Potencial anti-Leishmania e imunomodulador dos extratos de Campsiandra laurifolia Benth. (Fabaceae)

Abstract

Infusions of leaves, bark and seeds of Campsiandra laurifolia Benth. (Fabaceae) are used by communities of AfricanAmerican descendants of slaves (quilombolas) mainly for treatment of cutaneous leishmaniasis (CL), wounds, ulcers and tinea. Hydroalcoholic and aqueous extracts of C. laurifolia were investigated for anti-Leishmania activity on promastigotes and amastigotes of Leishmania (L.) amazonensis and immunomodulatory responses, including cell proliferation of splenocytes and NO production by peritoneal macrophages from BALB/c mice. The hydroalcoholic extracts of the bark and the aqueous extracts of the leaves and seeds presented a reduced activity against amastigotes and promastigotes (<20%), and the same result was observed for the inhibition of NO production by activated macrophages (<23%). Most of the extracts displayed a moderate immunosuppressive potential (32.6 to 38.5%); on the other hand, the aqueous extracts of seeds inhibited up to 87% of the growth of splenocytes of BALB/c mice stimulated with mitogens. Such activity may explain the use of C. laurifolia for the treatment of CL by quilombolas. Its use may not be mainly associated with a direct action on the parasite but with an anti-inflammatory activity because such activity decreases the tissue damage caused by the immune system in response to the infection and, consequently, aids the healing process of leishmanial lesions.

Antioxidant Evaluation of the Aqueous Extract of Hulls of Campsiandra laurifolia in Colitis Induced by Acetic Acid in Wistar Rats

“…The reduction in LPO in the CL þ A50 group may be associated with the high concentration of tannins present in C. laurifolia, which assist in the interception of active oxygen and in the repair of FRs. 6,[19][20][21] The significant increase in SOD activity is in line with other research, which also used AA to induce colitis. The increased SOD activity is linked to the attempt to dismutate the superoxide anions and, thus, minimize the damage caused by AA.…”

“…Due to these facts, the objective of the present work was to characterize phytochemically the aqueous extract of hulls of C. laurifolia, as well as to evaluate its antioxidant potential in vitro, against 2,2diphenyl-1-picryl-hydrazil (DPPH), and in vivo in the AAinduced colitis model. 6…”

Phytosociology of a natural fragment of the floodplain forest in the Lower Tapajós River, Brazil

“…These results corroborated those found by Ferreira and Prance (1998) that mentioned the Campsiandra laurifolia, Mabea caudata and Tetragastris altissima as important species and stated characteristics of flood-prone areas, therefore they can be recommended for wetlands restoration and flooded riparian areas in the Tapajós River basin. It is worth noting that Campsiandra laurifolia has herbal phytotherapy uses in many of the Amazon rural communities, mainly treating wounds, bruises, malaria and ulcer (Chagas et al 2010). According to Chagas et al (2010), maroons from Arancuã community in the state of western Pará, use the infusion of the leaves, decoction of the bark and tapioca fruit (starchy part obtained from aqueous maceration and drying in sunlight exposure) for cutaneous leishmaniasis treatment.…”

“…It is worth noting that Campsiandra laurifolia has herbal phytotherapy uses in many of the Amazon rural communities, mainly treating wounds, bruises, malaria and ulcer (Chagas et al 2010). According to Chagas et al (2010), maroons from Arancuã community in the state of western Pará, use the infusion of the leaves, decoction of the bark and tapioca fruit (starchy part obtained from aqueous maceration and drying in sunlight exposure) for cutaneous leishmaniasis treatment.…”

Evaluation of the lymphoproliferation of mononuclear cells in cutaneous leishmaniasis patients treated with Libidibia ferrea

“…Associating these phenolic compounds and amphotericin B, Alves (2019) demonstrated the activation of macrophages and a reduction in amastigotes through macrophage, indicating therapeutic action and activation of the immune response, and leading to the healing of lesions in Mus musculus lineage BALB/c. Some studies with herbal compounds, such as Campsiandra laurifolia (Chagas, Henrique Müller, Soares & Garcez, 2010), Portulaca hirsutissima and Portulaca werdermannii (Costa et al, 2007), Nelumbo nucifera (Khan et al, 2016), did not demonstrate direct action on the parasitic agent, but rather, as potential anti-inflammatory treatments with high immunomodulatory capacity in Leishmania sp. infections.…”