally, while antipathogens are drugs or treatments designed to combat them. To date, multifunctional nanomaterials (NMs), such as organic, inorganic, and nanocomposites, have attracted significant attention by transforming antipathogen livelihoods. They are very small in size so can quickly pass through the walls of bacterial, fungal, or parasitic cells and viral particles to perform their antipathogenic activity. They are more reactive and have a high band gap, making them more effective than traditional medications. Moreover, due to some pathogen’s resistance to currently available medications, the antipathogen performance of NMs is becoming crucial. Additionally, due to their prospective properties and administration methods, NMs are eventually chosen for cutting-edge applications and therapies, including drug administration and diagnostic tools for antipathogens. Herein, NMs have significant characteristics that can facilitate identifying and eliminating pathogens in real-time. This mini-review analyzes multifunctional NMs as antimicrobial tools and investigates their mode of action. We also discussed the challenges that need to be solved for the utilization of NMs as antipathogens.

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“…As a result of increasing drug resistance and unfavourable side effects, there is a need to develop novel alternative effective anthelmintic drugs against T. vitulorum [96]. Venjakob and Ahmad, along with their co-workers [97,98], investigated the anthelmintic effects of AgNPs on male and female T. vitulorum, in vitro. A silver nitrate base with lemon juice as a reducing agent was used to biosynthesize silver nanoparticles.…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

An Insight into the Global Problem of Gastrointestinal Helminth Infections amongst Livestock: Does Nanotechnology Provide an Alternative?

et al. 2023

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Helminth parasitic infections are a considerable constraint to the livestock industries worldwide. Nematode parasites cause the major proportion of harm to livestock. The infections caused are accountable for severe economic losses in cattle, goat and sheep farming industries. Morbidity and mortality in livestock due to parasitic diseases are increasing alarmingly. Also, their zoonotic influence on human health is considered significant. Anthelmintic drugs have been developed occasionally to curb this disease and prevent major losses. But the development of resistance against these drugs has put another constraint on this flourishing industry. Helminth parasites have developed resistance against three main classes of anthelmintics: benzimidazoles, macrocyclic lactones and nicotinic agonists. With the intensification of resistance, various screening and confirmatory tests have been developed for the speedy introduction of newer drugs in the livestock industry. At the same time, designing and launching novel anthelmintics is time-consuming and economically restrained. Phytochemicals attract much attention because of their pharmacotherapeutic potential, least toxic profile and low environmental hazards. A lot of work is going on plant-based anthelmintic drugs throughout the world. Plants possessing anthelmintic activity have been found efficacious against gastrointestinal parasites. Nevertheless, these herbal medicines have various drawbacks, which include poor efficacy and the absence of target selectivity. These problems are now being taken care of with the help of nanotechnology. Nanoparticles improve the drug’s effectiveness, enhance drug delivery, and target selectivity at specific sites. A comprehensive literature survey was carried out via electronic searches of Google Scholar, PubMed, MEDLINE, Science Direct, Scopus and Cochrane Library databases and based on inclusion and exclusion criteria; articles were selected for this review. The review aims at providing a comprehensive overview of plant-based nanoparticles as therapeutic alternatives over conventional synthetic anthelmintic drugs. It also encompasses the methods of detection of resistance and the ways to overcome this menace. The effectiveness of various organic and inorganic nanoparticles against helminthes is also discussed in this review.

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In vitro anti-Toxocara vitulorum effect of silver nanoparticles

Cited by 6 publications

References 60 publications

Application of Silver Nanoparticles in Parasite Treatment

Application of Silver Nanoparticles in Parasite Treatment

Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges

An Insight into the Global Problem of Gastrointestinal Helminth Infections amongst Livestock: Does Nanotechnology Provide an Alternative?

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