In Vitro Anti – Inflammatory Activity of the Flowers of Nerium Oleander (White)

Abstract

Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. It is characterized by redness, swollen joints, joint pain, its stiffness and loss of joint function. Inflammation is currently treated by NSAIDs. Unfortunately these drugs cause increased risk of blood clot resulting in heart attacks and strokes. Therefore, the developments of potent anti-inflammatory drugs from the natural products are now under considerations. Natural products are rich source for discovery of new drugs because of their chemical diversity. A natural product from medicinal plants plays a major role to cure many diseases associated with inflammation. The conventional drug available in the market to treat inflammation produces various side-effects. In this present study anti-inflammatory potential of Nerium Oleander was investigated. Based on the resulted the ethonolic extract of the flowers showed the highest anti inflammatory activity. The increments in absorbance of test samples with respect to control indicated stabilization of protein i.e. inhibition of heat-induced protein (albumin) denaturation by Nerium oleander and reference drug diclofenac sodium.

Synthesis, Characterization and Bio-Potential Activities of Co(II) and Ni(II) Complexes with O and N Donor Mixed Ligands

“…The amount of sample needed to inhibit free radicals concentration by 50%, IC 50 , was graphically determined by a linear regression method using Ms-Windows-based GraphPad Instate (version 3) software. Results were expressed as graphically/mean ± standard deviation [17].…”

Anti-inflammatory Activity of Ethanolic Leaf Extracts of Thaumatococus Danielli on Iodoacetamide Treated Rats

“…Also, genomic changes in p53 have been strongly associated with the causes of many of these chronic inflammatory diseases (Kong, 2013, Ogrunc et al, 2014, Niederhuber et al, 2013. NSAIDs have long been the antidote for inflammations; unfortunately, these drugs have been associated with increased blood clotting risk which ultimately results in heart attacks, strokes, etc (Kumar et al, 2013, Mary et al, 2017, Vijayabaskar and Elango, 2018. Thus, the formulations of effective and non-toxic or less toxic antiinflammatory drugs from natural source (plants) have been considered worldwide for more than a decade now.…”