In vitro anti-cancer efficacy of multi-functionalized magnetite nanoparticles combining alternating magnetic hyperthermia in glioblastoma cancer cells

Minaei, Soraya Emamgholizadeh; Khoei, Samideh; Khoee, Sepideh; Vafashoar, Fatemeh; Mahabadi, Vahid Pirhajati

doi:10.1016/j.msec.2019.04.007

Cited by 59 publications

(21 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PLGA-Fe 3 O 4 -IBUP solutions, obtained by dispersing ~14 mg of lyophilized microspheres in deionized water, were introduced into the Dewar vial and subjected to three magnetic fields, with powers representing 60%, 80%, and 100% from the maximum output power. The temperature evolution of each sample was recorded up to 50 °C (slightly above the 42–45 °C temperature range associated with the occurrence of apoptosis and necrosis of cancer cells) [49,86,87] by using an optical fiber supplied with a TS4 sensor (precision ± 0.2 °C) from Optocon (Dresden, Germany) connected to a PC. In all experiments, deionized water was used as blank specimen.…”

Section: Methodsmentioning

confidence: 99%

“…Magnetically-responsive biomaterials embedded with Fe 3 O 4 nanoparticles have been assessed as multifunctional systems for specific, selective, and performance-enhanced anti-infective [43,44] and anti-cancer applications [45,46], as well as for regenerative medicine [47,48]. In particular, Fe 3 O 4 -based nanostructured systems are promising platforms for successful controlled and targeted drug delivery applications by means of magnetic hyperthermia [41,49,50].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nanomagnetite-embedded PLGA Spheres for Multipurpose Medical Applications

et al. 2019

View full text Add to dashboard Cite

We report on the synthesis and evaluation of biopolymeric spheres of poly(lactide-co-glycolide) containing different amounts of magnetite nanoparticles and Ibuprofen (PLGA-Fe3O4-IBUP), but also chitosan (PLGA-CS-Fe3O4-IBUP), to be considered as drug delivery systems. Besides morphological, structural, and compositional characterizations, the PLGA-Fe3O4-IBUP composite microspheres were subjected to drug release studies, performed both under biomimetically-simulated dynamic conditions and under external radiofrequency magnetic fields. The experimental data resulted by performing the drug release studies evidenced that PLGA-Fe3O4-IBUP microspheres with the lowest contents of Fe3O4 nanoparticles are optimal candidates for triggered drug release under external stimulation related to hyperthermia effect. The as-selected microspheres and their chitosan-containing counterparts were biologically assessed on macrophage cultures, being evaluated as biocompatible and bioactive materials that are able to promote cellular adhesion and proliferation. The composite biopolymeric spheres resulted in inhibited microbial growth and biofilm formation, as assessed against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans microbial strains. Significantly improved antimicrobial effects were reported in the case of chitosan-containing biomaterials, regardless of the microorganisms’ type. The nanostructured composite biopolymeric spheres evidenced proper characteristics as prolonged and controlled drug release platforms for multipurpose biomedical applications.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanomagnetite-embedded PLGA Spheres for Multipurpose Medical Applications

et al. 2019

View full text Add to dashboard Cite

show abstract

“…AMF has been previously observed to cause cell death in cells incubated with magnetic nanoparticles as stated above, and temperature rises were claimed to be responsible for such death. [7][8][9] However, either an over-recommended pair (f, H) was applied 44 or too large concentrations of magnetic nanoparticles were used 6 in many studies published so far. Other studies have described non-temperature mediated processes to explain the cell death of cells incubated with magnetic nanoparticles upon exposure to AMF.…”

Section: Cytotoxicity and Ros Evaluationmentioning

confidence: 99%

“…6 In fact, there are few studies that have reported temperature increments up to cytotoxic levels in vitro, but in all these cases, either the nanoparticle concentration used was too high and/or the pairs (f, H) used were not within the biological range. [7][8][9] However, surprisingly, some authors have observed a kind of cytotoxic effect, in which even upon the application of AMF in different cell lines incubated in vitro with magnetic nanoparticle concentrations in the order of o 500 mg mL À1 , no detectable macroscopic temperature rise was observed (or estimated). [10][11][12][13][14] No explanation for such a phenomenon is plausible at the moment.…”

Section: Introductionmentioning

confidence: 99%

Reactive oxygen species (ROS) production in HepG2 cancer cell line through the application of localized alternating magnetic field

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Despite extensive research in this area and the use of advanced therapeutic strategies (including surgical removal, radiation therapy, chemotherapy, and multiple therapy), the survival time in this disease is 12–18 months, and less than 5% of patients will survive more than 5 years . Studies have shown that in gliomagenesis, neural stem cells are transformed into GBM‐initiating cells (GICs) that imitate the behavior of stem cells.…”

Section: Introductionmentioning

confidence: 99%

The effects of melatonin on signaling pathways and molecules involved in glioma

Neamati

Asemi

2019

Fundamemntal Clinical Pharma

View full text Add to dashboard Cite

Glioblastoma is one of the most common brain tumors with high invasion and malignancy. Despite extensive research in this area and the use of new and advanced therapies, the survival rate in this disease is very low. In addition, resistance to treatment has also been observed in this disease. One of the reasons for rapid progression and failure in treatment for this disease is the presence of a class of cells with high proliferation and high differentiation, a class called glioblastoma stem‐like cells shown as being the source of glioblastoma tumors. It has been reported that several oncogenes are expressed in this disease. One important issue in recognizing the pathogenesis of this disease, and which could improve the treatment process, is the identification of involved oncogenes as well as molecules that affect the reduction of the expression of these oncogenes. Melatonin regulates the biological rhythm and inhibits the proliferation of malignant glioma cells due to antioxidant and anti‐apoptotic effects. Melatonin has been considered in biological processes and in signaling pathways involved in the development of glioma. The aim of this review is to investigate the effects of melatonin on signaling pathways and molecules involved in the progression of glioma.

show abstract

In vitro anti-cancer efficacy of multi-functionalized magnetite nanoparticles combining alternating magnetic hyperthermia in glioblastoma cancer cells

Cited by 59 publications

References 43 publications

Nanomagnetite-embedded PLGA Spheres for Multipurpose Medical Applications

Nanomagnetite-embedded PLGA Spheres for Multipurpose Medical Applications

Reactive oxygen species (ROS) production in HepG2 cancer cell line through the application of localized alternating magnetic field

The effects of melatonin on signaling pathways and molecules involved in glioma

Contact Info

Product

Resources

About