In vitro anti-inflammatory activity of fractionated Euphorbia hirta aqueous extract on rabbit synovial fibroblasts

Chen, Jocelyn; Er, Hui Meng; Mohamed, Shar Mariam; Chen, Yu Sui

doi:10.4103/2319-4170.151031

Cited by 9 publications

(4 citation statements)

References 20 publications

(26 reference statements)

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“…E. hirta also inhibits the survival of MCF-7 cells with a half inhibitory concentration (IC50) value of 25.26 µg/mL at 24 h (Kwan et al, 2016). Chen et al (2015) described the in vitro anti-inflammatory activity of fractionated E. hirta aqueous extract on rabbit synovial fibroblasts. Toyin et al (2012) showed antidiarrheal activity of aqueous leaf extract of Ceratotheca sesamoides in rats, while extract from leaves have antiviral activities (Obi et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

Bayala¹,

Zohoncon²,

Djigma³

et al. 2020

Int. J. Bio. Chem. Sci

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Medicinal plants are a potential source of drug discovery and development of cancer chemoprevention drugs. Thus, the aim of this work was to study the antioxidant and antiproliferative activities of hydromethanolic extracts of Musa sapientum L., Cassia italica (Mill.) Spreng., Crateva adansonii DC., Euphorbia hirta L. and Ceratotheca sesamoides Endl. from Burkina Faso. The antioxidative activity of hydromethanolic extracts of plant was assessed using DPPH radical scavenging assay and ABTS+ radical cation decolorisation assay. Antiproliferative activity was evaluated by MTT assay. Of these five plant extracts, hydromethanolic extract of Euphorbia hirta leaf twigs showed the best antioxidant activity both by DPPH (IC50 = 0.53 ± 0.04 μg extract / μg DPPH) and ABTS (C = 0.302 ± 0.003 μMET / g extract) methods. In addition, hydromethanolic extract of Euphorbia hirta leaf twigs showed the best antiproliferative activity on LNCaP cell lines of prostate cancer while the hydromethanolic extract of the Ceratotheca sesamoides leaf stems showed the best antiproliferative activity on the HeLa cell lines of cervical cancer. This work has shown not only the antioxidant and anticancer activities of these five local plants, but also the potential valorization of these species used in traditional medicine in Burkina Faso.Keywords: Cancer, antioxydant, antiproliferative, Medicinal plants, Burkina Faso.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

Bayala¹,

Zohoncon²,

Djigma³

et al. 2020

Int. J. Bio. Chem. Sci

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“…Phorbol myristate was used to activate Rabbit synovial fibroblasts cells HIG-82 and then treated with the fractions. More than the other crude aqueous extracts, the aqueous extract suppressed the generation of PGE2 [27].…”

Section: Anti-inflammatory Activitymentioning

confidence: 83%

“…Basyal et al evaluated the antioxidant activity using the DPPH free radical scavenging assay, the antioxidant activity IC50 of the ethyl acetate extract from the aerial parts of E. hirta was determined to be 32.23µg/ml [27].…”

Section: Antioxidant Activitymentioning

confidence: 99%

A systematic exploration of pharmacological attributes and phytochemical components in Euphorbia hirta Linn: A mini review

Sengottuvelu S, Sibi K,

Angelin Staffin S,

Rajasimman V

et al. 2023

World J. Bio. Pharm. Health Sci.

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In several nations, including India and China, herbal medications are integral parts of traditional medicine. India is home to the well-known medicinal system known as Ayurveda. For thousands of years, Ayurveda, Siddha, and Unani, three of India's traditional medicinal systems, have been used. Herbal medicines are the earliest known forms of human healing. India is well-known around the globe for its Ayurvedic medicine. Euphorbia hirta has been traditionally used to treat a variety of conditions, including gonorrhea, diarrhea, jaundice, acne, worm infestations in youngsters, feminine diseases, and digestive issues and tumors. The white milky latex of this plant has an incredible health impact on human health. Alkanes, triterpenes, phytosterols, tannins, polyphenols, and flavonoids are all said to be present. This mini-review of the data collection of the past ten years, presents the traditional uses, chemical constituents, medicinal properties, and some future aspects to promote the use of E. hirta in the improvement of human health.

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“…The ethanol extract was shown to inhibit all enzymes with IC 50 values of 63.5, 81.2, 92.1 and 30.5 µg/mL respectively (Li et al 2004). The whole plant of E. hirta was extracted using four solvents, i.e.. n-hexane, chloroform, methanol and water via soxhlet extraction (Chen et al 2015). The study revealed that fractionation of the aqueous extract had a more promising anti-inflammatory action via an inhibitory effect on prostaglandin E2 (PGE2), a principal mediator of inflammation, compared to the crude aqueous extract.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Antimicrobial and anti-inflammatory activities of australian native plants in the context of wound healing: A review

Manirujjaman

Collet

2020

Biologia

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Wound healing is an essential biological process which involves tissue repair and recovery and includes the action of a complex system of blood cells, cytokines, and growth factors. It is a process attended by integrated cellular and biochemical events and characterized by four phases: haemostasis, inflammation, proliferation, and remodelling. Medicinal plants which have healing applications, continue to play a central role in the healthcare system of a large proportion of the world's population. Numerous studies have shown that several Australian plant species used medicinally, contain biologically active extracts and compounds which have enormous potential for the treatment and management of a wound. Medicinal plants contain a wide range of chemical compounds as the unique flora of Australia offers an array of diverse bioactives, which elicit antibacterial, antioxidant, antiinflammatory and wound healing abilities. Such properties are not limited to the edible sections of plants as the roots, bark, sap, leaves and seeds from a vast array of plants have demonstrated similar effects. In this review article, various Australian native plants which are scientifically proven to have antibacterial and anti-inflammatory properties that support wound healing, are discussed. This review also briefly discusses the general wound healing process, wound-colonizing bacteria, factors that affect wound healing, and costs involved in the treatment and management of chronic wounds.

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In vitro anti-inflammatory activity of fractionated Euphorbia hirta aqueous extract on rabbit synovial fibroblasts

Cited by 9 publications

References 20 publications

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

A systematic exploration of pharmacological attributes and phytochemical components in Euphorbia hirta Linn: A mini review

Antimicrobial and anti-inflammatory activities of australian native plants in the context of wound healing: A review

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