In Vitro Anti-Inflammatory Activities of Ethanolic Extract Elephantopus Scaber Leaves

Nurtamin, Tomy; Sudayasa, I Putu; Tien, Tien

doi:10.20885/jkki.vol9.iss1.art9

Cited by 6 publications

(7 citation statements)

References 22 publications

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“…Gmelina arborea [ 83 , 84 ], Elephantopus scaber [ 85 , 86 ], and Duhaldea cappa [ 87 ], were also used for their anti-inflammatory properties. For instance, Gmelina arborea [ 84 ] and Elephantopus scaber [ 85 , 86 ] have flavonoids, tannins, and saponins. Miliusa thorelii and Pothos scandens have been used for curing many MSD categories in this study, such as fractures, joint symptoms, and muscle pains, but any phytochemicals that could affect MSD remain to be documented in these species.…”

Section: Discussionmentioning

confidence: 99%

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Medicinal Plants for Treating Musculoskeletal Disorders among Karen in Thailand

Kantasrila

Pandith

Balslev

et al. 2020

Plants

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Millions of people suffer from Musculoskeletal System Disorders (MSDs), including Karen people who work hard in the fields for their subsistence and have done so for generations. This has forced the Karen to use many medicinal plants to treat MSDs. We gathered data from 15 original references covering 27 Karen communities and we document 461 reports of the use of 175 species for treating MSDs among the Karen people in Thailand. The data were analyzed by calculating use values (UV), relative frequency of citation (RFC) and informant consensus factor (ICF). Many use reports and species were from Leguminosae and Zingiberaceae. Roots and leaves were the most used parts, while the preferred preparation methods were decoction and burning. Oral ingestion was the most common form of administration. The most common ailment was muscle pain. Sambucus javanica and Plantago major were the most important species because they had the highest and second-highest values for both UV and RFC, respectively. This study revealed that the Karen people in Thailand use various medicinal plants to treat MSDs. These are the main resources for the further development of inexpensive treatments of MSDs that would benefit not only the Karen, but all people who suffer from MSD.

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Section: Discussionmentioning

confidence: 99%

Section: Most Preferred Species For Treating Msdmentioning

confidence: 99%

Medicinal Plants for Treating Musculoskeletal Disorders among Karen in Thailand

Kantasrila

Pandith

Balslev

et al. 2020

Plants

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“…Inflammation is a protective physiological response of living tissues to injury (Chou, 1997; Nurtamin et al., 2018; Rajendran et al., 2013). The characteristics of inflammation are heat, swelling, redness, and pain (George, 2006; Prakash, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of solvent—solvent fractionation on the total terpenoid content and in vitro anti‐inflammatory activity of Serevenia buxifolia bark extract

Truong

Pham

et al. 2021

Food Science & Nutrition

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Severinia buxifolia (Rutaceae) is often used as a traditional medical plant. The present study was carried out to estimate the effects of solvents (petroleum ether and hexane: ethyl acetate) used in liquid–liquid extraction to total terpenoid content (TTC) and in vitro anti‐inflammatory activity of the extracts obtained from S. buxifolia bark. The results showed that solvent fractionation increased the TTC compared with crude extracts. The hexane: ethyl acetate bark extract fraction (HEF) had the highest TTC (731.48 µg/ml) in comparison with the petroleum ether bark extract fraction (PEF) (564.81 µg/ml) and the crude extract (CE) (184.26 µg/ml). In addition, one of composition of terpenoid of S. buxifolia, namely ursolic acid, was determined by HPLC method from the crude CE and the fractions PEF and HEF: 2.44 μg/g DW, 3.56 μg/g DW and 5.04 μg/g DW, respectively. The samples had an in vitro anti‐inflammatory activity comparable with that of two reference standards (aspirin and indomethacin). Particularly, the HEF fraction had the highest in vitro anti‐inflammatory activity (i.e., albumin denaturation: IC50 = 147.91 μg/mL, heat‐induced hemolysis: IC50 = 159.91 μg/mL, proteinase inhibition: IC50 = 117.72 μg/mL, and lipoxygenase activity: IC50 = 90.45 μg/mL). Besides, the preliminary experiments of this study were conducted to determine the influences of maceration factors (solvent type, temperature, and time) for S. buxifolia bark extract. The TTC ranged from 453.70 to 842.59 mg linalool/g DW, and the extraction yield from 2.40% to 5.120% in all extracts. Based on TTC and EY, the hexane: acetone mixture is recommended as the optimal solvent to obtain the crude bark extract (CE) at 46°C for 24 hr of maceration. Extracts of S. buxifolia bark are a promising source for the treatment of inflammatory diseases.

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“…Elephantopus scaber L. is a type of plant that can be easily found in Indonesia (Nurtamin et al 2018). This plant is also potentially used as a traditional medicine to treat influenza, headaches, cough, fever, diarrhea, jaundice, hepatitis, laryngitis, anemia, and fluor albus (Arisandi & Andriani 2006;Wang et al 2014).…”

Section: Introductionmentioning

confidence: 99%

“…In previous studies, showed that E. scaber L. can reduce LDL (Low Density Lipoprotein) level and also promising hepatoprotection activity in mice (Daisy et al 2007;Ho et al 2012;Nasri 2012;Puspita 2004;Sankar et al 2001;Sulastri 2008). The leaves of E. scaber L. containing terpenoids, flavonoids, saponins, and tannins which function as antibacterial and antiinflammatory (Bigham et al 2003;Grayson 2000;Lim et al 2006;Nurtamin et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Callus induction and secondary metabolite profile from <i>Elephantopus scaber</i> L.

Junairiah

Wulandari

Utami

et al. 2021

J.Tropical Biodiversity Biotechnology

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Elephantopus scaber L. is a plant that has potential as traditional medicine. Callus induction and production of secondary metabolite content can be increased by culture callus using plant growth regulators. This study was purposed to investigate the effect of IBA and kinetin concentration on the induction and secondary metabolite profile of callus from E. scaber L. leaves. Leaves explant of E. scaber L. were cultured on MS medium with various combination concentrations of IBA and kinetin for 6 weeks and then callus was extracted using methanol. Secondary metabolite content from the resulting extract was analyzed using the phytochemical screening method. The result showed that the treatment of IBA 2.0 mg/L and kinetin 1.0 mg/L and treatment of IBA 2.0 mg/L and kinetin 2.5 mg/L are the fastest combination concentration to induce callus at 5.33 ± 0.577 days. Treatment of IBA 2.0 mg/L and kinetin 2.5 mg/L produced callus with the highest fresh weight and dry weight at 0.7016 ± 0.0588 grams and 0.0766 ± 0.0062 grams, respectively. The morphology of calluses grown during this study was compact with various colors appearance, such as light green, brownish green, and brown. Secondary metabolite content of methanol extract of callus E. scaber L. are flavonoids, alkaloids, terpenoids, and saponins.

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In Vitro Anti-Inflammatory Activities of Ethanolic Extract Elephantopus Scaber Leaves

Cited by 6 publications

References 22 publications

Medicinal Plants for Treating Musculoskeletal Disorders among Karen in Thailand

Medicinal Plants for Treating Musculoskeletal Disorders among Karen in Thailand

Effects of solvent—solvent fractionation on the total terpenoid content and in vitro anti‐inflammatory activity of Serevenia buxifolia bark extract

Callus induction and secondary metabolite profile from <i>Elephantopus scaber</i> L.

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