In vitro anti-inflammatory activity of Phlebodium decumanum. Modulation of tumor necrosis factor and soluble TNF receptors

Punzón, Carmen; Alcaide, Antonio Montero; Fresno, Manuel

doi:10.1016/s1567-5769(03)00117-6

Cited by 26 publications

(20 citation statements)

References 12 publications

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“…It provides protection against hepatotoxicity most likely because the inhibition of cell growth leads to a decrease in 18 inflammation levels . This correlation was also made by 19 Punzon , who used hydromethanolic extracts of Phlebodium decumanum Willd. (Polypodiaceae) to demonstrate that the inhibition of cellular growth was accompanied by decreased levels of IL-1 and TNF.…”

Section: Discussionmentioning

confidence: 71%

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Potencial anti-Leishmania e imunomodulador dos extratos de Campsiandra laurifolia Benth. (Fabaceae)

Chagas¹,

Müller

Soares

et al. 2010

Rev Pan-Amaz Saude

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Infusions of leaves, bark and seeds of Campsiandra laurifolia Benth. (Fabaceae) are used by communities of AfricanAmerican descendants of slaves (quilombolas) mainly for treatment of cutaneous leishmaniasis (CL), wounds, ulcers and tinea. Hydroalcoholic and aqueous extracts of C. laurifolia were investigated for anti-Leishmania activity on promastigotes and amastigotes of Leishmania (L.) amazonensis and immunomodulatory responses, including cell proliferation of splenocytes and NO production by peritoneal macrophages from BALB/c mice. The hydroalcoholic extracts of the bark and the aqueous extracts of the leaves and seeds presented a reduced activity against amastigotes and promastigotes (<20%), and the same result was observed for the inhibition of NO production by activated macrophages (<23%). Most of the extracts displayed a moderate immunosuppressive potential (32.6 to 38.5%); on the other hand, the aqueous extracts of seeds inhibited up to 87% of the growth of splenocytes of BALB/c mice stimulated with mitogens. Such activity may explain the use of C. laurifolia for the treatment of CL by quilombolas. Its use may not be mainly associated with a direct action on the parasite but with an anti-inflammatory activity because such activity decreases the tissue damage caused by the immune system in response to the infection and, consequently, aids the healing process of leishmanial lesions.

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Section: Discussionmentioning

confidence: 71%

“…However, regardless of the mode of drug action, inhibition of cell proliferation appears to be associated with anti-inflammatory activity, as the reduction of cell growth implies a decrease in both soluble receptors produced by these cells and proteases that convert inactive precursors 19 into active ones .…”

Section: Discussionmentioning

confidence: 99%

Potencial anti-Leishmania e imunomodulador dos extratos de Campsiandra laurifolia Benth. (Fabaceae)

Chagas¹,

Müller

Soares

et al. 2010

Rev Pan-Amaz Saude

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“…M. quadrifolia has been used to treat human breast cancer, diabetes, and snake bites, and as an anti-inflammatory and diuretic (Uma and Pravin, 2013). The bear paw fern, Phlebodium decumanum has been used for anti-cancer, ulcer, and high blood pressure treatments (Punzon et al, 2003). The leaves and rhizomes of H. arifolia (Burm.)…”

Section: Anti-cancer Antidiabetic and Antiviral Activitymentioning

confidence: 99%

A review of the use of pteridophytes for treating human ailments

Xavier-ravi

Vigila

Zhang

et al. 2018

J. Zhejiang Univ. Sci. B

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Abstract:The aim of this review was to explore the pharmacological activity of early tracheophytes (pteridophytes) as an alternative medicine for treating human ailments. As the first vascular plants, pteridophytes (aka, ferns and fern allies) are an ancient lineage, and human beings have been exploring and using taxa from this lineage for over 2000 years because of their beneficial properties. We have documented the medicinal uses of pteridophytes belonging to thirty different families. The lycophyte Selaginella sp. was shown in earlier studies to have multiple pharmacological activity, such as antioxidant, anti-inflammatory, anti-cancer, antidiabetic, antiviral, antimicrobial, and anti-Alzheimer properties. Among all the pteridophytes examined, taxa from the Pteridaceae, Polypodiaceae, and Adiantaceae exhibited significant medicinal activity. Based on our review, many pteridophytes have properties that could be used in alternative medicine for treatment of various human illnesses. Biotechnological tools can be used to preserve and even improve their bioactive molecules for the preparation of medicines against illness. Even though several studies have reported medicinal uses of ferns, the possible bioactive compounds of several pteridophytes have not been identified. Furthermore, their optimal dosage level and treatment strategies still need to be determined. Finally, the future direction of pteridophyte research is discussed.

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“…Thereafter literature survey revealed the presence of anti-inflammatory activity 12 , antioxidant 13 , wound healing, improve immune system 14 , antimicrobial, anthelmintic 10 etc. Henceforth therapeutic activities of plant constituents are greatly depend on the soil fertility, climatic conditions and content of metal ions in the accumulated plant parts [15][16][17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening, metallic ion content and from its impact on Anti psoriasis activity of Calendula officinalis and Phlebodium decumanum aqueous leaf extracts in animal experiment model

Das¹,

Deb²,

Karanth³

2018

tjps

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ObjectiveThe aim of this study is to evaluate the influence of metal ions present in soil as well as in the leaves samples of Calendula officinalis and Phlebodium decumanum for the treatment of psoriasis. MethodsLooking at the objective, soils and leaves samples were estimated for metal ions by atomic absorption spectrophotometer to determine the influence in anti-psoriatic activity. Thereafter Imiquimod-induced dermatitis lesions were created in grouped mouse. Two plant extracts (aqueous) separately as well as in combinations and standard Retino-A (0.05%) were used.Psoriasis severity index (PSI) was evaluated by phenotypic (redness, erythema, and scales) and histological features (epidermal thickness). Further content of phytochemicals in terms of extract was correlated with the effect of psoriasis activity. Results:We observed redness, erythema and scales and the histological features and found a progressive reduction (P < 0.05) in the severity of psoriatic lesions (redness, erythema, and scales) from day 7 to 21 st day and decreased epidermal thickness in animals treated with combined extracts at the dose of 200 mg/kg b.w. Furthermore plant samples procured from Nandi Hill's, Bangalore, showed better uptake of metals with respect to Fe (2.05 mg/kg), Cu (0.78 mg/kg) and Zn (1.12 mg/kg) which showed positive impact on procurement of maximum amount of extracts that further correlated with the activity, indicated significant reduction of psoriatic lesions. ConclusionResults revealed that significant dose dependent antipsoriasis activity of combined aqueous extracts of Calendula officinalis and Phlebodium decumanum as well as metal ions are also had impact on the procurement of extracts and said activity.

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In vitro anti-inflammatory activity of Phlebodium decumanum. Modulation of tumor necrosis factor and soluble TNF receptors

Cited by 26 publications

References 12 publications

Potencial anti-Leishmania e imunomodulador dos extratos de Campsiandra laurifolia Benth. (Fabaceae)

Potencial anti-Leishmania e imunomodulador dos extratos de Campsiandra laurifolia Benth. (Fabaceae)

A review of the use of pteridophytes for treating human ailments

Phytochemical screening, metallic ion content and from its impact on Anti psoriasis activity of Calendula officinalis and Phlebodium decumanum aqueous leaf extracts in animal experiment model

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