In Vitro Anti-Proliferative Activity of Curcuma Angustifolia and Estimation of Bioactive Compounds for Antioxidant Activity

Abstract

Abstract:The present work deals with preliminary in-vitro studies to validate the traditional claims of medicinal properties in consuming Curcuma flowers to make the person less susceptible to diseases and the estimation of bioactive compounds responsible for antioxidant activity present. The anti-proliferative activity of aqueous extracts of budding flowers, leaves, full bloomed flowers and mixture of all parts of Curcuma angustifolia was studied using MDCK, Vero and HeLa cell lines. The inhibitory activity in all the three cell lines was found to be dose dependent. The extract of leaves and budding flowers exhibited higher inhibitions in MDCK and Vero cells while the full bloomed flowers extract showed higher inhibitory activities in HeLa cells. The bioactive compounds-total phenolics content ranged from 56.96 to 86.77 mg GEA/100 gm which was highest in full bloomed flowers, total flavonoids and the free radical scavenging activity content ranged from 84.74 to 166.11 mg CE/100 g and 43.91 to 64.02 mg AEAC/100 gm respectively, with maximum content in budding flowers. The result showed potential anti-proliferative and antioxidant properties that substantiate the belief of the indigenous people to include the plant in their dietary habits which could be exploited for use in preparation of herbal drugs and supplements.

Phytopharmaceutical characterization of Curcuma angustifolia Roxb. collected from Manipur, India

“…Traditionally, rhizomes are used as an appetizer to relieve burning and stomach discomfort, demulcent, antipyretic, and blood clotting, and the decoction of the rhizome's water is used to treat diabetes and remove kidney stones (Tushar et al 2010, Sheikh et al 2015. The biological potency of the plant part is a rhizome, it contains secondary metabolites that play an important role in healing various diseases, such as antifungal (Doble et al 2011) and antibacterial properties (Jadhao et al 2017), as well as antioxidant properties (Assumi et al 2017). It is also beneficial for patients with ulcers (Sharma R. 2003).…”