In vitro Anti-inflammatory activity of Silymarin/Hydroxyapatite/Chitosan Nanocomposites and its cytotoxic effect using Brine shrimp lethality assay

Abstract

Silymarin, a bioactive compound, is one of the most prominent drugs used in liver diseases. Chitosan and hydroxyapatite (HAP) are the major materials used employed in many biomedical processes like drug delivery, osteointegration, etc. The nanoparticles and nanocomposites are advanced materials with many biomedical applications in diagnosis and therapeutics. In this study, HAP and chitosan were used as a polymeric material, silymarin as a bioactive compound, and other nanoparticle based combinations. The prepared individual materials and nanocomposites were used for the anti-inflammatory activity and brine shrimp lethality assay. The results clearly show that the nanocomposites are good anti-inflammatory agents with lower toxicity.

Antibacterial Activity Against Multidrug-Resistant Clinical Isolates of Nine Plants from Chencha, Southern Ethiopia

“…65 The extent of cytotoxic activity of S. marianum found in our study was by and large similar to that reported earlier. 66 A slight discrepancy in LD 50 values reported by various authors may be attributed to the difference in seasonality, the geographical distribution of plants, the age and parts of the plant used, the method of extraction, and the solvent type.…”

Preparation of Camellia sinensis (Green Tea) and Acacia nilotica (Babul) Herbal Formulation and its Anti-Inflammatory Activity

“…EGCG is regarded to offer therapeutic value in a variety of inflammatory disorders, including atherosclerosis, arthritis, and dry eye disease. [8] There are studies which demonstrate anti-inflammatory [9] activity using green tea and babul as two separate compounds. Hence the aim of this present study is to assess the combined effects of green tea and babul herbal formulation as an anti inflammatory agent.…”